Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/230433 |
Resumo: | Acute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients. |
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Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patientsCOVID-19Acute respiratory distress syndromeD-dimerMechanical ventilationAcute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2024-10-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/23043310.1590/Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e57Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e571678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/230433/209011Copyright (c) 2024 Simone Magalhães Diniz, Vitor Augusto Queiroz Mauad, Caio Cesar Ferreira Fernandes, Marcelo Rodrigues Baccihttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessDiniz, Simone MagalhãesMauad, Vitor Augusto Queiroz Fernandes, Caio Cesar FerreiraBacci, Marcelo Rodrigues2024-10-14T18:02:12Zoai:revistas.usp.br:article/230433Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2024-10-14T18:02:12Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false |
dc.title.none.fl_str_mv |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
title |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
spellingShingle |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients Diniz, Simone Magalhães COVID-19 Acute respiratory distress syndrome D-dimer Mechanical ventilation |
title_short |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
title_full |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
title_fullStr |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
title_full_unstemmed |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
title_sort |
Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients |
author |
Diniz, Simone Magalhães |
author_facet |
Diniz, Simone Magalhães Mauad, Vitor Augusto Queiroz Fernandes, Caio Cesar Ferreira Bacci, Marcelo Rodrigues |
author_role |
author |
author2 |
Mauad, Vitor Augusto Queiroz Fernandes, Caio Cesar Ferreira Bacci, Marcelo Rodrigues |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Diniz, Simone Magalhães Mauad, Vitor Augusto Queiroz Fernandes, Caio Cesar Ferreira Bacci, Marcelo Rodrigues |
dc.subject.por.fl_str_mv |
COVID-19 Acute respiratory distress syndrome D-dimer Mechanical ventilation |
topic |
COVID-19 Acute respiratory distress syndrome D-dimer Mechanical ventilation |
description |
Acute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-10-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/230433 10.1590/ |
url |
https://www.revistas.usp.br/rimtsp/article/view/230433 |
identifier_str_mv |
10.1590/ |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/230433/209011 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57 Revista do Instituto de Medicina Tropical de São Paulo; v. 66 (2024); e57 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 66 (2024); e57 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1816897437561782272 |