Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)

Detalhes bibliográficos
Autor(a) principal: Simon , Sergio D.
Data de Publicação: 2023
Outros Autores: Srougi , Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3218
Resumo: Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma.
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spelling Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)Seminoma ChemotherapyAdvanced SeminomaEighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma.INCA2023-08-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/321810.32635/2176-9745.RBC.1987v33n4.3218Revista Brasileira de Cancerologia; Vol. 33 No. 4 (1987): Dec.; 313-315Revista Brasileira de Cancerologia; Vol. 33 Núm. 4 (1987): dic.; 313-315Revista Brasileira de Cancerologia; v. 33 n. 4 (1987): dez.; 313-3152176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/3218/2078https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSimon , Sergio D.Srougi , Miguel2023-08-03T20:13:13Zoai:rbc.inca.gov.br:article/3218Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-03T20:13:13Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
title Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
spellingShingle Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
Simon , Sergio D.
Seminoma Chemotherapy
Advanced Seminoma
title_short Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
title_full Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
title_fullStr Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
title_full_unstemmed Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
title_sort Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
author Simon , Sergio D.
author_facet Simon , Sergio D.
Srougi , Miguel
author_role author
author2 Srougi , Miguel
author2_role author
dc.contributor.author.fl_str_mv Simon , Sergio D.
Srougi , Miguel
dc.subject.por.fl_str_mv Seminoma Chemotherapy
Advanced Seminoma
topic Seminoma Chemotherapy
Advanced Seminoma
description Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3218
10.32635/2176-9745.RBC.1987v33n4.3218
url https://rbc.inca.gov.br/index.php/revista/article/view/3218
identifier_str_mv 10.32635/2176-9745.RBC.1987v33n4.3218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3218/2078
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 33 No. 4 (1987): Dec.; 313-315
Revista Brasileira de Cancerologia; Vol. 33 Núm. 4 (1987): dic.; 313-315
Revista Brasileira de Cancerologia; v. 33 n. 4 (1987): dez.; 313-315
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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