Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Rabello, Ana Lúcia Teles
Data de Publicação: 1992
Outros Autores: Rocha, Roberto Sena, Oliveira, João Paulo Mendes de, Katz, Naftale, Lambertucci, José Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28987
Resumo: From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods.
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spelling Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni Exame de fezes e biópsia retal no diagnóstico e controle de cura da esquistossomose mansoni Schistosoma mansoniStool examinationEgg countsRectal biopsyOxamniquine From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods. Em um grupo de 217 adultos do sexo masculino selecionados através de ELISA ou intradermoreação, realizaram-se seis exames de fezes pelos métodos de Lutz/Hoffman, Pons e Janer (Lutz/HPJ) e Kato/Katz e um oograma da mucosa retal, observando-se positividade em 44,7%, 47,5% e 40,1%, respectivamente. A análise comparativa dos resultados mostrou: 1) aumento da sensibilidade de ambos os métodos de exames de fezes até a terceira amostra examinada; 2) maior sensibilidade da biópsia retal quando comparada ao exame de uma única amostra fecal pelos métodos de Lutz/HPJ ou Kato/Katz; 3) igual sensibilidade pelo exame de duas a cinco amostras fecais pelo método de Kato/Katz ou duas a seis amostras pelo método de Lutz/HPJ e a biópsia retal; 4) sensibilidade superior de seis amostras fecais pelo método de Kato/Katz, quando comparado à biópsia retal; 5) igual sensibilidade entre o mesmo número de amostras examinadas pelos métodos de Lutz/HPJ e Kato/Katz. Para avaliar a cura parasitológica, os últimos 40 pacientes do grupo A, tratados com oxamniquine oral, dose única, 15 mg/kg foram acompanhados durante seis meses (Grupo B). O controle de cura incluiu três exames de fezes mensais, pelos métodos de Lutz/HPJ e Kato/Katz no 1º, 3º e 6º meses e uma biópsia retal, entre o 4º e 6º meses após o tratamento. Os exames foram negativos em 87,5%, 90,0% e 95,0% dos pacientes tratados e avaliados pelos métodos de Kato/Katz, Luiz/HPJ e biópsia retal, respectivamente. O percentual de cura com a oxamniquine foi de 82,5%, quando considerados os três métodos de controle parasitológico associados e, não houve diferença estatística entre o número de casos considerados curados por um deles. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28987Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 6 (1992); 601-608 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28987/30844Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRabello, Ana Lúcia TelesRocha, Roberto SenaOliveira, João Paulo Mendes deKatz, NaftaleLambertucci, José Roberto2012-07-02T01:34:07Zoai:revistas.usp.br:article/28987Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:44.984605Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
Exame de fezes e biópsia retal no diagnóstico e controle de cura da esquistossomose mansoni
title Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
spellingShingle Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
Rabello, Ana Lúcia Teles
Schistosoma mansoni
Stool examination
Egg counts
Rectal biopsy
Oxamniquine
title_short Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
title_full Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
title_fullStr Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
title_full_unstemmed Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
title_sort Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
author Rabello, Ana Lúcia Teles
author_facet Rabello, Ana Lúcia Teles
Rocha, Roberto Sena
Oliveira, João Paulo Mendes de
Katz, Naftale
Lambertucci, José Roberto
author_role author
author2 Rocha, Roberto Sena
Oliveira, João Paulo Mendes de
Katz, Naftale
Lambertucci, José Roberto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rabello, Ana Lúcia Teles
Rocha, Roberto Sena
Oliveira, João Paulo Mendes de
Katz, Naftale
Lambertucci, José Roberto
dc.subject.por.fl_str_mv Schistosoma mansoni
Stool examination
Egg counts
Rectal biopsy
Oxamniquine
topic Schistosoma mansoni
Stool examination
Egg counts
Rectal biopsy
Oxamniquine
description From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods.
publishDate 1992
dc.date.none.fl_str_mv 1992-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28987
url https://www.revistas.usp.br/rimtsp/article/view/28987
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28987/30844
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 6 (1992); 601-608
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 6 (1992); 601-608
Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 6 (1992); 601-608
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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