Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/178286 |
Resumo: | The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of mothers was 27 years (14-44), with 12.7% (41) of adolescents. The majority (66.8%) knew they were infected during pregnancy: 39.4% in the current pregnancy and 27.4% in a previous pregnancy. The incidence of MTCT was 2.7% in 2007-2009, 1% in 2010-2015 and 0 in 2016-2018. The viral load in the 3rd trimester of pregnancy was > 1.000 copies/mL or unknown in all mothers with positive newborns and in 19% (42/221) of mothers with negative newborns (p=0.003). The duration of antiretroviral use was > 4 weeks in 92.3% (264/286) of mothers with HIV-negative newborns and in 2 in the HIV-positive group (p=0.004). One of the 4 infected newborns and 2 of the negative ones did not use oral zidovudine (p=0.04). There was no association between amniorrhexis and MTCT (p=0.99), with the Apgar score in the 5th minute of life (p=0.96), with marital status (p=0.54), ethnicity (p=0.65), adolescence (p=0.42), mode of delivery (p=0.99), beginning of prenatal care (p=0.44) or with maternal comorbidities (p=0.48). The conclusion of the study points out that the main factors associated with MTCT are the elevated maternal viral load in the 3rd trimester, the time of use of ART and the non-administration of zidovudine for the newborns. |
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Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro Vertical infectious disease transmissionHIVPregnancyIncidenceThe aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of mothers was 27 years (14-44), with 12.7% (41) of adolescents. The majority (66.8%) knew they were infected during pregnancy: 39.4% in the current pregnancy and 27.4% in a previous pregnancy. The incidence of MTCT was 2.7% in 2007-2009, 1% in 2010-2015 and 0 in 2016-2018. The viral load in the 3rd trimester of pregnancy was > 1.000 copies/mL or unknown in all mothers with positive newborns and in 19% (42/221) of mothers with negative newborns (p=0.003). The duration of antiretroviral use was > 4 weeks in 92.3% (264/286) of mothers with HIV-negative newborns and in 2 in the HIV-positive group (p=0.004). One of the 4 infected newborns and 2 of the negative ones did not use oral zidovudine (p=0.04). There was no association between amniorrhexis and MTCT (p=0.99), with the Apgar score in the 5th minute of life (p=0.96), with marital status (p=0.54), ethnicity (p=0.65), adolescence (p=0.42), mode of delivery (p=0.99), beginning of prenatal care (p=0.44) or with maternal comorbidities (p=0.48). The conclusion of the study points out that the main factors associated with MTCT are the elevated maternal viral load in the 3rd trimester, the time of use of ART and the non-administration of zidovudine for the newborns.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2020-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/xmlapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/17828610.1590/s1678-9946202062066 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e66Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e66Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e661678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/178286/165188https://www.revistas.usp.br/rimtsp/article/view/178286/165187Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulohttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessGouvêa, Abilene do Nascimento Trajano, Alexandre José B. Monteiro, Denise L. M.Rodrigues, Nádia Cristina P. Costa, Julie Teixeira da Cavalcante , Mateus BenacAuar, Daniela Fortunato Gouvea, Erika Ferraz de Taquette, Stella Regina 2020-11-18T18:20:50Zoai:revistas.usp.br:article/178286Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:54.188547Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
spellingShingle |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro Gouvêa, Abilene do Nascimento Vertical infectious disease transmission HIV Pregnancy Incidence |
title_short |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_full |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_fullStr |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_full_unstemmed |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_sort |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
author |
Gouvêa, Abilene do Nascimento |
author_facet |
Gouvêa, Abilene do Nascimento Trajano, Alexandre José B. Monteiro, Denise L. M. Rodrigues, Nádia Cristina P. Costa, Julie Teixeira da Cavalcante , Mateus Benac Auar, Daniela Fortunato Gouvea, Erika Ferraz de Taquette, Stella Regina |
author_role |
author |
author2 |
Trajano, Alexandre José B. Monteiro, Denise L. M. Rodrigues, Nádia Cristina P. Costa, Julie Teixeira da Cavalcante , Mateus Benac Auar, Daniela Fortunato Gouvea, Erika Ferraz de Taquette, Stella Regina |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gouvêa, Abilene do Nascimento Trajano, Alexandre José B. Monteiro, Denise L. M. Rodrigues, Nádia Cristina P. Costa, Julie Teixeira da Cavalcante , Mateus Benac Auar, Daniela Fortunato Gouvea, Erika Ferraz de Taquette, Stella Regina |
dc.subject.por.fl_str_mv |
Vertical infectious disease transmission HIV Pregnancy Incidence |
topic |
Vertical infectious disease transmission HIV Pregnancy Incidence |
description |
The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of mothers was 27 years (14-44), with 12.7% (41) of adolescents. The majority (66.8%) knew they were infected during pregnancy: 39.4% in the current pregnancy and 27.4% in a previous pregnancy. The incidence of MTCT was 2.7% in 2007-2009, 1% in 2010-2015 and 0 in 2016-2018. The viral load in the 3rd trimester of pregnancy was > 1.000 copies/mL or unknown in all mothers with positive newborns and in 19% (42/221) of mothers with negative newborns (p=0.003). The duration of antiretroviral use was > 4 weeks in 92.3% (264/286) of mothers with HIV-negative newborns and in 2 in the HIV-positive group (p=0.004). One of the 4 infected newborns and 2 of the negative ones did not use oral zidovudine (p=0.04). There was no association between amniorrhexis and MTCT (p=0.99), with the Apgar score in the 5th minute of life (p=0.96), with marital status (p=0.54), ethnicity (p=0.65), adolescence (p=0.42), mode of delivery (p=0.99), beginning of prenatal care (p=0.44) or with maternal comorbidities (p=0.48). The conclusion of the study points out that the main factors associated with MTCT are the elevated maternal viral load in the 3rd trimester, the time of use of ART and the non-administration of zidovudine for the newborns. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/178286 10.1590/s1678-9946202062066 |
url |
https://www.revistas.usp.br/rimtsp/article/view/178286 |
identifier_str_mv |
10.1590/s1678-9946202062066 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/178286/165188 https://www.revistas.usp.br/rimtsp/article/view/178286/165187 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/xml application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e66 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e66 Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e66 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
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