Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/190727 |
Resumo: | Chagas disease (CD) has been changing from an endemic Latino-American disease to a condition found outside endemic regions, due to migratory movements. Although often subclinical, its acute phase can be lethal. This study aimed to assess survival during the acute phase of CD and its relationship with ventricular function in an experimental model. To this end, 30 Syrian hamsters were inoculated with Trypanosoma cruzi (IG) and other 15 animals received saline solution (CG). Groups were monitored daily and submitted to echocardiography in two moments: before the challenge and 15 days post-infection. Left ventricular ejection fraction (LVEF) and global longitudinal myocardial strain (GLS) of the LV were measured. The IG was divided into groups of animals with and without clinical signs of disease. ANOVA for mixed models was used to compare ventricular function parameters. Survival analysis was studied using Kaplan-Meier curves and the log-rank test. The follow-up lasted 60 days. LVEF in IG was reduced through time (53.80 to 43.55%) compared to CG (57.86 to 59.73%) (p=0.002). There was also a reduction of GLS (−18.97% to −12.44%) in the IG compared to CG (p=0.012). Twelve animals from IG died compared to one animal from CG. Eleven out of the 12 animals from the IG group died before presenting with clinical signs of infection. Survival was reduced in the IG compared to CG over time (p=0.02). The reduced survival during the acute phase of this experimental model of Chagas disease was related to the significant reduction of LV function. The mortality rate in the IG was higher in the group presenting with clinical signs of infection. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal modelEchocardiographyAcute Chagas diseaseSpeckle-trackingAnimal experimental modelVentricular functionMyocardial deformationChagas disease (CD) has been changing from an endemic Latino-American disease to a condition found outside endemic regions, due to migratory movements. Although often subclinical, its acute phase can be lethal. This study aimed to assess survival during the acute phase of CD and its relationship with ventricular function in an experimental model. To this end, 30 Syrian hamsters were inoculated with Trypanosoma cruzi (IG) and other 15 animals received saline solution (CG). Groups were monitored daily and submitted to echocardiography in two moments: before the challenge and 15 days post-infection. Left ventricular ejection fraction (LVEF) and global longitudinal myocardial strain (GLS) of the LV were measured. The IG was divided into groups of animals with and without clinical signs of disease. ANOVA for mixed models was used to compare ventricular function parameters. Survival analysis was studied using Kaplan-Meier curves and the log-rank test. The follow-up lasted 60 days. LVEF in IG was reduced through time (53.80 to 43.55%) compared to CG (57.86 to 59.73%) (p=0.002). There was also a reduction of GLS (−18.97% to −12.44%) in the IG compared to CG (p=0.012). Twelve animals from IG died compared to one animal from CG. Eleven out of the 12 animals from the IG group died before presenting with clinical signs of infection. Survival was reduced in the IG compared to CG over time (p=0.02). The reduced survival during the acute phase of this experimental model of Chagas disease was related to the significant reduction of LV function. The mortality rate in the IG was higher in the group presenting with clinical signs of infection.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-09-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19072710.1590/S1678-9946202163061 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e61Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e61Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e611678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/190727/175896Copyright (c) 2021 Arthur Lauand Vargas, Beatriz de Paula Dias, Henrique Turin Moreira , Edgard Camilo de Oliveira Filho, Denise Mayumi Tanaka, Marcus Vinicius Simões, Benedito Carlos Maciel , André Schmidt , José Antônio Marin Neto, Minna Moreira Dias Romanohttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessVargas, Arthur Lauand Dias, Beatriz de Paula Moreira , Henrique Turin Oliveira Filho, Edgard Camilo de Tanaka, Denise Mayumi Simões, Marcus Vinicius Maciel , Benedito Carlos Schmidt , André Marin Neto, José Antônio Romano, Minna Moreira Dias 2022-05-16T13:44:35Zoai:revistas.usp.br:article/190727Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:59.392194Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
title |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
spellingShingle |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model Vargas, Arthur Lauand Echocardiography Acute Chagas disease Speckle-tracking Animal experimental model Ventricular function Myocardial deformation |
title_short |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
title_full |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
title_fullStr |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
title_full_unstemmed |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
title_sort |
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model |
author |
Vargas, Arthur Lauand |
author_facet |
Vargas, Arthur Lauand Dias, Beatriz de Paula Moreira , Henrique Turin Oliveira Filho, Edgard Camilo de Tanaka, Denise Mayumi Simões, Marcus Vinicius Maciel , Benedito Carlos Schmidt , André Marin Neto, José Antônio Romano, Minna Moreira Dias |
author_role |
author |
author2 |
Dias, Beatriz de Paula Moreira , Henrique Turin Oliveira Filho, Edgard Camilo de Tanaka, Denise Mayumi Simões, Marcus Vinicius Maciel , Benedito Carlos Schmidt , André Marin Neto, José Antônio Romano, Minna Moreira Dias |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vargas, Arthur Lauand Dias, Beatriz de Paula Moreira , Henrique Turin Oliveira Filho, Edgard Camilo de Tanaka, Denise Mayumi Simões, Marcus Vinicius Maciel , Benedito Carlos Schmidt , André Marin Neto, José Antônio Romano, Minna Moreira Dias |
dc.subject.por.fl_str_mv |
Echocardiography Acute Chagas disease Speckle-tracking Animal experimental model Ventricular function Myocardial deformation |
topic |
Echocardiography Acute Chagas disease Speckle-tracking Animal experimental model Ventricular function Myocardial deformation |
description |
Chagas disease (CD) has been changing from an endemic Latino-American disease to a condition found outside endemic regions, due to migratory movements. Although often subclinical, its acute phase can be lethal. This study aimed to assess survival during the acute phase of CD and its relationship with ventricular function in an experimental model. To this end, 30 Syrian hamsters were inoculated with Trypanosoma cruzi (IG) and other 15 animals received saline solution (CG). Groups were monitored daily and submitted to echocardiography in two moments: before the challenge and 15 days post-infection. Left ventricular ejection fraction (LVEF) and global longitudinal myocardial strain (GLS) of the LV were measured. The IG was divided into groups of animals with and without clinical signs of disease. ANOVA for mixed models was used to compare ventricular function parameters. Survival analysis was studied using Kaplan-Meier curves and the log-rank test. The follow-up lasted 60 days. LVEF in IG was reduced through time (53.80 to 43.55%) compared to CG (57.86 to 59.73%) (p=0.002). There was also a reduction of GLS (−18.97% to −12.44%) in the IG compared to CG (p=0.012). Twelve animals from IG died compared to one animal from CG. Eleven out of the 12 animals from the IG group died before presenting with clinical signs of infection. Survival was reduced in the IG compared to CG over time (p=0.02). The reduced survival during the acute phase of this experimental model of Chagas disease was related to the significant reduction of LV function. The mortality rate in the IG was higher in the group presenting with clinical signs of infection. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/190727 10.1590/S1678-9946202163061 |
url |
https://www.revistas.usp.br/rimtsp/article/view/190727 |
identifier_str_mv |
10.1590/S1678-9946202163061 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/190727/175896 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e61 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e61 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e61 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951653237325824 |