Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Blanco, Odalys
Data de Publicação: 2011
Outros Autores: Lugones, Yuliannis, Díaz, Elaine, Monzote, Lianet
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31413
Resumo: Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.
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spelling Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis Leishmania amazonensisPulmonary surfactantAntibiotic activityAntimicrobialSP-B Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®. Surfacen® es un surfactante natural exógeno extraído del pulmón, formado por fosfolípidos y proteínas hidrofóbicas, el cual es aplicado con éxito en el Síndrome de Distrés Respiratorio en Niños Recién Nacidos. En este trabajo, se describe la actividad in vitro del Surfacen® contra Leishmania amazonensis. El producto mostró actividad frente a amastigotes que se encuentran en macrófagos peritoneales de ratón BALB/c, con una CI50 de 17.9 ± 3.0 µg/mL, mientras no se observaron efectos tóxicos sobre la célula hospedera hasta 200 µg/mL. Este estudio constituye el primer reporte sobre la actividad antileishmania del Surfacen®. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31413Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 4 (2011); 235-238 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 4 (2011); 235-238 Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 4 (2011); 235-238 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31413/33298Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBlanco, OdalysLugones, YuliannisDíaz, ElaineMonzote, Lianet2012-07-07T19:41:16Zoai:revistas.usp.br:article/31413Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:05.280235Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis
title Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
spellingShingle Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
Blanco, Odalys
Leishmania amazonensis
Pulmonary surfactant
Antibiotic activity
Antimicrobial
SP-B
title_short Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
title_full Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
title_fullStr Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
title_full_unstemmed Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
title_sort Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis
author Blanco, Odalys
author_facet Blanco, Odalys
Lugones, Yuliannis
Díaz, Elaine
Monzote, Lianet
author_role author
author2 Lugones, Yuliannis
Díaz, Elaine
Monzote, Lianet
author2_role author
author
author
dc.contributor.author.fl_str_mv Blanco, Odalys
Lugones, Yuliannis
Díaz, Elaine
Monzote, Lianet
dc.subject.por.fl_str_mv Leishmania amazonensis
Pulmonary surfactant
Antibiotic activity
Antimicrobial
SP-B
topic Leishmania amazonensis
Pulmonary surfactant
Antibiotic activity
Antimicrobial
SP-B
description Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31413
url https://www.revistas.usp.br/rimtsp/article/view/31413
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31413/33298
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 4 (2011); 235-238
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 4 (2011); 235-238
Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 4 (2011); 235-238
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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