Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29288 |
Resumo: | The currently used pre-exposure anti-rabies immunization schedule in Brazil is the one called 3+1, employing suckling mouse brain vaccine (3 doses on alternate days and the last one on day 30). Although satisfactory results were obtained in well controlled experimental groups using this immunization schedule, in our routine practice, VNA levels lower than 0.5 IU/ml are frequently found. We studied the pre-exposure 3+1 schedule under field conditions in different cities on the State of São Paulo, Brazil, under variable and sometimes adverse circumstances, such as the use of different batches of vaccine with different titers, delivered, stored and administered under local conditions. Fifty out of 256 serum samples (19.5%) showed VNA titers lower than 0.5 IU/ml, but they were not distributed homogeneously among the localities studied. While in some cities the results were completely satisfactory, in others almost 40% did not attain the minimum VNA titer required. The results presented here, considered separately, question our currently used procedures for human pre-exposure anti-rabies immunization. The reasons determining this situation are discussed. |
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Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions Estudo sobre a imunização anti-rábica humana no Brazil: I - Avaliação do esquema de vacinação pré-exposição 3+1 em condições de campo RabiesPre-exposure vaccinationsuckling mouse brain anti-rabies vaccine The currently used pre-exposure anti-rabies immunization schedule in Brazil is the one called 3+1, employing suckling mouse brain vaccine (3 doses on alternate days and the last one on day 30). Although satisfactory results were obtained in well controlled experimental groups using this immunization schedule, in our routine practice, VNA levels lower than 0.5 IU/ml are frequently found. We studied the pre-exposure 3+1 schedule under field conditions in different cities on the State of São Paulo, Brazil, under variable and sometimes adverse circumstances, such as the use of different batches of vaccine with different titers, delivered, stored and administered under local conditions. Fifty out of 256 serum samples (19.5%) showed VNA titers lower than 0.5 IU/ml, but they were not distributed homogeneously among the localities studied. While in some cities the results were completely satisfactory, in others almost 40% did not attain the minimum VNA titer required. The results presented here, considered separately, question our currently used procedures for human pre-exposure anti-rabies immunization. The reasons determining this situation are discussed. O esquema de imunização anti-rábica pré-exposição mais comumente utilizado no Brasil é o chamado 3+1, com emprego de vacina produzida em tecido cerebral de camundongos recém-nascidos (3 doses em dias alternados e uma dose no dia 30). Embora tenham sido obtidos bons resultados em grupos experimentais bem controlados com este esquema de vacinação, no Laboratório de Sorologia do Instituto Pasteur, São Paulo, são encontrados, com frequência, resultados inferiores a 0,5 Ul/ml de anticorpos neutralizantes. Estudamos o esquema pré-exposição 3+1 em condições de campo, em diferentes cidades do Estado de São Paulo, em condições variáveis e talvez adversas, tais como a utilização de diferentes lotes de vacinas, com diferentes títulos, entregues, estocadas e administradas nas condições locais. Cinquenta das 256 amostras de soro (19,5%) apresentaram títulos inferiores a 0,5 UI/ml, sem que houvesse, no entanto, uma distribuição homogênea entre as cidades estudadas. Enquanto em algumas cidades os resultados foram amplamente satisfatórios, em outras quase 40% deles deixaram de atingir o nível mínimo desejável. Os resultados aqui apresentados, se considerados isoladamente, tornam questionáveis nossos procedimentos atuais de vacinação anti-rábica humana pré-exposição. As razões determinantes desta situação são discutidas no trabalho. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29288Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 349-352 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 349-352 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 349-352 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29288/31145Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessZanetti, Carlos RobertoChaves, Luciana BotelhoSilva, Andréa de Cássia RodriguesLee, Luiza MarnyPereira, Octavio Augusto de Carvalho2012-07-02T01:40:36Zoai:revistas.usp.br:article/29288Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:02.208776Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions Estudo sobre a imunização anti-rábica humana no Brazil: I - Avaliação do esquema de vacinação pré-exposição 3+1 em condições de campo |
title |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
spellingShingle |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions Zanetti, Carlos Roberto Rabies Pre-exposure vaccination suckling mouse brain anti-rabies vaccine |
title_short |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
title_full |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
title_fullStr |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
title_full_unstemmed |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
title_sort |
Studies on human anti-rabies immunization in Brazil: I - Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions |
author |
Zanetti, Carlos Roberto |
author_facet |
Zanetti, Carlos Roberto Chaves, Luciana Botelho Silva, Andréa de Cássia Rodrigues Lee, Luiza Marny Pereira, Octavio Augusto de Carvalho |
author_role |
author |
author2 |
Chaves, Luciana Botelho Silva, Andréa de Cássia Rodrigues Lee, Luiza Marny Pereira, Octavio Augusto de Carvalho |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Zanetti, Carlos Roberto Chaves, Luciana Botelho Silva, Andréa de Cássia Rodrigues Lee, Luiza Marny Pereira, Octavio Augusto de Carvalho |
dc.subject.por.fl_str_mv |
Rabies Pre-exposure vaccination suckling mouse brain anti-rabies vaccine |
topic |
Rabies Pre-exposure vaccination suckling mouse brain anti-rabies vaccine |
description |
The currently used pre-exposure anti-rabies immunization schedule in Brazil is the one called 3+1, employing suckling mouse brain vaccine (3 doses on alternate days and the last one on day 30). Although satisfactory results were obtained in well controlled experimental groups using this immunization schedule, in our routine practice, VNA levels lower than 0.5 IU/ml are frequently found. We studied the pre-exposure 3+1 schedule under field conditions in different cities on the State of São Paulo, Brazil, under variable and sometimes adverse circumstances, such as the use of different batches of vaccine with different titers, delivered, stored and administered under local conditions. Fifty out of 256 serum samples (19.5%) showed VNA titers lower than 0.5 IU/ml, but they were not distributed homogeneously among the localities studied. While in some cities the results were completely satisfactory, in others almost 40% did not attain the minimum VNA titer required. The results presented here, considered separately, question our currently used procedures for human pre-exposure anti-rabies immunization. The reasons determining this situation are discussed. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29288 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29288 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29288/31145 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 349-352 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 349-352 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 349-352 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951641632735232 |