Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana

Detalhes bibliográficos
Autor(a) principal: Amato Neto, Vicente
Data de Publicação: 1990
Outros Autores: Moreira, Antonio Augusto Baillot, Ferreira, Graça Maria Pinto, Nascimento, Sérgio Antonio Barbosa do, Matsubara, Luís, Campos, Rubens, Pinto, Pedro Luiz Silva
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28730
Resumo: With the objective of knowing adequately the spectrum of activity of albendazole against intestinal helminthiases, we made observations regarding hymenolepiasis caused by Hymenolepis nana. Two series of investigations were carried out: a) treatment of mice with single doses of either 25 or 50 mg/kg, repeated after ten days, using as controls animals treated with 25 mg/kg of praziquantel or not treated with any antiparasitic drugs; b) treatment of adults and children with 400 mg daily for three consecutive days, repeated after ten days. The observations in animals have shown a lack of efficacy of albendazole, since persistence of live worms in the intestine was verified systematically. On the other hand, only 10% of the treated patients could be considered cured. Therefore, according to the procedures here described, this antiparasitic agent could not satisfactorily treat hymenolepiasis.
id IMT-1_7c94d538cdef1bf77f00fbc2b42e7f17
oai_identifier_str oai:revistas.usp.br:article/28730
network_acronym_str IMT-1
network_name_str Revista do Instituto de Medicina Tropical de São Paulo
repository_id_str
spelling Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana Avaliação da atividade terapêutica do albendazol sobre infecções experimental e humana pela Hymenolepis nana Hymenolepis nanaInfecções experimental e humanaTratamentoAlbendazol With the objective of knowing adequately the spectrum of activity of albendazole against intestinal helminthiases, we made observations regarding hymenolepiasis caused by Hymenolepis nana. Two series of investigations were carried out: a) treatment of mice with single doses of either 25 or 50 mg/kg, repeated after ten days, using as controls animals treated with 25 mg/kg of praziquantel or not treated with any antiparasitic drugs; b) treatment of adults and children with 400 mg daily for three consecutive days, repeated after ten days. The observations in animals have shown a lack of efficacy of albendazole, since persistence of live worms in the intestine was verified systematically. On the other hand, only 10% of the treated patients could be considered cured. Therefore, according to the procedures here described, this antiparasitic agent could not satisfactorily treat hymenolepiasis. Com o intuito de demarcar convenientemente o espectro de atividade do albendazol, no que diz respeito às helmintíases intestinais, foram efetuadas observações referentes à himenolepíase causada por Hymenolepis nana. Nesse contexto, duas ordens de investigações tiveram lugar: a) tratamento de camundongos, renovado depois de transcorridos dez dias, por meio de doses únicas de 25 mg/kg ou 50 mg/kg, sendo que 25 mg/kg de praziquantel e animais que não receberam os antiparasitários, serviram como controles; b) tratamento de crianças e adultos mediante uso de 400 mg cotidianamente, em três oportunidades consecutivas, com repetição após intervalo com duração de dez dias. O estudo concernente aos animais revelou ineficácia do albendazol, pois sistematicamente houve verificação da persistência de vermes vivos no intestino. Por seu turno, só 10% dos indivíduos medicados puderam ser considerados curados. Portanto, pelo menos de acordo com a maneira como procedemos, o albendazol não se afigurou capaz de debelar satisfatoriamente a himenolepíase. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1990-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28730Revista do Instituto de Medicina Tropical de São Paulo; Vol. 32 No. 3 (1990); 185-188 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 32 Núm. 3 (1990); 185-188 Revista do Instituto de Medicina Tropical de São Paulo; v. 32 n. 3 (1990); 185-188 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28730/30583Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessAmato Neto, VicenteMoreira, Antonio Augusto BaillotFerreira, Graça Maria PintoNascimento, Sérgio Antonio Barbosa doMatsubara, LuísCampos, RubensPinto, Pedro Luiz Silva2012-07-02T01:27:56Zoai:revistas.usp.br:article/28730Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:28.987061Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
Avaliação da atividade terapêutica do albendazol sobre infecções experimental e humana pela Hymenolepis nana
title Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
spellingShingle Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
Amato Neto, Vicente
Hymenolepis nana
Infecções experimental e humana
Tratamento
Albendazol
title_short Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
title_full Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
title_fullStr Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
title_full_unstemmed Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
title_sort Evaluation of therapeutic activity of albendazole against experimental and human infection by Hymenolepis nana
author Amato Neto, Vicente
author_facet Amato Neto, Vicente
Moreira, Antonio Augusto Baillot
Ferreira, Graça Maria Pinto
Nascimento, Sérgio Antonio Barbosa do
Matsubara, Luís
Campos, Rubens
Pinto, Pedro Luiz Silva
author_role author
author2 Moreira, Antonio Augusto Baillot
Ferreira, Graça Maria Pinto
Nascimento, Sérgio Antonio Barbosa do
Matsubara, Luís
Campos, Rubens
Pinto, Pedro Luiz Silva
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amato Neto, Vicente
Moreira, Antonio Augusto Baillot
Ferreira, Graça Maria Pinto
Nascimento, Sérgio Antonio Barbosa do
Matsubara, Luís
Campos, Rubens
Pinto, Pedro Luiz Silva
dc.subject.por.fl_str_mv Hymenolepis nana
Infecções experimental e humana
Tratamento
Albendazol
topic Hymenolepis nana
Infecções experimental e humana
Tratamento
Albendazol
description With the objective of knowing adequately the spectrum of activity of albendazole against intestinal helminthiases, we made observations regarding hymenolepiasis caused by Hymenolepis nana. Two series of investigations were carried out: a) treatment of mice with single doses of either 25 or 50 mg/kg, repeated after ten days, using as controls animals treated with 25 mg/kg of praziquantel or not treated with any antiparasitic drugs; b) treatment of adults and children with 400 mg daily for three consecutive days, repeated after ten days. The observations in animals have shown a lack of efficacy of albendazole, since persistence of live worms in the intestine was verified systematically. On the other hand, only 10% of the treated patients could be considered cured. Therefore, according to the procedures here described, this antiparasitic agent could not satisfactorily treat hymenolepiasis.
publishDate 1990
dc.date.none.fl_str_mv 1990-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28730
url https://www.revistas.usp.br/rimtsp/article/view/28730
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28730/30583
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 32 No. 3 (1990); 185-188
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 32 Núm. 3 (1990); 185-188
Revista do Instituto de Medicina Tropical de São Paulo; v. 32 n. 3 (1990); 185-188
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
_version_ 1798951638329720832

Registros relacionados