Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/30645 |
Resumo: | The present study was carried out to evaluate the Malar-CheckTM Pf test, an immunochromatographic assay that detects Plasmodium falciparum Histidine Rich Protein II, does not require equipment, and is easy and rapid to perform. In dilution assays performed to test sensitivity against known parasite density, Malar-CheckTMwere compared with thick blood smear (TBS), the gold standard for diagnosis. Palo Alto isolate or P. falciparum blood from patients with different parasitemias was used. The average cut-off points for each technique in three independent experiments were 12 and 71 parasites/mm³ (TBS and Malar-CheckTM, respectively). In the field assays, samples were collected from patients with fever who visited endemic regions. Compared to TBS, Malar-CheckTMyielded true-positive results in 38 patients, false-positive results in 3, true-negative results in 23, and false-negative result in 1. Malar-CheckTMperformed with samples from falciparum-infected patients after treatment showed persistence of antigen up to 30 days. Malar-CheckTM should aid the diagnosis of P. falciparum in remote areas and improve routine diagnosis even when microscopy is available. Previous P. falciparum infection, which can determine a false-positive test in cured individuals, should be considered. The prompt results obtained with the Malar-CheckTM for early diagnosis could avoid disease evolution to severe cases. |
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Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil Evaluation of a rapid dipstick test, Malar-CheckTM, for the diagnosis of Plasmodium falciparum malaria in Brazil Malaria diagnosisPlasmodium falciparumRapid dipstick testImmunocapture assayMalar-CheckHistidine Rich Protein II The present study was carried out to evaluate the Malar-CheckTM Pf test, an immunochromatographic assay that detects Plasmodium falciparum Histidine Rich Protein II, does not require equipment, and is easy and rapid to perform. In dilution assays performed to test sensitivity against known parasite density, Malar-CheckTMwere compared with thick blood smear (TBS), the gold standard for diagnosis. Palo Alto isolate or P. falciparum blood from patients with different parasitemias was used. The average cut-off points for each technique in three independent experiments were 12 and 71 parasites/mm³ (TBS and Malar-CheckTM, respectively). In the field assays, samples were collected from patients with fever who visited endemic regions. Compared to TBS, Malar-CheckTMyielded true-positive results in 38 patients, false-positive results in 3, true-negative results in 23, and false-negative result in 1. Malar-CheckTMperformed with samples from falciparum-infected patients after treatment showed persistence of antigen up to 30 days. Malar-CheckTM should aid the diagnosis of P. falciparum in remote areas and improve routine diagnosis even when microscopy is available. Previous P. falciparum infection, which can determine a false-positive test in cured individuals, should be considered. The prompt results obtained with the Malar-CheckTM for early diagnosis could avoid disease evolution to severe cases. Este trabalho avaliou o Malar-CheckTM Pf test, ensaio imunocromatográfico que detecta a proteína rica em histidina de Plasmodium falciparum, dispensa uso de equipamentos, é rápido e de fácil execução. Ensaios de diluição com o isolado Palo Alto ou sangue de pacientes com P. falciparum, foram realizados para testar a sensibilidade em diferentes densidades do parasita. Malar-CheckTM foi comparado à gota espessa (GE), padrão ouro para diagnóstico de malária. A média do limiar de sensibilidade para cada técnica em três experimentos independentes foi de 12 e 71 parasitas/mm³ (GE e Malar-CheckTM, respectivamente). Em ensaios de campo, amostras foram coletadas de pacientes febris de áreas endêmicas. Comparado à GE, Malar-CheckTM foi verdadeiramente positivo em 38 pacientes, falso positivo em 3, verdadeiramente negativo em 23 e falso negativo em um. Malar-CheckTMrealizado com sangue de pacientes com P. falciparum após tratamento mostrou persistência do antígeno durante 30 dias. Malar-CheckTM pode ser útil no diagnóstico de P. falciparum em áreas remotas e auxiliar a rotina diagnóstica, mesmo quando a microscopia está disponível. Deve ser considerada infecção pregressa por P. falciparum, que pode determinar testes positivos em indivíduos curados. A rapidez do Malar-CheckTM para o diagnóstico precoce pode evitar evolução para casos graves. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2002-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30645Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 5 (2002); 293-296 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 5 (2002); 293-296 Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 5 (2002); 293-296 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30645/32529Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessAVILA, Priscilla ElisangelaKIRCHGATTER, KarinBRUNIALTI, Karen Cristina S.OLIVEIRA, Alessandra M.SICILIANO, Rinaldo F.DI SANTI, Silvia Maria2012-07-07T17:53:17Zoai:revistas.usp.br:article/30645Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:25.158336Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil Evaluation of a rapid dipstick test, Malar-CheckTM, for the diagnosis of Plasmodium falciparum malaria in Brazil |
title |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
spellingShingle |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil AVILA, Priscilla Elisangela Malaria diagnosis Plasmodium falciparum Rapid dipstick test Immunocapture assay Malar-Check Histidine Rich Protein II |
title_short |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
title_full |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
title_fullStr |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
title_full_unstemmed |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
title_sort |
Avaliação de um teste rápido em fita, Malar-CheckTM, para o diagnóstico de malária por Plasmodium falciparum no Brasil |
author |
AVILA, Priscilla Elisangela |
author_facet |
AVILA, Priscilla Elisangela KIRCHGATTER, Karin BRUNIALTI, Karen Cristina S. OLIVEIRA, Alessandra M. SICILIANO, Rinaldo F. DI SANTI, Silvia Maria |
author_role |
author |
author2 |
KIRCHGATTER, Karin BRUNIALTI, Karen Cristina S. OLIVEIRA, Alessandra M. SICILIANO, Rinaldo F. DI SANTI, Silvia Maria |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
AVILA, Priscilla Elisangela KIRCHGATTER, Karin BRUNIALTI, Karen Cristina S. OLIVEIRA, Alessandra M. SICILIANO, Rinaldo F. DI SANTI, Silvia Maria |
dc.subject.por.fl_str_mv |
Malaria diagnosis Plasmodium falciparum Rapid dipstick test Immunocapture assay Malar-Check Histidine Rich Protein II |
topic |
Malaria diagnosis Plasmodium falciparum Rapid dipstick test Immunocapture assay Malar-Check Histidine Rich Protein II |
description |
The present study was carried out to evaluate the Malar-CheckTM Pf test, an immunochromatographic assay that detects Plasmodium falciparum Histidine Rich Protein II, does not require equipment, and is easy and rapid to perform. In dilution assays performed to test sensitivity against known parasite density, Malar-CheckTMwere compared with thick blood smear (TBS), the gold standard for diagnosis. Palo Alto isolate or P. falciparum blood from patients with different parasitemias was used. The average cut-off points for each technique in three independent experiments were 12 and 71 parasites/mm³ (TBS and Malar-CheckTM, respectively). In the field assays, samples were collected from patients with fever who visited endemic regions. Compared to TBS, Malar-CheckTMyielded true-positive results in 38 patients, false-positive results in 3, true-negative results in 23, and false-negative result in 1. Malar-CheckTMperformed with samples from falciparum-infected patients after treatment showed persistence of antigen up to 30 days. Malar-CheckTM should aid the diagnosis of P. falciparum in remote areas and improve routine diagnosis even when microscopy is available. Previous P. falciparum infection, which can determine a false-positive test in cured individuals, should be considered. The prompt results obtained with the Malar-CheckTM for early diagnosis could avoid disease evolution to severe cases. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/30645 |
url |
https://www.revistas.usp.br/rimtsp/article/view/30645 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/30645/32529 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 5 (2002); 293-296 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 5 (2002); 293-296 Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 5 (2002); 293-296 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951643869347840 |