Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients

Detalhes bibliográficos
Autor(a) principal: Costa, Cássia Cardoso
Data de Publicação: 2019
Outros Autores: Lyra, Jorge Soares, Nakamura, Ricardo Akiyoshi, Sousa, Carine Medeiros de
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/275
Resumo: Introduction: Radiotherapy is one of the therapeutic modalities chosen for adjuvant and neoadjuvant treatment in patients with breast cancer. This modality causes a painful skin reaction known as radiodermatitis. Objective: To evaluate the factors related with the appearance of radiodermatitis after radiotherapy and their relationship with the highest degree of toxicity in patients with breast cancer. Method: Retrospective study, with 117 patients with breast cancer submitted to 3D conformational radiotherapy between 2016 and 2018, at variable doses. Personal data were collected from medical records, and the degree of radiodermatitis established according to the criteria of the Radiation Oncology Group. The total of 15 predictive factors in potential were listed and later analyzed by univariate and multivariate statistics. Results: The study population presented an average of 50 years, 47% reported some comorbidities, 59.83% underwent radical surgery and 81.19% developed radiodermatitis. In a multivariate analysis, there was an association between development of radiodermatitis and higher doses of radiation (p=0.011) and daily bolus use (p=0.009). Conclusion: The main elements that culminated in higher degrees of radiodermatitis were the dose of radiation and the use of daily bolus. By categorizing the predictive factors, we can identify the patient with the highest risk of severe skin lesions and enables the creation of more effective protocols for the prevention of radiodermatitis.
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spelling Radiodermatitis: Analysis of Predictive Factors in Breast Cancer PatientsRadiodermatitis: Análisis de Factores Predictivos en Pacientes con Cáncer de MamaRadiodermatites: Análise dos Fatores Preditivos em Pacientes com Câncer de MamaRadiodermatiteNeoplasias da MamaToxicidade AgudaRadioterapiaRadiodermatitisBreast NeoplasmsAcute ToxicityRadiotherapyRadiodermatitisNeoplasias de la MamaToxicidad AgudaRadioterapiaIntroduction: Radiotherapy is one of the therapeutic modalities chosen for adjuvant and neoadjuvant treatment in patients with breast cancer. This modality causes a painful skin reaction known as radiodermatitis. Objective: To evaluate the factors related with the appearance of radiodermatitis after radiotherapy and their relationship with the highest degree of toxicity in patients with breast cancer. Method: Retrospective study, with 117 patients with breast cancer submitted to 3D conformational radiotherapy between 2016 and 2018, at variable doses. Personal data were collected from medical records, and the degree of radiodermatitis established according to the criteria of the Radiation Oncology Group. The total of 15 predictive factors in potential were listed and later analyzed by univariate and multivariate statistics. Results: The study population presented an average of 50 years, 47% reported some comorbidities, 59.83% underwent radical surgery and 81.19% developed radiodermatitis. In a multivariate analysis, there was an association between development of radiodermatitis and higher doses of radiation (p=0.011) and daily bolus use (p=0.009). Conclusion: The main elements that culminated in higher degrees of radiodermatitis were the dose of radiation and the use of daily bolus. By categorizing the predictive factors, we can identify the patient with the highest risk of severe skin lesions and enables the creation of more effective protocols for the prevention of radiodermatitis.Introducción: La radioterapia es una modalidad terapéutica para tratamiento adyuvante y neoadyuvante, en pacientes con cáncer de mama. Tal modalidad provoca reacción de piel dolorosa conocida como radiodermatitis. Objetivo: Evaluar factores conexos con la aparición de radiodermatitis tras la radioterapia y su asociación con el mayor grado de toxicidad. Método: Estudio retrospectivo, con 117 pacientes con cáncer de mama sometidos a la Radioterapia Conformacional 3D entre 2016 a 2018. Los datos personales fueron recolectados a partir de prontuario, así como el grado de radiodermatitis establecido según los criterios del grupo de oncología radioterápica. El total de 15 potencial predictivos fueron enumerados y posteriormente analizados por estadística univariana y multivariada. Resultados: La población del estudio presentó un promedio de 50 años, el 47% informó de algunas comorbilidades, el 59,83% se sometió a cirugía radical y el 81,19% desarrolló radiodermatitis. En un análisis multivariado, hubo una asociación entre el desarrollo de radiodermatitis y dosis más altas de radiación (p=0.011) y el uso diario de bolos (p=0.009). Conclusión: Las principales variables que culminaron en mayores grados de radiodermatitis fueron la dosis de radiación y el uso de bolos diarios. Al categorizar los factores predictivos, podemos identificar al paciente con el mayor riesgo de lesiones cutáneas graves y permitir la creación de protocolos más efectivos para la prevención de la radiodermatitis.Introdução: A radioterapia é uma das modalidades terapêuticas de escolha para os tratamentos adjuvante e neoadjuvante, em pacientes com câncer de mama. Tal modalidade provoca reação de pele dolorosa conhecida como radiodermatite. Objetivo: Avaliar os fatores associados com o aparecimento de radiodermite após radioterapia e a sua associação com o maior grau de toxicidade nesses pacientes. Método: Estudo retrospectivo, com 117 pacientes com de câncer de mama submetidos à radioterapia conformacional 3D, entre 2016 a 2018, em doses variáveis. Dados pessoais foram coletados a partir de prontuário, e o grau de radiodermite estabelecido segundo os critérios do grupo de oncologia radioterápica. O total de 15 potenciais preditivos foram elencados e analisados por estatísticas univariada e multivariada. Resultados: A população do estudo apresentou uma média de 50 anos, 47% relataram alguma comorbidade, 59,83% realizaram cirurgia radical e 81,19% desenvolveram radiodermite. Observou-se, em análise multivariada, associação do desenvolvimento de radiodermite com maiores doses da radiação (p=0,011) e com uso de bólus diário (p=0,009). Conclusão: As principais variáveis que culminaram em maiores graus de radiodermite foram a dose da radiação e o uso de bólus diário. Categorizando os fatores preditivos, identifica-se o paciente com maior risco de lesões graves e a possibilidade da criação de protocolos mais eficazes na prevenção das radiodermatites.INCA2019-06-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/27510.32635/2176-9745.RBC.2019v65n1.275Revista Brasileira de Cancerologia; Vol. 65 No. 1 (2019): Jan./Feb./Mar.; e-05275Revista Brasileira de Cancerologia; Vol. 65 Núm. 1 (2019): enero/feb./marzo; e-05275Revista Brasileira de Cancerologia; v. 65 n. 1 (2019): jan./fev./mar.; e-052752176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/275/183https://rbc.inca.gov.br/index.php/revista/article/view/275/505Copyright (c) 2019 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessCosta, Cássia CardosoLyra, Jorge SoaresNakamura, Ricardo Akiyoshi Sousa, Carine Medeiros de2021-11-29T20:04:27Zoai:rbc.inca.gov.br:article/275Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:04:27Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
Radiodermatitis: Análisis de Factores Predictivos en Pacientes con Cáncer de Mama
Radiodermatites: Análise dos Fatores Preditivos em Pacientes com Câncer de Mama
title Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
spellingShingle Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
Costa, Cássia Cardoso
Radiodermatite
Neoplasias da Mama
Toxicidade Aguda
Radioterapia
Radiodermatitis
Breast Neoplasms
Acute Toxicity
Radiotherapy
Radiodermatitis
Neoplasias de la Mama
Toxicidad Aguda
Radioterapia
title_short Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
title_full Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
title_fullStr Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
title_full_unstemmed Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
title_sort Radiodermatitis: Analysis of Predictive Factors in Breast Cancer Patients
author Costa, Cássia Cardoso
author_facet Costa, Cássia Cardoso
Lyra, Jorge Soares
Nakamura, Ricardo Akiyoshi
Sousa, Carine Medeiros de
author_role author
author2 Lyra, Jorge Soares
Nakamura, Ricardo Akiyoshi
Sousa, Carine Medeiros de
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Cássia Cardoso
Lyra, Jorge Soares
Nakamura, Ricardo Akiyoshi
Sousa, Carine Medeiros de
dc.subject.por.fl_str_mv Radiodermatite
Neoplasias da Mama
Toxicidade Aguda
Radioterapia
Radiodermatitis
Breast Neoplasms
Acute Toxicity
Radiotherapy
Radiodermatitis
Neoplasias de la Mama
Toxicidad Aguda
Radioterapia
topic Radiodermatite
Neoplasias da Mama
Toxicidade Aguda
Radioterapia
Radiodermatitis
Breast Neoplasms
Acute Toxicity
Radiotherapy
Radiodermatitis
Neoplasias de la Mama
Toxicidad Aguda
Radioterapia
description Introduction: Radiotherapy is one of the therapeutic modalities chosen for adjuvant and neoadjuvant treatment in patients with breast cancer. This modality causes a painful skin reaction known as radiodermatitis. Objective: To evaluate the factors related with the appearance of radiodermatitis after radiotherapy and their relationship with the highest degree of toxicity in patients with breast cancer. Method: Retrospective study, with 117 patients with breast cancer submitted to 3D conformational radiotherapy between 2016 and 2018, at variable doses. Personal data were collected from medical records, and the degree of radiodermatitis established according to the criteria of the Radiation Oncology Group. The total of 15 predictive factors in potential were listed and later analyzed by univariate and multivariate statistics. Results: The study population presented an average of 50 years, 47% reported some comorbidities, 59.83% underwent radical surgery and 81.19% developed radiodermatitis. In a multivariate analysis, there was an association between development of radiodermatitis and higher doses of radiation (p=0.011) and daily bolus use (p=0.009). Conclusion: The main elements that culminated in higher degrees of radiodermatitis were the dose of radiation and the use of daily bolus. By categorizing the predictive factors, we can identify the patient with the highest risk of severe skin lesions and enables the creation of more effective protocols for the prevention of radiodermatitis.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/275
10.32635/2176-9745.RBC.2019v65n1.275
url https://rbc.inca.gov.br/index.php/revista/article/view/275
identifier_str_mv 10.32635/2176-9745.RBC.2019v65n1.275
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/275/183
https://rbc.inca.gov.br/index.php/revista/article/view/275/505
dc.rights.driver.fl_str_mv Copyright (c) 2019 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 65 No. 1 (2019): Jan./Feb./Mar.; e-05275
Revista Brasileira de Cancerologia; Vol. 65 Núm. 1 (2019): enero/feb./marzo; e-05275
Revista Brasileira de Cancerologia; v. 65 n. 1 (2019): jan./fev./mar.; e-05275
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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