The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis

Detalhes bibliográficos
Autor(a) principal: Castiñeiras, Anna Carla Pinto
Data de Publicação: 2024
Outros Autores: Sales, Amanda Caroline, Picone, Camila de Melo, Diogo, Constância Lima, Rossi, Átila Duque, Galliez, Rafael Mello, Ferreira Junior, Orlando da Costa, Castiñeiras, Terezinha Marta Pereira Pinto, Lopes, Marta Heloísa, Sartori, Ana Marli Christovam
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/221562
Resumo: The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.
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spelling The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysisMeaslesSeroepidemiologic studiesAntibodiesImmunoglobulin G vaccinationMeasles-mumps-rubella vaccineHealth personnelThe global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2024-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/22156210.1590/S1678-9946202466004 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e04Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e04Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e041678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/221562/202659Copyright (c) 2024 Anna Carla Pinto Castiñeiras, Amanda Caroline Sales, Camila de Melo Picone, Constância Lima Diogo, Átila Duque Rossi, Rafael Mello Galliez, Orlando da Costa Ferreira Junior, Terezinha Marta Pereira Pinto Castiñeiras, Marta Heloísa Lopes, Ana Marli Christovam Sartorihttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCastiñeiras, Anna Carla Pinto Sales, Amanda CarolinePicone, Camila de Melo Diogo, Constância Lima Rossi, Átila DuqueGalliez, Rafael Mello Ferreira Junior, Orlando da Costa Castiñeiras, Terezinha Marta Pereira Pinto Lopes, Marta Heloísa Sartori, Ana Marli Christovam 2024-05-06T14:04:52Zoai:revistas.usp.br:article/221562Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2024-05-06T14:04:52Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
title The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
spellingShingle The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
Castiñeiras, Anna Carla Pinto
Measles
Seroepidemiologic studies
Antibodies
Immunoglobulin G vaccination
Measles-mumps-rubella vaccine
Health personnel
title_short The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
title_full The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
title_fullStr The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
title_full_unstemmed The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
title_sort The decline of measles antibody titers in previously vaccinated adults: a cross-sectional analysis
author Castiñeiras, Anna Carla Pinto
author_facet Castiñeiras, Anna Carla Pinto
Sales, Amanda Caroline
Picone, Camila de Melo
Diogo, Constância Lima
Rossi, Átila Duque
Galliez, Rafael Mello
Ferreira Junior, Orlando da Costa
Castiñeiras, Terezinha Marta Pereira Pinto
Lopes, Marta Heloísa
Sartori, Ana Marli Christovam
author_role author
author2 Sales, Amanda Caroline
Picone, Camila de Melo
Diogo, Constância Lima
Rossi, Átila Duque
Galliez, Rafael Mello
Ferreira Junior, Orlando da Costa
Castiñeiras, Terezinha Marta Pereira Pinto
Lopes, Marta Heloísa
Sartori, Ana Marli Christovam
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castiñeiras, Anna Carla Pinto
Sales, Amanda Caroline
Picone, Camila de Melo
Diogo, Constância Lima
Rossi, Átila Duque
Galliez, Rafael Mello
Ferreira Junior, Orlando da Costa
Castiñeiras, Terezinha Marta Pereira Pinto
Lopes, Marta Heloísa
Sartori, Ana Marli Christovam
dc.subject.por.fl_str_mv Measles
Seroepidemiologic studies
Antibodies
Immunoglobulin G vaccination
Measles-mumps-rubella vaccine
Health personnel
topic Measles
Seroepidemiologic studies
Antibodies
Immunoglobulin G vaccination
Measles-mumps-rubella vaccine
Health personnel
description The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/221562
10.1590/S1678-9946202466004
url https://www.revistas.usp.br/rimtsp/article/view/221562
identifier_str_mv 10.1590/S1678-9946202466004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/221562/202659
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e04
Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e04
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e04
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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