High prevalence of malaria infection in Amazonas state, Venezuela

Detalhes bibliográficos
Autor(a) principal: Rodulfo, Hectorina
Data de Publicação: 2007
Outros Autores: Donato, Marcos de, Quijada, Isaurea, Peña, Ada
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31065
Resumo: This study was carried out to determine the incidence of malaria in an endemic region of Amazonas State, Venezuela. For this, 200 random samples were collected from symptomatic and asymptomatic individuals from San Fernando de Atabapo and Santa Barbara. Epidemiological factors were related to malaria infection, which was diagnosed by microscopy observation and amplification of the 18S rDNA sequence by PCR. Malaria prevalence in these populations was 28.5%, whilst P. vivax and P. falciparum prevalences were 12 and 17%, respectively. No infection by P. malariae was found. A mixed infection was found on an asymptomatic individual. Prevalence patterns differed between age groups depending on the Plasmodium species. We found that 34.8% of the P. vivax and 15.2% of the P. falciparum infections were asymptomatic. The use of nets was helpful to prevent P. vivax infection, but did not protect against P. falciparum infection. The results suggest the presence of more than one mosquito vector in the area, displaying a differential pattern of infection for each Plasmodium species. There appear to be risk factors associated with malaria infections in some individuals. The population based approach and PCR diagnosis improved the accuracy of the statistical analysis in the study.
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spelling High prevalence of malaria infection in Amazonas state, Venezuela Incidencia de malaria en una región endémica del estado Amazonas, Venezuela EpidemiologyMalariaPCRP. falciparumP. vivax This study was carried out to determine the incidence of malaria in an endemic region of Amazonas State, Venezuela. For this, 200 random samples were collected from symptomatic and asymptomatic individuals from San Fernando de Atabapo and Santa Barbara. Epidemiological factors were related to malaria infection, which was diagnosed by microscopy observation and amplification of the 18S rDNA sequence by PCR. Malaria prevalence in these populations was 28.5%, whilst P. vivax and P. falciparum prevalences were 12 and 17%, respectively. No infection by P. malariae was found. A mixed infection was found on an asymptomatic individual. Prevalence patterns differed between age groups depending on the Plasmodium species. We found that 34.8% of the P. vivax and 15.2% of the P. falciparum infections were asymptomatic. The use of nets was helpful to prevent P. vivax infection, but did not protect against P. falciparum infection. The results suggest the presence of more than one mosquito vector in the area, displaying a differential pattern of infection for each Plasmodium species. There appear to be risk factors associated with malaria infections in some individuals. The population based approach and PCR diagnosis improved the accuracy of the statistical analysis in the study. Este estudio fue llevado a cabo para determinar la incidencia de malaria en una región endémica del estado Amazonas, Venezuela. Doscientas muestras tomadas al azar fueron colectadas de individuos sintomáticos y asintomáticos de San Fernando de Atabapo y Santa Bárbara. Factores epidemiológicos fueron relacionados con la infección de malaria, diagnosticada por observación microscópica y por la amplificación por PCR de la secuencia del ADNr 18S. La prevalencia de malaria en estas poblaciones fue 28.5%, en tanto que las prevalencias para P. vivax y P. falciparum fueron 12 y 17%, respectivamente. No se encontró infección por P. malariae. Se encontró una infección mixta en un individuo asintomático. Los patrones de prevalencia difirieron entre los grupos de edades, dependiendo de la especie de Plasmodium. Se encontró una frecuencia de infecciones asintomáticas de 34.8% y 15.2% para P. vivax y P. falciparum, respectivamente. El uso de mosquiteros fue útil para prevenir infecciones por P. vivax, pero no protegió de infecciones por P. falciparum. Los resultados sugieren la presencia de mas de un mosquito vector en el área, mostrando patrones diferenciales de infección para cada especie de Plasmodium. Pareciera existir factores de riesgo asociados con la infección de malaria en algunos individuos. El estudio a nivel poblacional y el diagnóstico por PCR mejoró la exactitud del análisis estadístico en este estudio. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31065Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 2 (2007); 79-85 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 2 (2007); 79-85 Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 2 (2007); 79-85 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31065/32949Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRodulfo, HectorinaDonato, Marcos deQuijada, IsaureaPeña, Ada2012-07-07T18:59:44Zoai:revistas.usp.br:article/31065Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:46.008230Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv High prevalence of malaria infection in Amazonas state, Venezuela
Incidencia de malaria en una región endémica del estado Amazonas, Venezuela
title High prevalence of malaria infection in Amazonas state, Venezuela
spellingShingle High prevalence of malaria infection in Amazonas state, Venezuela
Rodulfo, Hectorina
Epidemiology
Malaria
PCR
P. falciparum
P. vivax
title_short High prevalence of malaria infection in Amazonas state, Venezuela
title_full High prevalence of malaria infection in Amazonas state, Venezuela
title_fullStr High prevalence of malaria infection in Amazonas state, Venezuela
title_full_unstemmed High prevalence of malaria infection in Amazonas state, Venezuela
title_sort High prevalence of malaria infection in Amazonas state, Venezuela
author Rodulfo, Hectorina
author_facet Rodulfo, Hectorina
Donato, Marcos de
Quijada, Isaurea
Peña, Ada
author_role author
author2 Donato, Marcos de
Quijada, Isaurea
Peña, Ada
author2_role author
author
author
dc.contributor.author.fl_str_mv Rodulfo, Hectorina
Donato, Marcos de
Quijada, Isaurea
Peña, Ada
dc.subject.por.fl_str_mv Epidemiology
Malaria
PCR
P. falciparum
P. vivax
topic Epidemiology
Malaria
PCR
P. falciparum
P. vivax
description This study was carried out to determine the incidence of malaria in an endemic region of Amazonas State, Venezuela. For this, 200 random samples were collected from symptomatic and asymptomatic individuals from San Fernando de Atabapo and Santa Barbara. Epidemiological factors were related to malaria infection, which was diagnosed by microscopy observation and amplification of the 18S rDNA sequence by PCR. Malaria prevalence in these populations was 28.5%, whilst P. vivax and P. falciparum prevalences were 12 and 17%, respectively. No infection by P. malariae was found. A mixed infection was found on an asymptomatic individual. Prevalence patterns differed between age groups depending on the Plasmodium species. We found that 34.8% of the P. vivax and 15.2% of the P. falciparum infections were asymptomatic. The use of nets was helpful to prevent P. vivax infection, but did not protect against P. falciparum infection. The results suggest the presence of more than one mosquito vector in the area, displaying a differential pattern of infection for each Plasmodium species. There appear to be risk factors associated with malaria infections in some individuals. The population based approach and PCR diagnosis improved the accuracy of the statistical analysis in the study.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31065
url https://www.revistas.usp.br/rimtsp/article/view/31065
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31065/32949
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 No. 2 (2007); 79-85
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 49 Núm. 2 (2007); 79-85
Revista do Instituto de Medicina Tropical de São Paulo; v. 49 n. 2 (2007); 79-85
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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