Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28987 |
Resumo: | From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods. |
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Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni Exame de fezes e biópsia retal no diagnóstico e controle de cura da esquistossomose mansoni Schistosoma mansoniStool examinationEgg countsRectal biopsyOxamniquine From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods. Em um grupo de 217 adultos do sexo masculino selecionados através de ELISA ou intradermoreação, realizaram-se seis exames de fezes pelos métodos de Lutz/Hoffman, Pons e Janer (Lutz/HPJ) e Kato/Katz e um oograma da mucosa retal, observando-se positividade em 44,7%, 47,5% e 40,1%, respectivamente. A análise comparativa dos resultados mostrou: 1) aumento da sensibilidade de ambos os métodos de exames de fezes até a terceira amostra examinada; 2) maior sensibilidade da biópsia retal quando comparada ao exame de uma única amostra fecal pelos métodos de Lutz/HPJ ou Kato/Katz; 3) igual sensibilidade pelo exame de duas a cinco amostras fecais pelo método de Kato/Katz ou duas a seis amostras pelo método de Lutz/HPJ e a biópsia retal; 4) sensibilidade superior de seis amostras fecais pelo método de Kato/Katz, quando comparado à biópsia retal; 5) igual sensibilidade entre o mesmo número de amostras examinadas pelos métodos de Lutz/HPJ e Kato/Katz. Para avaliar a cura parasitológica, os últimos 40 pacientes do grupo A, tratados com oxamniquine oral, dose única, 15 mg/kg foram acompanhados durante seis meses (Grupo B). O controle de cura incluiu três exames de fezes mensais, pelos métodos de Lutz/HPJ e Kato/Katz no 1º, 3º e 6º meses e uma biópsia retal, entre o 4º e 6º meses após o tratamento. Os exames foram negativos em 87,5%, 90,0% e 95,0% dos pacientes tratados e avaliados pelos métodos de Kato/Katz, Luiz/HPJ e biópsia retal, respectivamente. O percentual de cura com a oxamniquine foi de 82,5%, quando considerados os três métodos de controle parasitológico associados e, não houve diferença estatística entre o número de casos considerados curados por um deles. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28987Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 6 (1992); 601-608 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28987/30844Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRabello, Ana Lúcia TelesRocha, Roberto SenaOliveira, João Paulo Mendes deKatz, NaftaleLambertucci, José Roberto2012-07-02T01:34:07Zoai:revistas.usp.br:article/28987Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:44.984605Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni Exame de fezes e biópsia retal no diagnóstico e controle de cura da esquistossomose mansoni |
title |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
spellingShingle |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni Rabello, Ana Lúcia Teles Schistosoma mansoni Stool examination Egg counts Rectal biopsy Oxamniquine |
title_short |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
title_full |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
title_fullStr |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
title_full_unstemmed |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
title_sort |
Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni |
author |
Rabello, Ana Lúcia Teles |
author_facet |
Rabello, Ana Lúcia Teles Rocha, Roberto Sena Oliveira, João Paulo Mendes de Katz, Naftale Lambertucci, José Roberto |
author_role |
author |
author2 |
Rocha, Roberto Sena Oliveira, João Paulo Mendes de Katz, Naftale Lambertucci, José Roberto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rabello, Ana Lúcia Teles Rocha, Roberto Sena Oliveira, João Paulo Mendes de Katz, Naftale Lambertucci, José Roberto |
dc.subject.por.fl_str_mv |
Schistosoma mansoni Stool examination Egg counts Rectal biopsy Oxamniquine |
topic |
Schistosoma mansoni Stool examination Egg counts Rectal biopsy Oxamniquine |
description |
From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28987 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28987 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28987/30844 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 6 (1992); 601-608 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 6 (1992); 601-608 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951639945576448 |