Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine

Detalhes bibliográficos
Autor(a) principal: Di Santi, S.M.
Data de Publicação: 1988
Outros Autores: V.L.F, Camargo Neves, Boulos, M., Dutra, A.P., Ramos, A.M.S.V., Santos, M., Barata, L.C.B.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28579
Resumo: The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests.
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spelling Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine Avaliação da resposta do Plasmodium falciparum à cloroquina, quinino e mefloquina Terapêutica da maláriaMicrotestes de sensibilidade ao Plasmodium falciparum The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests. Nosso estudo envolveu a análise de cepas de Plasmodium falciparum provenientes da Região Amazônica Brasileira, coletadas no Laboratório de Malária da SUCEN. Os estudos "in vitro" foram efetuados com a cloroquina (46 ensaios), quinino (42 ensaios) e mefloquina (51 ensaios). Os resultados mostraram resistência de 100% em relação à cloroquina, 2,4% ao quinino e 31,4% à mefloquina, na análise "in vitro". Sete pacientes foram tratados com quinino isolado e nove com a associação mefloquina + pirimetamina-sulfadoxina, não mostrando correlação com os testes "in vitro". Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1988-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28579Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 3 (1988); 147-152 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 3 (1988); 147-152 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 3 (1988); 147-152 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28579/30432Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessDi Santi, S.M.V.L.F, Camargo Neves Boulos, M.Dutra, A.P.Ramos, A.M.S.V.Santos, M.Barata, L.C.B.2012-07-02T01:04:58Zoai:revistas.usp.br:article/28579Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:18.985755Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
Avaliação da resposta do Plasmodium falciparum à cloroquina, quinino e mefloquina
title Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
spellingShingle Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
Di Santi, S.M.
Terapêutica da malária
Microtestes de sensibilidade ao Plasmodium falciparum
title_short Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
title_full Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
title_fullStr Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
title_full_unstemmed Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
title_sort Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
author Di Santi, S.M.
author_facet Di Santi, S.M.
V.L.F, Camargo Neves
Boulos, M.
Dutra, A.P.
Ramos, A.M.S.V.
Santos, M.
Barata, L.C.B.
author_role author
author2 V.L.F, Camargo Neves
Boulos, M.
Dutra, A.P.
Ramos, A.M.S.V.
Santos, M.
Barata, L.C.B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Di Santi, S.M.
V.L.F, Camargo Neves
Boulos, M.
Dutra, A.P.
Ramos, A.M.S.V.
Santos, M.
Barata, L.C.B.
dc.subject.por.fl_str_mv Terapêutica da malária
Microtestes de sensibilidade ao Plasmodium falciparum
topic Terapêutica da malária
Microtestes de sensibilidade ao Plasmodium falciparum
description The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests.
publishDate 1988
dc.date.none.fl_str_mv 1988-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28579
url https://www.revistas.usp.br/rimtsp/article/view/28579
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28579/30432
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 3 (1988); 147-152
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 3 (1988); 147-152
Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 3 (1988); 147-152
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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