Armadillos and leprosy: from infection to biological model
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/162226 |
Resumo: | Mycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy. |
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Armadillos and leprosy: from infection to biological modelMycobacterium lepraeDasypus novemcinctusEuphractus sexcinctusHansen’s diseaseLeprosyMycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2019-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/16222610.1590/s1678-9946201961044Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44Revista do Instituto de Medicina Tropical de São Paulo; v. 61 (2019); e441678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/162226/156079https://www.revistas.usp.br/rimtsp/article/view/162226/156080Oliveira, Ilanna Vanessa Pristo de MedeirosDeps, Patrícia DuarteAntunes, João Marcelo Azevedo de Paulainfo:eu-repo/semantics/openAccess2019-09-13T13:13:23Zoai:revistas.usp.br:article/162226Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:49.171882Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Armadillos and leprosy: from infection to biological model |
title |
Armadillos and leprosy: from infection to biological model |
spellingShingle |
Armadillos and leprosy: from infection to biological model Oliveira, Ilanna Vanessa Pristo de Medeiros Mycobacterium leprae Dasypus novemcinctus Euphractus sexcinctus Hansen’s disease Leprosy |
title_short |
Armadillos and leprosy: from infection to biological model |
title_full |
Armadillos and leprosy: from infection to biological model |
title_fullStr |
Armadillos and leprosy: from infection to biological model |
title_full_unstemmed |
Armadillos and leprosy: from infection to biological model |
title_sort |
Armadillos and leprosy: from infection to biological model |
author |
Oliveira, Ilanna Vanessa Pristo de Medeiros |
author_facet |
Oliveira, Ilanna Vanessa Pristo de Medeiros Deps, Patrícia Duarte Antunes, João Marcelo Azevedo de Paula |
author_role |
author |
author2 |
Deps, Patrícia Duarte Antunes, João Marcelo Azevedo de Paula |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Oliveira, Ilanna Vanessa Pristo de Medeiros Deps, Patrícia Duarte Antunes, João Marcelo Azevedo de Paula |
dc.subject.por.fl_str_mv |
Mycobacterium leprae Dasypus novemcinctus Euphractus sexcinctus Hansen’s disease Leprosy |
topic |
Mycobacterium leprae Dasypus novemcinctus Euphractus sexcinctus Hansen’s disease Leprosy |
description |
Mycobacterium leprae is the primary causative agent of Hansen’s disease or leprosy. Besides human beings, natural infection has been described in animals such as mangabey monkeys and armadillos. Leprosy is considered a global health problem and its complete pathogenesis is still unknown. As M. leprae does not grow in artificial media, armadillos have become the primary experimental model for leprosy, mimicking human disease including involvement of the peripheral nervous system. Leprosy transmission occurs through continuous and close contact of susceptible people with untreated infected people. However, unknown leprosy contact has been reported in leprosy-affected people, and contact with armadillos is a risk factor for leprosy. In the USA, leprosy is considered a zoonosis and this classification has recently been accepted in Brazil. This review presents information regarding the role of wild armadillos as a source of M. leprae for human infections, as well as the pathogenesis of leprosy. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/162226 10.1590/s1678-9946201961044 |
url |
https://www.revistas.usp.br/rimtsp/article/view/162226 |
identifier_str_mv |
10.1590/s1678-9946201961044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/162226/156079 https://www.revistas.usp.br/rimtsp/article/view/162226/156080 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e44 Revista do Instituto de Medicina Tropical de São Paulo; v. 61 (2019); e44 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951652270538752 |