HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil

Detalhes bibliográficos
Autor(a) principal: Prestes-Carneiro, Luiz Euribel
Data de Publicação: 2012
Outros Autores: Spir, Patrícia Rodrigues Naufal, Ribeiro, Armênio Alcântara, Gonçalves, Vera Lúcia Maria Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31443
Resumo: In children, vertical transmission is the main form of HIV infection. Our aim was to determine the prevalence of HIV-1 vertical transmission in mother-infant pairs in a public maternity ward in Presidente Prudente, SP. Additionally; we sought to identify characteristics associated with this form of transmission. The files of 86 HIV-1-infected mothers and their newborns referred to a Public Hospital from March 2002 to March 2007 were analyzed. The HIV-1-RNA viral load of the newborns was determined by bDNA. The HIV-1 vertical-transmission rate was 4.6%. Children that were born in the pre-term period and breastfed were at a higher risk of HIV-1 infection (p = 0.005 and p = 0.017 respectively) than children born at term and not breastfed. Prophylactic therapy with zidovudine after birth for newborns was associated with a lower risk of infection (p = 0.003). The number of newborns weighing < 2,500 g was significantly higher for infected children (p = 0.008) than for non-infected newborns. About 22.9% of mothers did not know the HIV-1 status of their newborns eight months after delivery. The study suggests that it is necessary to increase the identification of HIV-1 infection in pregnant women and their newborns as well as to offer and explain the benefits of ARV prophylaxis.
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spelling HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil Transmissão vertical do HIV e características associadas em maternidade pública em Presidente Prudente, Brasil BrazilHIV-1MTCTCharacteristics In children, vertical transmission is the main form of HIV infection. Our aim was to determine the prevalence of HIV-1 vertical transmission in mother-infant pairs in a public maternity ward in Presidente Prudente, SP. Additionally; we sought to identify characteristics associated with this form of transmission. The files of 86 HIV-1-infected mothers and their newborns referred to a Public Hospital from March 2002 to March 2007 were analyzed. The HIV-1-RNA viral load of the newborns was determined by bDNA. The HIV-1 vertical-transmission rate was 4.6%. Children that were born in the pre-term period and breastfed were at a higher risk of HIV-1 infection (p = 0.005 and p = 0.017 respectively) than children born at term and not breastfed. Prophylactic therapy with zidovudine after birth for newborns was associated with a lower risk of infection (p = 0.003). The number of newborns weighing < 2,500 g was significantly higher for infected children (p = 0.008) than for non-infected newborns. About 22.9% of mothers did not know the HIV-1 status of their newborns eight months after delivery. The study suggests that it is necessary to increase the identification of HIV-1 infection in pregnant women and their newborns as well as to offer and explain the benefits of ARV prophylaxis. A transmissão vertical é a principal forma de infecção pelo HIV em crianças. Nosso objetivo foi determinar a prevalência da transmissão vertical do HIV em maternidade pública em Presidente Prudente, SP. Além disso, procuramos identificar características associadas a essa forma de transmissão. De março de 2002 a março de 2007, os prontuários de 86 mães HIV-1 positivo e seus bebês, nascidos na maternidade de Hospital Público foram analisadas. A carga viral do HIV-1-RNA dos recém-nascidos foi determinada por bDNA. A prevalência da transmissão vertical pelo HIV-1 foi de 4,6%. Crianças nascidas a pré-termo e amamentadas tiveram um risco maior de infecção (p = 0,005 e p = 0,017, respectivamente), comparado com crianças nascidas a termo e não amamentadas. A profilaxia com zidovudina depois do nascimento para os recém-nascidos foi associada ao menor risco de infecção (p = 0,003). O número de recém-nascidos com peso < 2.500 g foi maior entre as crianças infectadas (p = 0,008), comparado com crianças não infectadas. Oito meses depois do parto 22,9% das mães não tinham conhecimento da infecção de seus bebês pelo HIV. O presente estudo sugere a necessidade em aumentar a identificação do HIV em gestantes e seus bebês e explicar e oferecer os benefícios da profilaxia antiretroviral. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31443Revista do Instituto de Medicina Tropical de São Paulo; Vol. 54 No. 1 (2012); 25-29 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 54 Núm. 1 (2012); 25-29 Revista do Instituto de Medicina Tropical de São Paulo; v. 54 n. 1 (2012); 25-29 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31443/33328Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessPrestes-Carneiro, Luiz EuribelSpir, Patrícia Rodrigues NaufalRibeiro, Armênio AlcântaraGonçalves, Vera Lúcia Maria Alves2012-07-07T19:44:36Zoai:revistas.usp.br:article/31443Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:07.034600Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
Transmissão vertical do HIV e características associadas em maternidade pública em Presidente Prudente, Brasil
title HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
spellingShingle HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
Prestes-Carneiro, Luiz Euribel
Brazil
HIV-1
MTCT
Characteristics
title_short HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
title_full HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
title_fullStr HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
title_full_unstemmed HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
title_sort HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil
author Prestes-Carneiro, Luiz Euribel
author_facet Prestes-Carneiro, Luiz Euribel
Spir, Patrícia Rodrigues Naufal
Ribeiro, Armênio Alcântara
Gonçalves, Vera Lúcia Maria Alves
author_role author
author2 Spir, Patrícia Rodrigues Naufal
Ribeiro, Armênio Alcântara
Gonçalves, Vera Lúcia Maria Alves
author2_role author
author
author
dc.contributor.author.fl_str_mv Prestes-Carneiro, Luiz Euribel
Spir, Patrícia Rodrigues Naufal
Ribeiro, Armênio Alcântara
Gonçalves, Vera Lúcia Maria Alves
dc.subject.por.fl_str_mv Brazil
HIV-1
MTCT
Characteristics
topic Brazil
HIV-1
MTCT
Characteristics
description In children, vertical transmission is the main form of HIV infection. Our aim was to determine the prevalence of HIV-1 vertical transmission in mother-infant pairs in a public maternity ward in Presidente Prudente, SP. Additionally; we sought to identify characteristics associated with this form of transmission. The files of 86 HIV-1-infected mothers and their newborns referred to a Public Hospital from March 2002 to March 2007 were analyzed. The HIV-1-RNA viral load of the newborns was determined by bDNA. The HIV-1 vertical-transmission rate was 4.6%. Children that were born in the pre-term period and breastfed were at a higher risk of HIV-1 infection (p = 0.005 and p = 0.017 respectively) than children born at term and not breastfed. Prophylactic therapy with zidovudine after birth for newborns was associated with a lower risk of infection (p = 0.003). The number of newborns weighing < 2,500 g was significantly higher for infected children (p = 0.008) than for non-infected newborns. About 22.9% of mothers did not know the HIV-1 status of their newborns eight months after delivery. The study suggests that it is necessary to increase the identification of HIV-1 infection in pregnant women and their newborns as well as to offer and explain the benefits of ARV prophylaxis.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31443
url https://www.revistas.usp.br/rimtsp/article/view/31443
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31443/33328
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 54 No. 1 (2012); 25-29
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 54 Núm. 1 (2012); 25-29
Revista do Instituto de Medicina Tropical de São Paulo; v. 54 n. 1 (2012); 25-29
1678-9946
0036-4665
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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