Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen
Autor(a) principal: | |
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Data de Publicação: | 1988 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28617 |
Resumo: | Sixteen S. mansoni infected and untreated patients (5 with recent infection and 11 with chronic disease) were evaluated for their in vitro natural killer (NK) activity against the NK sensitive target K562 cell line. NK levels in 9 out of 11 patients (82%) with chronic disease were significantly lower (mean = 15 ± 6%),compared with patients recently infected (mean = 41 ± 9% p < 0.001) and with the control group (mean = 38 ± 13% p < 0.001). However, both patients and controls NK activity was stimulated by soluble adult worm antigens (SAWA), indicating that NK function even in the chronic stage of the infection is able to respond to the parasite antigens. These results suggest the possibility of NK cell participation as effector mechanism against S. mansoni. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen Imunopatologia da esquistossomose mansônica humana: II. Atividade NK e estimulação por antígeno específico Natural Killer cells (NK)S. mansoni Sixteen S. mansoni infected and untreated patients (5 with recent infection and 11 with chronic disease) were evaluated for their in vitro natural killer (NK) activity against the NK sensitive target K562 cell line. NK levels in 9 out of 11 patients (82%) with chronic disease were significantly lower (mean = 15 ± 6%),compared with patients recently infected (mean = 41 ± 9% p < 0.001) and with the control group (mean = 38 ± 13% p < 0.001). However, both patients and controls NK activity was stimulated by soluble adult worm antigens (SAWA), indicating that NK function even in the chronic stage of the infection is able to respond to the parasite antigens. These results suggest the possibility of NK cell participation as effector mechanism against S. mansoni. Dezesseis doentes infectados e não tratados com S. mansoni (5 com infecção recente e 11 com doença crônica), foram submetidos à avaliação de atividade de células exterminadoras na turais (NK) "in vitro" frente a células alvo de linhagem K562. Os níveis de atividade das céluIas NK em 9 de 11 doentes (827r) com a infecção crônica foram significativamente menores (média = 15 ± 6%) quando comparados aos pacientes com infecção recente (média =41 ± 9%, p < 0,001) e aos indivíduos do grupo controle (média = 38 ± 13%, p < 0,001). Porém, tanto nos doentes como nos controles, a atividade de céluIas NK foi estimulada pelo antígeno solúvel do parasito adulto (SAWA), indicando que as céluIas NK, mesmo na fase crônica da infecção, têm capacidade de responder ao antígeno dos parasitos. Estes resultados sugerem a possível participação das células NK no mecanismo efetor de defesa contra o S. mansoni. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1988-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28617Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 6 (1988); 400-405 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 6 (1988); 400-405 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 6 (1988); 400-405 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28617/30470Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessBenarroch, L. K.Noya, O.Noya, B.Bianco, N. E.Blanca, I.2012-07-02T01:07:08Zoai:revistas.usp.br:article/28617Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:21.606546Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen Imunopatologia da esquistossomose mansônica humana: II. Atividade NK e estimulação por antígeno específico |
title |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
spellingShingle |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen Benarroch, L. K. Natural Killer cells (NK) S. mansoni |
title_short |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
title_full |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
title_fullStr |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
title_full_unstemmed |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
title_sort |
Immunopathology of human schistosomiasis mansoni: II. NK activity and stimulation by specific antigen |
author |
Benarroch, L. K. |
author_facet |
Benarroch, L. K. Noya, O. Noya, B. Bianco, N. E. Blanca, I. |
author_role |
author |
author2 |
Noya, O. Noya, B. Bianco, N. E. Blanca, I. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Benarroch, L. K. Noya, O. Noya, B. Bianco, N. E. Blanca, I. |
dc.subject.por.fl_str_mv |
Natural Killer cells (NK) S. mansoni |
topic |
Natural Killer cells (NK) S. mansoni |
description |
Sixteen S. mansoni infected and untreated patients (5 with recent infection and 11 with chronic disease) were evaluated for their in vitro natural killer (NK) activity against the NK sensitive target K562 cell line. NK levels in 9 out of 11 patients (82%) with chronic disease were significantly lower (mean = 15 ± 6%),compared with patients recently infected (mean = 41 ± 9% p < 0.001) and with the control group (mean = 38 ± 13% p < 0.001). However, both patients and controls NK activity was stimulated by soluble adult worm antigens (SAWA), indicating that NK function even in the chronic stage of the infection is able to respond to the parasite antigens. These results suggest the possibility of NK cell participation as effector mechanism against S. mansoni. |
publishDate |
1988 |
dc.date.none.fl_str_mv |
1988-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28617 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28617 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28617/30470 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 No. 6 (1988); 400-405 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 30 Núm. 6 (1988); 400-405 Revista do Instituto de Medicina Tropical de São Paulo; v. 30 n. 6 (1988); 400-405 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
_version_ |
1798951637823258624 |