Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/31427 |
Resumo: | Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV. |
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Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 Neoplasias benignas e malignas em 261 necropsias de pacientes HIV positivos no período de 1989 a 2008 HIVAIDSNeoplasm benignNeoplasm malignantNecropsy Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV. Tendo em vista que trabalhos sobre necropsias de AIDS analisam apenas neoplasias malignas e que ocorreram alterações após a terapia antiretroviral altamente eficaz (HAART), este estudo foi feito com objetivo de avaliar a frequência de neoplasias benignas e malignas nos períodos pré e pós-HAART. Estudo retrospectivo de 261 necropsias de HIV positivos entre 1989 e 2008 em Uberaba - Brasil. Foram encontradas 66 neoplasias (39 benignas, 21 malignas e seis lesões pré-invasivas) em 58 pacientes. As neoplasias malignas mais frequentes foram linfóides, em 2,7% (quatro linfomas não Hodgkin, um Hodgkin, um mieloma múltiplo e um plasmocitoma plasmoblástico) e, sarcoma de Kaposi, em 2,3% (seis casos). As benignas mais frequentes foram hemangiomas hepáticos em 11 (4,2%) dos 261 casos e leiomiomas uterinos em 11 (15,7%) das 70 mulheres. No período pré-HAART ocorreram oito (9,8%) neoplasias benignas e quatro (4,9%) malignas em 82 pacientes; no pós-HAART, 29 (16,2%) benignas e 17 (9,5%) malignas; entretanto, essas diferenças não foram estatisticamente significantes. Concluímos que a introdução da HAART em nossa região não parece ainda ter alterado a frequência de neoplasias em pacientes HIV. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31427Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 6 (2011); 309-314 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 6 (2011); 309-314 Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 6 (2011); 309-314 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31427/33312Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMicheletti, Adilha RuaMacedo, Ana Carolina SandovalSilva, Gisele Barbosa eSilva, Ana Cristina Araújo Lemos daSilva-Vergara, Mário LeonMurta, Eddie Fernando CândidoAdad, Sheila Jorge2012-07-07T19:42:22Zoai:revistas.usp.br:article/31427Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:06.172096Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 Neoplasias benignas e malignas em 261 necropsias de pacientes HIV positivos no período de 1989 a 2008 |
title |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
spellingShingle |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 Micheletti, Adilha Rua HIV AIDS Neoplasm benign Neoplasm malignant Necropsy |
title_short |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_full |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_fullStr |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_full_unstemmed |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
title_sort |
Benign and malignant neoplasias in 261 necropsies for HIV-positive patients in the period of 1989 to 2008 |
author |
Micheletti, Adilha Rua |
author_facet |
Micheletti, Adilha Rua Macedo, Ana Carolina Sandoval Silva, Gisele Barbosa e Silva, Ana Cristina Araújo Lemos da Silva-Vergara, Mário Leon Murta, Eddie Fernando Cândido Adad, Sheila Jorge |
author_role |
author |
author2 |
Macedo, Ana Carolina Sandoval Silva, Gisele Barbosa e Silva, Ana Cristina Araújo Lemos da Silva-Vergara, Mário Leon Murta, Eddie Fernando Cândido Adad, Sheila Jorge |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Micheletti, Adilha Rua Macedo, Ana Carolina Sandoval Silva, Gisele Barbosa e Silva, Ana Cristina Araújo Lemos da Silva-Vergara, Mário Leon Murta, Eddie Fernando Cândido Adad, Sheila Jorge |
dc.subject.por.fl_str_mv |
HIV AIDS Neoplasm benign Neoplasm malignant Necropsy |
topic |
HIV AIDS Neoplasm benign Neoplasm malignant Necropsy |
description |
Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/31427 |
url |
https://www.revistas.usp.br/rimtsp/article/view/31427 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/31427/33312 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 6 (2011); 309-314 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 6 (2011); 309-314 Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 6 (2011); 309-314 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951648032194560 |