Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats

Detalhes bibliográficos
Autor(a) principal: Guimarães, Janaína Valadares
Data de Publicação: 2004
Outros Autores: Costa, Roberto Silva, Machado, Benedito Honório, Reis, Marlene Antônia dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30783
Resumo: The manifestations caused by Africanized bee stings depend on the sensitivity of the victim and the toxicity of the venom. Previous studies in our laboratory have demonstrated cardiac changes and acute tubular necrosis (ATN) in the kidney of rats inoculated with Africanized bee venom (ABV). The aim of the present study was to evaluate the changes in mean arterial pressure (MAP) and heart rate (HR) over a period of 24 h after intravenous injection of ABV in awake rats. A significant reduction in basal HR as well as in basal MAP occurred immediately after ABV injection in the experimental animals. HR was back to basal level 2 min after ABV injection and remained normal during the time course of the experiment, while MAP returned to basal level 10 min later and remained at this level for the next 5 h. However, MAP presented again a significant reduction by the 7th and 8th h and returned to the basal level by the 24th h. The fall in MAP may contribute to the pathogenesis of ATN observed. The fall in MAP probably is due to several factors, in addition to the cardiac changes already demonstrated, it is possible that the components of the venom themselves or even substances released in the organism play some role in vascular beds.
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spelling Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats Perfil cardiovascular após a inoculação intravenosa de veneno de abelha africanizada em ratos acordados CardiovascularMean arterial pressureHeart rateAcute renal failureAfricanized bee venom The manifestations caused by Africanized bee stings depend on the sensitivity of the victim and the toxicity of the venom. Previous studies in our laboratory have demonstrated cardiac changes and acute tubular necrosis (ATN) in the kidney of rats inoculated with Africanized bee venom (ABV). The aim of the present study was to evaluate the changes in mean arterial pressure (MAP) and heart rate (HR) over a period of 24 h after intravenous injection of ABV in awake rats. A significant reduction in basal HR as well as in basal MAP occurred immediately after ABV injection in the experimental animals. HR was back to basal level 2 min after ABV injection and remained normal during the time course of the experiment, while MAP returned to basal level 10 min later and remained at this level for the next 5 h. However, MAP presented again a significant reduction by the 7th and 8th h and returned to the basal level by the 24th h. The fall in MAP may contribute to the pathogenesis of ATN observed. The fall in MAP probably is due to several factors, in addition to the cardiac changes already demonstrated, it is possible that the components of the venom themselves or even substances released in the organism play some role in vascular beds. As manifestações causadas por picadas de abelhas africanizadas dependem da sensibilidade da vítima e da toxicidade do veneno. Estudos anteriores em nosso laboratório mostraram alterações cardíacas e necrose tubular aguda (NTA) nos rins de ratos inoculados com veneno de abelhas africanizadas (VAA). O objetivo do presente estudo foi avaliar as alterações na pressão arterial média (PAM) e na freqüência cardíaca (FC) num período de 24 horas após a inoculação de VAA em ratos mantidos acordados. Uma redução significante na FC basal e na PAM ocorreu imediatamente após a inoculação de VAA nos animais experimentais. A FC voltou aos níveis basais 2 min após a inoculação do VAA e permaneceu nestes valores durante o restante do experimento, enquanto que a PAM voltou aos níveis basais 10 min após a inoculação e permaneceu nestes níveis pelas próximas 5 horas. Por outro lado, a PAM apresentou uma nova diminuição significante nas 7ª e 8ª horas retornando aos níveis basais na 24ª hora. A queda na PAM nos animais inoculados com VAA deve contribuir na patogênese da NTA observada nos rins destes animais. Provavelmente a queda da PAM seja multifatorial, além das alterações cardíacas já demonstradas, os próprios componentes do veneno e/ou substâncias liberadas no organismo podem atuar na resistência vascular, contribuindo para alterações na pressão arterial. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2004-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30783Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 No. 1 (2004); 55-58 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 Núm. 1 (2004); 55-58 Revista do Instituto de Medicina Tropical de São Paulo; v. 46 n. 1 (2004); 55-58 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30783/32667Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessGuimarães, Janaína ValadaresCosta, Roberto SilvaMachado, Benedito HonórioReis, Marlene Antônia dos2012-07-07T18:26:52Zoai:revistas.usp.br:article/30783Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:32.209969Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
Perfil cardiovascular após a inoculação intravenosa de veneno de abelha africanizada em ratos acordados
title Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
spellingShingle Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
Guimarães, Janaína Valadares
Cardiovascular
Mean arterial pressure
Heart rate
Acute renal failure
Africanized bee venom
title_short Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
title_full Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
title_fullStr Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
title_full_unstemmed Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
title_sort Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats
author Guimarães, Janaína Valadares
author_facet Guimarães, Janaína Valadares
Costa, Roberto Silva
Machado, Benedito Honório
Reis, Marlene Antônia dos
author_role author
author2 Costa, Roberto Silva
Machado, Benedito Honório
Reis, Marlene Antônia dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Guimarães, Janaína Valadares
Costa, Roberto Silva
Machado, Benedito Honório
Reis, Marlene Antônia dos
dc.subject.por.fl_str_mv Cardiovascular
Mean arterial pressure
Heart rate
Acute renal failure
Africanized bee venom
topic Cardiovascular
Mean arterial pressure
Heart rate
Acute renal failure
Africanized bee venom
description The manifestations caused by Africanized bee stings depend on the sensitivity of the victim and the toxicity of the venom. Previous studies in our laboratory have demonstrated cardiac changes and acute tubular necrosis (ATN) in the kidney of rats inoculated with Africanized bee venom (ABV). The aim of the present study was to evaluate the changes in mean arterial pressure (MAP) and heart rate (HR) over a period of 24 h after intravenous injection of ABV in awake rats. A significant reduction in basal HR as well as in basal MAP occurred immediately after ABV injection in the experimental animals. HR was back to basal level 2 min after ABV injection and remained normal during the time course of the experiment, while MAP returned to basal level 10 min later and remained at this level for the next 5 h. However, MAP presented again a significant reduction by the 7th and 8th h and returned to the basal level by the 24th h. The fall in MAP may contribute to the pathogenesis of ATN observed. The fall in MAP probably is due to several factors, in addition to the cardiac changes already demonstrated, it is possible that the components of the venom themselves or even substances released in the organism play some role in vascular beds.
publishDate 2004
dc.date.none.fl_str_mv 2004-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30783
url https://www.revistas.usp.br/rimtsp/article/view/30783
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30783/32667
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 No. 1 (2004); 55-58
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 Núm. 1 (2004); 55-58
Revista do Instituto de Medicina Tropical de São Paulo; v. 46 n. 1 (2004); 55-58
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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