Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3218 |
Resumo: | Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma. |
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Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)Seminoma ChemotherapyAdvanced SeminomaEighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma.INCA2023-08-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/321810.32635/2176-9745.RBC.1987v33n4.3218Revista Brasileira de Cancerologia; Vol. 33 No. 4 (1987): Dec.; 313-315Revista Brasileira de Cancerologia; Vol. 33 Núm. 4 (1987): dic.; 313-315Revista Brasileira de Cancerologia; v. 33 n. 4 (1987): dez.; 313-3152176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/3218/2078https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSimon , Sergio D.Srougi , Miguel2023-08-03T20:13:13Zoai:rbc.inca.gov.br:article/3218Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-03T20:13:13Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
title |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
spellingShingle |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) Simon , Sergio D. Seminoma Chemotherapy Advanced Seminoma |
title_short |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
title_full |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
title_fullStr |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
title_full_unstemmed |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
title_sort |
Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
author |
Simon , Sergio D. |
author_facet |
Simon , Sergio D. Srougi , Miguel |
author_role |
author |
author2 |
Srougi , Miguel |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Simon , Sergio D. Srougi , Miguel |
dc.subject.por.fl_str_mv |
Seminoma Chemotherapy Advanced Seminoma |
topic |
Seminoma Chemotherapy Advanced Seminoma |
description |
Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3218 10.32635/2176-9745.RBC.1987v33n4.3218 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3218 |
identifier_str_mv |
10.32635/2176-9745.RBC.1987v33n4.3218 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3218/2078 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 33 No. 4 (1987): Dec.; 313-315 Revista Brasileira de Cancerologia; Vol. 33 Núm. 4 (1987): dic.; 313-315 Revista Brasileira de Cancerologia; v. 33 n. 4 (1987): dez.; 313-315 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042234794704896 |