Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract

Detalhes bibliográficos
Autor(a) principal: Parra, Marley García
Data de Publicação: 2010
Outros Autores: Fidalgo, Lianet Monzote, Martinez, Judith Mendiola, Alvarez, Ana Margarita Montalvo, Iglesias, Olga Valdés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/31308
Resumo: In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 μg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
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spelling Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract Atividade leishmanicida do extrato de Echinaster (Othilia) echinophorus Leishmania amazonensisEchinaster (Othilia) echinophorusAntiprotozoal activitySaponins In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 μg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally. Neste estudo descreve-se o efeito de um extrato metanólico de Echinaster echinophorus spp. no parasita Leishmania amazonensis. Em testes com as formas promastigotas e amastigotas, o IC50 do extrato foi 62,9 e 37,5 μg.mL-1, respectivamente. O extrato também tem toxicidade moderada em macrófagos de camundongos BALB/c. O tratamento de camundongos BALB/c infectados com L. amazonensis com doses diárias de 100 mg/kg/dia via intraperitoneal durante 15 dias mostrou-se relativamente efetivo no controle da infecção. Esta investigação confirma a importância de produtos naturais como fonte para a descoberta de fármacos com funções anti-Leishmania. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31308Revista do Instituto de Medicina Tropical de São Paulo; Vol. 52 No. 2 (2010); 89-93 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 52 Núm. 2 (2010); 89-93 Revista do Instituto de Medicina Tropical de São Paulo; v. 52 n. 2 (2010); 89-93 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31308/33193Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessParra, Marley GarcíaFidalgo, Lianet MonzoteMartinez, Judith MendiolaAlvarez, Ana Margarita MontalvoIglesias, Olga Valdés2012-07-07T19:30:23Zoai:revistas.usp.br:article/31308Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:59.152134Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
Atividade leishmanicida do extrato de Echinaster (Othilia) echinophorus
title Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
spellingShingle Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
Parra, Marley García
Leishmania amazonensis
Echinaster (Othilia) echinophorus
Antiprotozoal activity
Saponins
title_short Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
title_full Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
title_fullStr Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
title_full_unstemmed Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
title_sort Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract
author Parra, Marley García
author_facet Parra, Marley García
Fidalgo, Lianet Monzote
Martinez, Judith Mendiola
Alvarez, Ana Margarita Montalvo
Iglesias, Olga Valdés
author_role author
author2 Fidalgo, Lianet Monzote
Martinez, Judith Mendiola
Alvarez, Ana Margarita Montalvo
Iglesias, Olga Valdés
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Parra, Marley García
Fidalgo, Lianet Monzote
Martinez, Judith Mendiola
Alvarez, Ana Margarita Montalvo
Iglesias, Olga Valdés
dc.subject.por.fl_str_mv Leishmania amazonensis
Echinaster (Othilia) echinophorus
Antiprotozoal activity
Saponins
topic Leishmania amazonensis
Echinaster (Othilia) echinophorus
Antiprotozoal activity
Saponins
description In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 μg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31308
url https://www.revistas.usp.br/rimtsp/article/view/31308
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31308/33193
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 52 No. 2 (2010); 89-93
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 52 Núm. 2 (2010); 89-93
Revista do Instituto de Medicina Tropical de São Paulo; v. 52 n. 2 (2010); 89-93
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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