Azithromycin in the treatment of mucosal leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Silva-Vergara, Mario León
Data de Publicação: 2004
Outros Autores: Silva, Luciana de Almeida, Maneira, Frederico Ricardo Zago, Silva, Achilles Gustavo da, Prata, Aluízio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30814
Resumo: This report describes three elderly patients with mucosal form of American tegumentary leishmaniasis associated with chronic cardiopathy. Due to the known toxicity of classical drugs with activity against Leishmania sp., the patients received three oral courses of azithromycin therapy in single 500 mg daily dose during ten days, every other month. All lesions healed after the third series. One of the patients relapsed and a new series of azithromycin was prescribed. Azithromycin may be an alternative drug for the treatment of leishmaniasis in special situations due to its optimal mucosal and intraphagocyte concentration, single daily posology, high tolerance and oral administration. The mechanism of this drug on Leishmania sp. is unknown at present.
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spelling Azithromycin in the treatment of mucosal leishmaniasis Azitromicina no tratamento da leishmaniose mucosa Mucosal leishmaniasisAzithromycinChronic cardiopathy This report describes three elderly patients with mucosal form of American tegumentary leishmaniasis associated with chronic cardiopathy. Due to the known toxicity of classical drugs with activity against Leishmania sp., the patients received three oral courses of azithromycin therapy in single 500 mg daily dose during ten days, every other month. All lesions healed after the third series. One of the patients relapsed and a new series of azithromycin was prescribed. Azithromycin may be an alternative drug for the treatment of leishmaniasis in special situations due to its optimal mucosal and intraphagocyte concentration, single daily posology, high tolerance and oral administration. The mechanism of this drug on Leishmania sp. is unknown at present. O presente relato descreve três pacientes idosos com leishmaniose mucosa de longa evolução, os quais eram portadores de cardiopatia crônica. Pela alta freqüência de efeitos secundários e tóxicos dos medicamentos utilizados no tratamento clássico, esses pacientes receberam azitromicina. Este medicamento foi administrado pela via oral, em dose única diária de 500 mg, durante dez dias, em três séries com intervalo de um mês. Em todos, houve cicatrização das lesões depois da terceira série. Um dos pacientes apresentou recidiva após seis meses e uma nova série de azitromicina fez regredir novamente o quadro. Azitromicina pode ser uma alternativa para o tratamento das leishmanioses, principalmente pela concentração adequada em mucosas e nos fagócitos, posologia única diária, boa tolerância e administração oral. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30814Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 No. 3 (2004); 175-177 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 Núm. 3 (2004); 175-177 Revista do Instituto de Medicina Tropical de São Paulo; v. 46 n. 3 (2004); 175-177 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30814/32698Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessSilva-Vergara, Mario LeónSilva, Luciana de AlmeidaManeira, Frederico Ricardo ZagoSilva, Achilles Gustavo daPrata, Aluízio2012-07-07T18:28:40Zoai:revistas.usp.br:article/30814Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:33.768911Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Azithromycin in the treatment of mucosal leishmaniasis
Azitromicina no tratamento da leishmaniose mucosa
title Azithromycin in the treatment of mucosal leishmaniasis
spellingShingle Azithromycin in the treatment of mucosal leishmaniasis
Silva-Vergara, Mario León
Mucosal leishmaniasis
Azithromycin
Chronic cardiopathy
title_short Azithromycin in the treatment of mucosal leishmaniasis
title_full Azithromycin in the treatment of mucosal leishmaniasis
title_fullStr Azithromycin in the treatment of mucosal leishmaniasis
title_full_unstemmed Azithromycin in the treatment of mucosal leishmaniasis
title_sort Azithromycin in the treatment of mucosal leishmaniasis
author Silva-Vergara, Mario León
author_facet Silva-Vergara, Mario León
Silva, Luciana de Almeida
Maneira, Frederico Ricardo Zago
Silva, Achilles Gustavo da
Prata, Aluízio
author_role author
author2 Silva, Luciana de Almeida
Maneira, Frederico Ricardo Zago
Silva, Achilles Gustavo da
Prata, Aluízio
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva-Vergara, Mario León
Silva, Luciana de Almeida
Maneira, Frederico Ricardo Zago
Silva, Achilles Gustavo da
Prata, Aluízio
dc.subject.por.fl_str_mv Mucosal leishmaniasis
Azithromycin
Chronic cardiopathy
topic Mucosal leishmaniasis
Azithromycin
Chronic cardiopathy
description This report describes three elderly patients with mucosal form of American tegumentary leishmaniasis associated with chronic cardiopathy. Due to the known toxicity of classical drugs with activity against Leishmania sp., the patients received three oral courses of azithromycin therapy in single 500 mg daily dose during ten days, every other month. All lesions healed after the third series. One of the patients relapsed and a new series of azithromycin was prescribed. Azithromycin may be an alternative drug for the treatment of leishmaniasis in special situations due to its optimal mucosal and intraphagocyte concentration, single daily posology, high tolerance and oral administration. The mechanism of this drug on Leishmania sp. is unknown at present.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30814
url https://www.revistas.usp.br/rimtsp/article/view/30814
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30814/32698
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 No. 3 (2004); 175-177
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 46 Núm. 3 (2004); 175-177
Revista do Instituto de Medicina Tropical de São Paulo; v. 46 n. 3 (2004); 175-177
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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