Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis

Detalhes bibliográficos
Autor(a) principal: Fonseca, Priscilla Duarte Marques
Data de Publicação: 2020
Outros Autores: Corral, Marcelo Andreeta, Meisel, Dirce Mary C. Lima, Levi, Debora, Nascimento, Rafael Correa, Castro‑Borges, William, Gryschek, Ronaldo, Costa-Cruz, Julia Maria, Paula, Fabiana Martins de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/169540
Resumo: In experimental infection with Strongyloides venezuelensis, the acute and recovery phases can be distinguished, unlike human infections caused by Strongyloides stercoralis. The objective of this study was to evaluate the production of anti-Strongyloides IgG antibodies and the recognition of immunogenic protein bands during the acute and the recovery phases in rats experimentally infected with S. venezuelensis. Rats were infected subcutaneously with 400 or 4,000 S. venezuelensis infective larvae. The acute phase was characterized by elimination of a large number of eggs in the faeces on days 6-14 post infection; the recovery phase was characterized by the resolution of the infection between days 30 and 35 post infection. Differences in IgG levels were observed in the acute and the recovery phases. Different antigenic fractions were recognized in both phases of infection. It is concluded that proteins within the 30-40 kDa range are immunoreactive markers for both the acute and the recovery phases in rats experimentally infected with S. venezuelensis, particularly using membrane antigen.
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spelling Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensisStrongyloides venezuelensisAcute and recovery phases30-40 kDa, IgGIn experimental infection with Strongyloides venezuelensis, the acute and recovery phases can be distinguished, unlike human infections caused by Strongyloides stercoralis. The objective of this study was to evaluate the production of anti-Strongyloides IgG antibodies and the recognition of immunogenic protein bands during the acute and the recovery phases in rats experimentally infected with S. venezuelensis. Rats were infected subcutaneously with 400 or 4,000 S. venezuelensis infective larvae. The acute phase was characterized by elimination of a large number of eggs in the faeces on days 6-14 post infection; the recovery phase was characterized by the resolution of the infection between days 30 and 35 post infection. Differences in IgG levels were observed in the acute and the recovery phases. Different antigenic fractions were recognized in both phases of infection. It is concluded that proteins within the 30-40 kDa range are immunoreactive markers for both the acute and the recovery phases in rats experimentally infected with S. venezuelensis, particularly using membrane antigen.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2020-05-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/16954010.1590/S1678-9946202062023Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e23Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e23Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e231678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/169540/160544https://www.revistas.usp.br/rimtsp/article/view/169540/160545Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessFonseca, Priscilla Duarte MarquesCorral, Marcelo AndreetaMeisel, Dirce Mary C. LimaLevi, DeboraNascimento, Rafael CorreaCastro‑Borges, WilliamGryschek, RonaldoCosta-Cruz, Julia MariaPaula, Fabiana Martins de2020-10-26T17:39:25Zoai:revistas.usp.br:article/169540Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:52.123984Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
title Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
spellingShingle Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
Fonseca, Priscilla Duarte Marques
Strongyloides venezuelensis
Acute and recovery phases
30-40 kDa, IgG
title_short Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
title_full Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
title_fullStr Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
title_full_unstemmed Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
title_sort Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis
author Fonseca, Priscilla Duarte Marques
author_facet Fonseca, Priscilla Duarte Marques
Corral, Marcelo Andreeta
Meisel, Dirce Mary C. Lima
Levi, Debora
Nascimento, Rafael Correa
Castro‑Borges, William
Gryschek, Ronaldo
Costa-Cruz, Julia Maria
Paula, Fabiana Martins de
author_role author
author2 Corral, Marcelo Andreeta
Meisel, Dirce Mary C. Lima
Levi, Debora
Nascimento, Rafael Correa
Castro‑Borges, William
Gryschek, Ronaldo
Costa-Cruz, Julia Maria
Paula, Fabiana Martins de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Priscilla Duarte Marques
Corral, Marcelo Andreeta
Meisel, Dirce Mary C. Lima
Levi, Debora
Nascimento, Rafael Correa
Castro‑Borges, William
Gryschek, Ronaldo
Costa-Cruz, Julia Maria
Paula, Fabiana Martins de
dc.subject.por.fl_str_mv Strongyloides venezuelensis
Acute and recovery phases
30-40 kDa, IgG
topic Strongyloides venezuelensis
Acute and recovery phases
30-40 kDa, IgG
description In experimental infection with Strongyloides venezuelensis, the acute and recovery phases can be distinguished, unlike human infections caused by Strongyloides stercoralis. The objective of this study was to evaluate the production of anti-Strongyloides IgG antibodies and the recognition of immunogenic protein bands during the acute and the recovery phases in rats experimentally infected with S. venezuelensis. Rats were infected subcutaneously with 400 or 4,000 S. venezuelensis infective larvae. The acute phase was characterized by elimination of a large number of eggs in the faeces on days 6-14 post infection; the recovery phase was characterized by the resolution of the infection between days 30 and 35 post infection. Differences in IgG levels were observed in the acute and the recovery phases. Different antigenic fractions were recognized in both phases of infection. It is concluded that proteins within the 30-40 kDa range are immunoreactive markers for both the acute and the recovery phases in rats experimentally infected with S. venezuelensis, particularly using membrane antigen.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/169540
10.1590/S1678-9946202062023
url https://www.revistas.usp.br/rimtsp/article/view/169540
identifier_str_mv 10.1590/S1678-9946202062023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/169540/160544
https://www.revistas.usp.br/rimtsp/article/view/169540/160545
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e23
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e23
Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e23
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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