Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/186118 |
Resumo: | HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis. |
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Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unitHIVAIDSIntensive Care UnitDeathDialysisRenal failureHIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-04-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/18611810.1590/S1678-9946202163033Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e33Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e33Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e331678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/186118/171827Copyright (c) 2021 Malena Gadelha Cavalcante, Matheus de Sá Roriz Parente, Pedro Eduardo Andrade de Carvalho Gomes, Gdayllon Cavalcante Meneses, Geraldo Bezerra da Silva Júnior, Roberto da Justa Pires Neto, Elizabeth De Francesco Daherhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCavalcante, Malena Gadelha Parente, Matheus de Sá RorizGomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante Silva Júnior, Geraldo Bezerra da Pires Neto, Roberto da Justa Daher, Elizabeth De Francesco 2022-05-16T13:44:35Zoai:revistas.usp.br:article/186118Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:57.818207Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
spellingShingle |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit Cavalcante, Malena Gadelha HIV AIDS Intensive Care Unit Death Dialysis Renal failure |
title_short |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title_full |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title_fullStr |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title_full_unstemmed |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
title_sort |
Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit |
author |
Cavalcante, Malena Gadelha |
author_facet |
Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante Silva Júnior, Geraldo Bezerra da Pires Neto, Roberto da Justa Daher, Elizabeth De Francesco |
author_role |
author |
author2 |
Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante Silva Júnior, Geraldo Bezerra da Pires Neto, Roberto da Justa Daher, Elizabeth De Francesco |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cavalcante, Malena Gadelha Parente, Matheus de Sá Roriz Gomes, Pedro Eduardo Andrade de Carvalho Meneses, Gdayllon Cavalcante Silva Júnior, Geraldo Bezerra da Pires Neto, Roberto da Justa Daher, Elizabeth De Francesco |
dc.subject.por.fl_str_mv |
HIV AIDS Intensive Care Unit Death Dialysis Renal failure |
topic |
HIV AIDS Intensive Care Unit Death Dialysis Renal failure |
description |
HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/186118 10.1590/S1678-9946202163033 |
url |
https://www.revistas.usp.br/rimtsp/article/view/186118 |
identifier_str_mv |
10.1590/S1678-9946202163033 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/186118/171827 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e33 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e33 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e33 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
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Instituto de Medicina Tropical (IMT) |
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IMT |
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IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
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1798951653175459840 |