Antiretroviral activity of protease inhibitors against Toxoplasma gondii

Detalhes bibliográficos
Autor(a) principal: Monzote, Lianet
Data de Publicação: 2013
Outros Autores: Rodríguez, Marta, Alfonso, Yenisey, Cox, Raymundo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/53541
Resumo: The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.
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spelling Antiretroviral activity of protease inhibitors against Toxoplasma gondii Terapia antiretroviral de inibidores da protease contra Toxoplasma gondii Toxoplasma gondiiAntiretroviral protease inhibitorsToxoplasmic encephalitis The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE. La introducción de la terapia antirretroviral de alta efectividad ha causada una marcada reducción en la ocurrencia y curso clínico de las infecciones parasitarias, incluyendo la toxoplasmosis encefálica (TE). Estos cambios han sido atribuidos a la restauración celular. Este estudio fue desarrollado para examinar la actividad de seis inhibidores de proteasas antirretrovirales (IPA) sobre taquizoitos de Toxoplasma gondii. Los seis IPA mostraron actividad anti-Toxoplasma, con valores de CI50 entre 1.4 y 6.6 µg/mL. Futuros estudios a nivel molecular deben ser realizados, los cuales podrán delucidar si el uso de IPA pudiera beneficiar o no a los pacientes que sufren de TE. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2013-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/53541Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 1 (2013); 65-67Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 1 (2013); 65-67Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 1 (2013); 65-671678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/53541/57517Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMonzote, LianetRodríguez, MartaAlfonso, YeniseyCox, Raymundo2013-04-15T13:58:14Zoai:revistas.usp.br:article/53541Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:11.951614Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Antiretroviral activity of protease inhibitors against Toxoplasma gondii
Terapia antiretroviral de inibidores da protease contra Toxoplasma gondii
title Antiretroviral activity of protease inhibitors against Toxoplasma gondii
spellingShingle Antiretroviral activity of protease inhibitors against Toxoplasma gondii
Monzote, Lianet
Toxoplasma gondii
Antiretroviral protease inhibitors
Toxoplasmic encephalitis
title_short Antiretroviral activity of protease inhibitors against Toxoplasma gondii
title_full Antiretroviral activity of protease inhibitors against Toxoplasma gondii
title_fullStr Antiretroviral activity of protease inhibitors against Toxoplasma gondii
title_full_unstemmed Antiretroviral activity of protease inhibitors against Toxoplasma gondii
title_sort Antiretroviral activity of protease inhibitors against Toxoplasma gondii
author Monzote, Lianet
author_facet Monzote, Lianet
Rodríguez, Marta
Alfonso, Yenisey
Cox, Raymundo
author_role author
author2 Rodríguez, Marta
Alfonso, Yenisey
Cox, Raymundo
author2_role author
author
author
dc.contributor.author.fl_str_mv Monzote, Lianet
Rodríguez, Marta
Alfonso, Yenisey
Cox, Raymundo
dc.subject.por.fl_str_mv Toxoplasma gondii
Antiretroviral protease inhibitors
Toxoplasmic encephalitis
topic Toxoplasma gondii
Antiretroviral protease inhibitors
Toxoplasmic encephalitis
description The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/53541
url https://www.revistas.usp.br/rimtsp/article/view/53541
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/53541/57517
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 No. 1 (2013); 65-67
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 55 Núm. 1 (2013); 65-67
Revista do Instituto de Medicina Tropical de São Paulo; v. 55 n. 1 (2013); 65-67
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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