Associantion between leprosy and hepatitis B infecion: a survey in Goiânia, Central Brazil

• Autor(a) principal: Rosa, Heitor
• Data de Publicação: 1992
• Outros Autores: Costa, Ana Paula V.F., Ferraz, Maria Lúcia, Pedroza, Suelene C., Andrade, Ana Lúcia S.S., Martelli, Celina M.T., Zicker, Fábio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28961
• topic: Leprosy and Hepatitis B virus infection; Risk factors for Hepatitis B infection; Institutionalized leprosy patients

This investigation presents the results of Hepatitis B virus screening among leprosy patients conducted in Central Brazil as a preliminary information for a HBV vaccination programme. The main objectives were to assess the seroprevalence of HBV serum markers among lepromatous patients and to analyse institutionalization as risk factor for HBV infection in this population. Two groups of lepromatous patients were studied, 83 outpatients and 171 institutionalized ones. Screening for HBV serum markers included the detection of HBsAg, anti-HBc by radioimmune assay (RIA). The prevalence of carrier state (HBsAg) was 4.8% and 8.8% among outpatients and institutionalized, respectively, (p>;0.05). Seroprevalence of exposure (all markers) was statistically significant different between outpatients (16.9%) and institutionalized ones (50.3%). Institutionalized patients had an almost four fold risk of HBV infection when compared to the outpatients, and the highest risks were among patients with more than 21 years of residence in the colony, after adjusting for age and sex.