Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/203845 |
Resumo: | Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and “leukocytoclasia”, a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation. The skin biopsy revealed histopathological changes compatible with endarteritis obliterans and LCV related to treponemal infection. This case highlights the plethora of clinical manifestations of treponemal infection and the diagnostic challenge this poses in current clinical practice. |
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Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfectionSyphilisHIVVasculitisLeukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and “leukocytoclasia”, a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation. The skin biopsy revealed histopathological changes compatible with endarteritis obliterans and LCV related to treponemal infection. This case highlights the plethora of clinical manifestations of treponemal infection and the diagnostic challenge this poses in current clinical practice.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-10-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/20384510.1590/S1678-9946202264065Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e65Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e65Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e651678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/203845/187600Copyright (c) 2022 Nicolás Ariza Ordoñez, Valeria Gómez Sepúlveda, Antonia Pino Marín, Lina Patricia Vargas Nieto, Julián Moreno León, Henry Augusto Millán Pradahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessOrdoñez, Nicolás Ariza Sepúlveda, Valeria Gómez Marín, Antonia Pino Nieto, Lina Patricia Vargas León, Julián Moreno Prada, Henry Augusto Millán 2022-10-26T19:51:29Zoai:revistas.usp.br:article/203845Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:54:10.792764Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
title |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
spellingShingle |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection Ordoñez, Nicolás Ariza Syphilis HIV Vasculitis |
title_short |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
title_full |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
title_fullStr |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
title_full_unstemmed |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
title_sort |
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection |
author |
Ordoñez, Nicolás Ariza |
author_facet |
Ordoñez, Nicolás Ariza Sepúlveda, Valeria Gómez Marín, Antonia Pino Nieto, Lina Patricia Vargas León, Julián Moreno Prada, Henry Augusto Millán |
author_role |
author |
author2 |
Sepúlveda, Valeria Gómez Marín, Antonia Pino Nieto, Lina Patricia Vargas León, Julián Moreno Prada, Henry Augusto Millán |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ordoñez, Nicolás Ariza Sepúlveda, Valeria Gómez Marín, Antonia Pino Nieto, Lina Patricia Vargas León, Julián Moreno Prada, Henry Augusto Millán |
dc.subject.por.fl_str_mv |
Syphilis HIV Vasculitis |
topic |
Syphilis HIV Vasculitis |
description |
Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and “leukocytoclasia”, a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation. The skin biopsy revealed histopathological changes compatible with endarteritis obliterans and LCV related to treponemal infection. This case highlights the plethora of clinical manifestations of treponemal infection and the diagnostic challenge this poses in current clinical practice. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/203845 10.1590/S1678-9946202264065 |
url |
https://www.revistas.usp.br/rimtsp/article/view/203845 |
identifier_str_mv |
10.1590/S1678-9946202264065 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/203845/187600 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e65 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e65 Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e65 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951659399806976 |