The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis

Detalhes bibliográficos
Autor(a) principal: Tuon, Felipe Francisco
Data de Publicação: 2007
Outros Autores: Silva, Vivian Iida da, Almeida, Gisele M. Duboc de, Antonangelo, Leila, Ho, Yeh Li
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31084
Resumo: The objective of this study was to evaluate the adenosine deaminase (ADA) activity usefulness in the diagnosis of tuberculous pericarditis (TP), comparing its value with pericardial effusions (PE) caused by other pericardial diseases. A retrospective case-control study was conducted with nine cases of TP and 39 other than TP diseases (12 neoplastic, 11 septic and 16 unknown origin). Every patient included in this study had PE samples submitted to ADA activity measures and microbiological analysis, and then had pericardial tissue samples submitted to microbiological and histopathological examination. Considering the value of 40 U/L as the cut-off for the diagnosis of TP, the specificity and sensitivity were respectively of 72% and 89%. The specificity of ADA activity for the TP was best applied in the differential diagnosis from PE of unknown origin. The present study demonstrates the clinical value of the measurement of ADA activity in PE in the diagnosis of TP.
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spelling The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis O uso da adenosina deaminase no diagnóstico da tuberculose pericárdica PericarditisTuberculosisAdenosine deaminaseAcute pericarditisPericardial effusion The objective of this study was to evaluate the adenosine deaminase (ADA) activity usefulness in the diagnosis of tuberculous pericarditis (TP), comparing its value with pericardial effusions (PE) caused by other pericardial diseases. A retrospective case-control study was conducted with nine cases of TP and 39 other than TP diseases (12 neoplastic, 11 septic and 16 unknown origin). Every patient included in this study had PE samples submitted to ADA activity measures and microbiological analysis, and then had pericardial tissue samples submitted to microbiological and histopathological examination. Considering the value of 40 U/L as the cut-off for the diagnosis of TP, the specificity and sensitivity were respectively of 72% and 89%. The specificity of ADA activity for the TP was best applied in the differential diagnosis from PE of unknown origin. The present study demonstrates the clinical value of the measurement of ADA activity in PE in the diagnosis of TP. O objetivo deste estudo foi avaliar a atividade da adenosina deaminase (ADA) como auxiliar no diagnóstico da tuberculose pericárdica (TP), comparando o seu valor no derrame pericárdico com outras doenças pericárdicas. Um estudo retrospectivo tipo caso-controle foi conduzido com nove casos de TP e 39 pacientes com outras doenças pericárdicas (12 neoplasias, 11 pericardites bacterianas e 16 pericardites de etiologia indeterminada). Cada paciente incluído no estudo teve sua amostra de tecido pericárdico encaminhada para estudo microbiológico e histopatológico. Considerando o valor de 40 U/L como corte para o diagnóstico de TP, a especificidade e sensibilidade foram respectivamente 72 e 89%. A especificidade da atividade de ADA para a TP foi melhor aplicada no diagnóstico diferencial entre derrame pericárdico de origem indeterminada. O presente estudo demonstrou o valor clínico da mensuração da atividade de ADA no diagnóstico de TP. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31084Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 3 (2007); 165-170 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 3 (2007); 165-170 Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 3 (2007); 165-170 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31084/32968Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessTuon, Felipe FranciscoSilva, Vivian Iida daAlmeida, Gisele M. Duboc deAntonangelo, LeilaHo, Yeh Li2012-07-07T19:01:41Zoai:revistas.usp.br:article/31084Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:47.021385Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
O uso da adenosina deaminase no diagnóstico da tuberculose pericárdica
title The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
spellingShingle The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
Tuon, Felipe Francisco
Pericarditis
Tuberculosis
Adenosine deaminase
Acute pericarditis
Pericardial effusion
title_short The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
title_full The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
title_fullStr The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
title_full_unstemmed The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
title_sort The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis
author Tuon, Felipe Francisco
author_facet Tuon, Felipe Francisco
Silva, Vivian Iida da
Almeida, Gisele M. Duboc de
Antonangelo, Leila
Ho, Yeh Li
author_role author
author2 Silva, Vivian Iida da
Almeida, Gisele M. Duboc de
Antonangelo, Leila
Ho, Yeh Li
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tuon, Felipe Francisco
Silva, Vivian Iida da
Almeida, Gisele M. Duboc de
Antonangelo, Leila
Ho, Yeh Li
dc.subject.por.fl_str_mv Pericarditis
Tuberculosis
Adenosine deaminase
Acute pericarditis
Pericardial effusion
topic Pericarditis
Tuberculosis
Adenosine deaminase
Acute pericarditis
Pericardial effusion
description The objective of this study was to evaluate the adenosine deaminase (ADA) activity usefulness in the diagnosis of tuberculous pericarditis (TP), comparing its value with pericardial effusions (PE) caused by other pericardial diseases. A retrospective case-control study was conducted with nine cases of TP and 39 other than TP diseases (12 neoplastic, 11 septic and 16 unknown origin). Every patient included in this study had PE samples submitted to ADA activity measures and microbiological analysis, and then had pericardial tissue samples submitted to microbiological and histopathological examination. Considering the value of 40 U/L as the cut-off for the diagnosis of TP, the specificity and sensitivity were respectively of 72% and 89%. The specificity of ADA activity for the TP was best applied in the differential diagnosis from PE of unknown origin. The present study demonstrates the clinical value of the measurement of ADA activity in PE in the diagnosis of TP.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31084
url https://www.revistas.usp.br/rimtsp/article/view/31084
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31084/32968
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 3 (2007); 165-170
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 3 (2007); 165-170
Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 3 (2007); 165-170
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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