Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae

Detalhes bibliográficos
Autor(a) principal: Scuracchio, Patricia
Data de Publicação: 2011
Outros Autores: Vieira, Sergio Domingos, Dourado, Denise Albuquerque, Bueno, Luciana Moro, Colella, Rafael, Ramos-Sanchez, Eduardo Milton, Lima, Giselle F. M. Castro, Inoue, Juliana, Sanchez, Maria Carmen Arroyo, Di Santi, Silvia Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31375
Resumo: Malaria in Brazil is endemic in the Amazon region, but autochthonous cases with low parasitaemia occur in the Atlantic Forest area of the country. According to Brazilian legislation no test is mandatory for blood donors from non-endemic areas. However if they have traveled to malaria transmission regions they are deferred for six months before they can donate. This report describes a transfusion-transmitted malaria case in Sao Paulo, Brazil, where one recipient received infected blood and developed the disease. He lived in Sao Paulo and had no previous transfusion or trips to endemic areas, including those of low endemicity, such as Atlantic Forest. Thick blood smears confirmed Plasmodiummalariae. All donors lived in Sao Paulo and one of them (Donor 045-0) showed positive hemoscopy and PCR. This asymptomatic donor had traveled to Juquia, in the Atlantic Forest area of S ao Paulo State, where sporadic cases of autochthonous malaria are described. DNA assay revealed P. malariae in the donor's (Donor 045-0) blood. Serum archives of the recipient and of all blood donors were analyzed by ELISA using both P. vivax and P. falciparum antigens, and IFAT with P. malariae. Donor 045-0's serum was P. malariae IFAT positive and the P. vivax ELISA was reactive. In addition, two out of 44 donors' archive sera were also P. vivax ELISA reactive. All sera were P. falciparum ELISA negative. This case suggests the need of reviewing donor selection criteria and deferral strategies to prevent possible cases of transfusion-transmitted malaria.
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spelling Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae Malária transfusional: relato de caso de doador assintomático infectado por Plasmodium malariae Transfusion-transmitted malariaPCRMalaria serologyMalarial DNAAtlantic Forest Malaria in Brazil is endemic in the Amazon region, but autochthonous cases with low parasitaemia occur in the Atlantic Forest area of the country. According to Brazilian legislation no test is mandatory for blood donors from non-endemic areas. However if they have traveled to malaria transmission regions they are deferred for six months before they can donate. This report describes a transfusion-transmitted malaria case in Sao Paulo, Brazil, where one recipient received infected blood and developed the disease. He lived in Sao Paulo and had no previous transfusion or trips to endemic areas, including those of low endemicity, such as Atlantic Forest. Thick blood smears confirmed Plasmodiummalariae. All donors lived in Sao Paulo and one of them (Donor 045-0) showed positive hemoscopy and PCR. This asymptomatic donor had traveled to Juquia, in the Atlantic Forest area of S ao Paulo State, where sporadic cases of autochthonous malaria are described. DNA assay revealed P. malariae in the donor's (Donor 045-0) blood. Serum archives of the recipient and of all blood donors were analyzed by ELISA using both P. vivax and P. falciparum antigens, and IFAT with P. malariae. Donor 045-0's serum was P. malariae IFAT positive and the P. vivax ELISA was reactive. In addition, two out of 44 donors' archive sera were also P. vivax ELISA reactive. All sera were P. falciparum ELISA negative. This case suggests the need of reviewing donor selection criteria and deferral strategies to prevent possible cases of transfusion-transmitted malaria. No Brasil a malária é endêmica na Amazônia, porém casos autóctones com baixas parasitemias ocorrem na área costeira de Mata Atlântica. De acordo com a legislação brasileira, não são obrigatórios testes para detecção de malária em doadores de sangue de áreas não-endêmicas; entretanto são excluídos por seis meses aqueles com relato de deslocamento para áreas de transmissão. Este trabalho descreve um caso de malária transfusional ocorrido em São Paulo, Brasil, em que um paciente recebeu sangue infectado, desenvolvendo a doença. Ele residia em São Paulo e não apresentava histórico de transfusão anterior ou deslocamentos para áreas endêmicas, incluindo as de baixa endemicidade, como a Mata Atlântica. A gota espessa revelou Plasmodium malariae. Os doadores eram residentes em São Paulo e um deles (045-0) apresentou hemoscopia e PCR positivos. Este era assintomático com PCR positiva para P. malariae e viagem para Juquiá, Mata Atlântica de São Paulo, onde são descritos casos esporádicos de malária autóctone. Amostras de soro do receptor e de todos os doadores foram ensaiadas por ELISA com antígenos de P. vivax e P. falciparum e RIFI com P. malariae. O doador 045-0 apresentou RIFI positiva para P. malariae. ELISA-P. vivax foi reagente no doador infectado (045-0) e em dois dos 44 doadores. Todos os soros foram negativos com antígeno de P. falciparum. Este caso aponta a necessidade de revisão dos critérios de triagem clínico-epidemiológica para evitar casos transfusionais e também adequar as estratégias de exclusão de doadores de sangue. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31375Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 1 (2011); 55-59 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 1 (2011); 55-59 Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 1 (2011); 55-59 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31375/33260Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessScuracchio, PatriciaVieira, Sergio DomingosDourado, Denise AlbuquerqueBueno, Luciana MoroColella, RafaelRamos-Sanchez, Eduardo MiltonLima, Giselle F. M. CastroInoue, JulianaSanchez, Maria Carmen ArroyoDi Santi, Silvia Maria2012-07-07T19:38:08Zoai:revistas.usp.br:article/31375Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:02.884573Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
Malária transfusional: relato de caso de doador assintomático infectado por Plasmodium malariae
title Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
spellingShingle Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
Scuracchio, Patricia
Transfusion-transmitted malaria
PCR
Malaria serology
Malarial DNA
Atlantic Forest
title_short Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
title_full Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
title_fullStr Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
title_full_unstemmed Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
title_sort Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariae
author Scuracchio, Patricia
author_facet Scuracchio, Patricia
Vieira, Sergio Domingos
Dourado, Denise Albuquerque
Bueno, Luciana Moro
Colella, Rafael
Ramos-Sanchez, Eduardo Milton
Lima, Giselle F. M. Castro
Inoue, Juliana
Sanchez, Maria Carmen Arroyo
Di Santi, Silvia Maria
author_role author
author2 Vieira, Sergio Domingos
Dourado, Denise Albuquerque
Bueno, Luciana Moro
Colella, Rafael
Ramos-Sanchez, Eduardo Milton
Lima, Giselle F. M. Castro
Inoue, Juliana
Sanchez, Maria Carmen Arroyo
Di Santi, Silvia Maria
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Scuracchio, Patricia
Vieira, Sergio Domingos
Dourado, Denise Albuquerque
Bueno, Luciana Moro
Colella, Rafael
Ramos-Sanchez, Eduardo Milton
Lima, Giselle F. M. Castro
Inoue, Juliana
Sanchez, Maria Carmen Arroyo
Di Santi, Silvia Maria
dc.subject.por.fl_str_mv Transfusion-transmitted malaria
PCR
Malaria serology
Malarial DNA
Atlantic Forest
topic Transfusion-transmitted malaria
PCR
Malaria serology
Malarial DNA
Atlantic Forest
description Malaria in Brazil is endemic in the Amazon region, but autochthonous cases with low parasitaemia occur in the Atlantic Forest area of the country. According to Brazilian legislation no test is mandatory for blood donors from non-endemic areas. However if they have traveled to malaria transmission regions they are deferred for six months before they can donate. This report describes a transfusion-transmitted malaria case in Sao Paulo, Brazil, where one recipient received infected blood and developed the disease. He lived in Sao Paulo and had no previous transfusion or trips to endemic areas, including those of low endemicity, such as Atlantic Forest. Thick blood smears confirmed Plasmodiummalariae. All donors lived in Sao Paulo and one of them (Donor 045-0) showed positive hemoscopy and PCR. This asymptomatic donor had traveled to Juquia, in the Atlantic Forest area of S ao Paulo State, where sporadic cases of autochthonous malaria are described. DNA assay revealed P. malariae in the donor's (Donor 045-0) blood. Serum archives of the recipient and of all blood donors were analyzed by ELISA using both P. vivax and P. falciparum antigens, and IFAT with P. malariae. Donor 045-0's serum was P. malariae IFAT positive and the P. vivax ELISA was reactive. In addition, two out of 44 donors' archive sera were also P. vivax ELISA reactive. All sera were P. falciparum ELISA negative. This case suggests the need of reviewing donor selection criteria and deferral strategies to prevent possible cases of transfusion-transmitted malaria.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31375
url https://www.revistas.usp.br/rimtsp/article/view/31375
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31375/33260
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 1 (2011); 55-59
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 1 (2011); 55-59
Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 1 (2011); 55-59
1678-9946
0036-4665
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instname_str Instituto de Medicina Tropical (IMT)
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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