Armadillos and leprosy: from infection to biological model

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ilanna Vanessa Pristo de Medeiros
Data de Publicação: 2019
Outros Autores: Deps, Patrícia Duarte, Antunes, João Marcelo Azevedo de Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/162226
Resumo: Mycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy.
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spelling Armadillos and leprosy: from infection to biological modelMycobacterium lepraeDasypus novemcinctusEuphractus sexcinctusHansen’s diseaseLeprosyMycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2019-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/16222610.1590/s1678-9946201961044Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44Revista do Instituto de Medicina Tropical de São Paulo; v. 61 (2019); e441678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/162226/156079https://www.revistas.usp.br/rimtsp/article/view/162226/156080Oliveira, Ilanna Vanessa Pristo de MedeirosDeps, Patrícia DuarteAntunes, João Marcelo Azevedo de Paulainfo:eu-repo/semantics/openAccess2019-09-13T13:13:23Zoai:revistas.usp.br:article/162226Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:49.171882Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Armadillos and leprosy: from infection to biological model
title Armadillos and leprosy: from infection to biological model
spellingShingle Armadillos and leprosy: from infection to biological model
Oliveira, Ilanna Vanessa Pristo de Medeiros
Mycobacterium leprae
Dasypus novemcinctus
Euphractus sexcinctus
Hansen’s disease
Leprosy
title_short Armadillos and leprosy: from infection to biological model
title_full Armadillos and leprosy: from infection to biological model
title_fullStr Armadillos and leprosy: from infection to biological model
title_full_unstemmed Armadillos and leprosy: from infection to biological model
title_sort Armadillos and leprosy: from infection to biological model
author Oliveira, Ilanna Vanessa Pristo de Medeiros
author_facet Oliveira, Ilanna Vanessa Pristo de Medeiros
Deps, Patrícia Duarte
Antunes, João Marcelo Azevedo de Paula
author_role author
author2 Deps, Patrícia Duarte
Antunes, João Marcelo Azevedo de Paula
author2_role author
author
dc.contributor.author.fl_str_mv Oliveira, Ilanna Vanessa Pristo de Medeiros
Deps, Patrícia Duarte
Antunes, João Marcelo Azevedo de Paula
dc.subject.por.fl_str_mv Mycobacterium leprae
Dasypus novemcinctus
Euphractus sexcinctus
Hansen’s disease
Leprosy
topic Mycobacterium leprae
Dasypus novemcinctus
Euphractus sexcinctus
Hansen’s disease
Leprosy
description Mycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/162226
10.1590/s1678-9946201961044
url https://www.revistas.usp.br/rimtsp/article/view/162226
identifier_str_mv 10.1590/s1678-9946201961044
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/162226/156079
https://www.revistas.usp.br/rimtsp/article/view/162226/156080
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44
Revista do Instituto de Medicina Tropical de São Paulo; v. 61 (2019); e44
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
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instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
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institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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