Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients

Detalhes bibliográficos
Autor(a) principal: Diniz, Simone Magalhães
Data de Publicação: 2024
Outros Autores: Mauad, Vitor Augusto Queiroz, Fernandes, Caio Cesar Ferreira, Bacci, Marcelo Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/230433
Resumo: Acute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients.
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spelling Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patientsCOVID-19Acute respiratory distress syndromeD-dimerMechanical ventilationAcute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2024-10-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/23043310.1590/Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e57Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e571678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/230433/209011Copyright (c) 2024 Simone Magalhães Diniz, Vitor Augusto Queiroz Mauad, Caio Cesar Ferreira Fernandes, Marcelo Rodrigues Baccihttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessDiniz, Simone MagalhãesMauad, Vitor Augusto Queiroz Fernandes, Caio Cesar FerreiraBacci, Marcelo Rodrigues2024-10-14T18:02:12Zoai:revistas.usp.br:article/230433Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2024-10-14T18:02:12Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
title Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
spellingShingle Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
Diniz, Simone Magalhães
COVID-19
Acute respiratory distress syndrome
D-dimer
Mechanical ventilation
title_short Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
title_full Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
title_fullStr Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
title_full_unstemmed Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
title_sort Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
author Diniz, Simone Magalhães
author_facet Diniz, Simone Magalhães
Mauad, Vitor Augusto Queiroz
Fernandes, Caio Cesar Ferreira
Bacci, Marcelo Rodrigues
author_role author
author2 Mauad, Vitor Augusto Queiroz
Fernandes, Caio Cesar Ferreira
Bacci, Marcelo Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv Diniz, Simone Magalhães
Mauad, Vitor Augusto Queiroz
Fernandes, Caio Cesar Ferreira
Bacci, Marcelo Rodrigues
dc.subject.por.fl_str_mv COVID-19
Acute respiratory distress syndrome
D-dimer
Mechanical ventilation
topic COVID-19
Acute respiratory distress syndrome
D-dimer
Mechanical ventilation
description Acute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients.
publishDate 2024
dc.date.none.fl_str_mv 2024-10-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/230433
10.1590/
url https://www.revistas.usp.br/rimtsp/article/view/230433
identifier_str_mv 10.1590/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/230433/209011
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57
Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e57
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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