Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications

Detalhes bibliográficos
Autor(a) principal: Carvalho Lopes, Juliana
Data de Publicação: 2020
Outros Autores: Pereira Torres, Maria Lúcia
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/400
Resumo: Introduction: Technological advances in recent decades have led to the development of therapeutic approaches in medicine on a new scale of nanometric molecular applications, allowing the establishment of new therapies such as nanotherapy. The use of nanoparticles entails numerous opportunities as well as major challenges for human application where use requires a thorough understanding of the biocompatibility and pharmacodynamics of molecules. In cancer, nanoparticles act mainly in the active forms that are characterized by the use of ligands or antibodies on their surfaces where they bind to certain cells, and in the passive form, where particles accumulate in tumor tissues due to the large fractions of tumor endothelium. Objective: To address the main properties of protein, metal, polymer and lipid nanoparticles, their structures and uses against specific cancer cells and the advantages and disadvantages of their use. Method: Selection of articles with studies on nanoparticles from 2010 to 2018 in the PubMed and SciELO databases through narrative review of the literature. Results: Nanoparticles have different mechanisms of action and may obtain more favorable results according to their chemical structure. Conclusion: Based in this review, it was concluded that certain nanoparticles have functionalities that enhance the anticancer effects of antineoplastic drugs and emerge as a new approach for cancer treatments.
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spelling Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor ApplicationsNanopartículas en el Tratamiento del Cáncer: Aspectos Generales, Mecanismos de Acción Antineoplásicos y Aplicaciones TumoralesUtilização de Nanopartículas no Tratamento do Câncer: Aspectos Gerais, Mecanismos de Ação Antineoplásicos e Aplicabilidades TumoraisNanopartículas/administração & dosagemNanopartículas/uso terapêuticoNeoplasiasAntineoplásicosNanoparticles/administration & dosageNanoparticles/ therapeutic useNeoplasmsAntineoplastic AgentsNanopartículas/administración & dosificaciónNanopartículas/uso terapéuticoNeoplasiasAntineoplásicosIntroduction: Technological advances in recent decades have led to the development of therapeutic approaches in medicine on a new scale of nanometric molecular applications, allowing the establishment of new therapies such as nanotherapy. The use of nanoparticles entails numerous opportunities as well as major challenges for human application where use requires a thorough understanding of the biocompatibility and pharmacodynamics of molecules. In cancer, nanoparticles act mainly in the active forms that are characterized by the use of ligands or antibodies on their surfaces where they bind to certain cells, and in the passive form, where particles accumulate in tumor tissues due to the large fractions of tumor endothelium. Objective: To address the main properties of protein, metal, polymer and lipid nanoparticles, their structures and uses against specific cancer cells and the advantages and disadvantages of their use. Method: Selection of articles with studies on nanoparticles from 2010 to 2018 in the PubMed and SciELO databases through narrative review of the literature. Results: Nanoparticles have different mechanisms of action and may obtain more favorable results according to their chemical structure. Conclusion: Based in this review, it was concluded that certain nanoparticles have functionalities that enhance the anticancer effects of antineoplastic drugs and emerge as a new approach for cancer treatments.Introducción: Los avances tecnológicos en las últimas décadas han llevado al desarrollo de enfoques terapéuticos en medicina en una nueva escala de aplicaciones moleculares nanométricas, lo que permite el establecimiento de nuevas terapias como la nanoterapia. El uso de nanopartículas conlleva numerosas oportunidades, así como desafíos importantes para la aplicación en humanos, este uso requiere un conocimiento profundo de la biocompatibilidad y farmacodinámica de las moléculas. En el cáncer, las nanopartículas actúan principalmente en las formas activas que se caracterizan por el uso de ligandos o anticuerpos en sus superficies donde se unen a ciertas células, y el pasivo, donde las partículas se acumulan en los tejidos tumorales debido a las grandes fracciones del endotelio tumoral. Objetivo: Abordar las principales propiedades de las nanopartículas de proteínas, metales, polímeros y lípidos, sus estructuras y usos contra células cancerosas específicas y las ventajas y desventajas de su uso. Método: Seleccionar artículos con estudios sobre nanopartículas de 2010 a 2018 en las bases de datos PubMed y SciELO, a través de revisión de la literatura integrativa. Resultados: Las nanopartículas tienen diferentes mecanismos de acción y pueden obtener resultados más favorables según su estructura química. Conclusión: Concluido con esta revisión que ciertas nanopartículas tienen funcionalidades que mejoran los efectos anticancerígenos de los fármacos antineoplásicos y emergen como un nuevo enfoque para los tratamientos contra el cáncer.Introdução: Os avanços tecnológicos das últimas décadas levaram ao desenvolvimento de abordagens terapêuticas na medicina em uma nova escala de aplicações moleculares nanométricas, permitindo o estabelecimento de novas terapias como a nanoterapia. O uso de nanopartículas implica inúmeras oportunidades e também grandes desafios para a aplicação humana, esse uso requer uma compreensão minunciosa da biocompatibilidade e da farmacodinâmica das moléculas. No câncer, as nanopartículas atuam principalmente na forma ativa, que se caracteriza pela utilização de ligantes ou anticorpos em suas superfícies onde se ligam a determinadas células, e, na passiva, onde as partículas se acumulam nos tecidos tumorais em razão das largas frenestrações dos endotélios tumorais. Objetivo: Abordar as principais propriedades das nanopartículas de proteína, metal, polímero e lipídio, suas estruturas e utilizações contra células cancerígenas específicas e as vantagens e desvantagens do seu uso. Método: Selecionar artigos com estudos sobre nanopartículas entre os anos de 2010 a 2018 nos bancos de dados PubMed e SciELO por meio de revisão integrativa da literatura. Resultados: As nanopartículas apresentam diferentes mecanismos de ação e podem obter resultados mais favoráveis de acordo com sua estrutura química. Conclusão: Concluiu-se com esta revisão que determinadas nanopartículas apresentam funcionalidades que potencializam os efeitos anticancerígenos dos fármacos antineoplásicos e surgem como uma nova abordagem para tratamentos contra o câncer.INCA2020-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/40010.32635/2176-9745.RBC.2019v65n4.400Revista Brasileira de Cancerologia; Vol. 65 No. 4 (2019): Oct./Nov./Dec.; e-13400Revista Brasileira de Cancerologia; Vol. 65 Núm. 4 (2019): oct./nov./dic.; e-13400Revista Brasileira de Cancerologia; v. 65 n. 4 (2019): out./nov./dez.; e-134002176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/400/536https://rbc.inca.gov.br/index.php/revista/article/view/400/654Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessCarvalho Lopes, JulianaPereira Torres, Maria Lúcia 2021-11-29T20:03:08Zoai:rbc.inca.gov.br:article/400Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:03:08Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
Nanopartículas en el Tratamiento del Cáncer: Aspectos Generales, Mecanismos de Acción Antineoplásicos y Aplicaciones Tumorales
Utilização de Nanopartículas no Tratamento do Câncer: Aspectos Gerais, Mecanismos de Ação Antineoplásicos e Aplicabilidades Tumorais
title Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
spellingShingle Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
Carvalho Lopes, Juliana
Nanopartículas/administração & dosagem
Nanopartículas/uso terapêutico
Neoplasias
Antineoplásicos
Nanoparticles/administration & dosage
Nanoparticles/ therapeutic use
Neoplasms
Antineoplastic Agents
Nanopartículas/administración & dosificación
Nanopartículas/uso terapéutico
Neoplasias
Antineoplásicos
title_short Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
title_full Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
title_fullStr Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
title_full_unstemmed Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
title_sort Nanoparticles in Cancer Treatment: General Aspects, Antineoplastic Mechanisms of Action and Tumor Applications
author Carvalho Lopes, Juliana
author_facet Carvalho Lopes, Juliana
Pereira Torres, Maria Lúcia
author_role author
author2 Pereira Torres, Maria Lúcia
author2_role author
dc.contributor.author.fl_str_mv Carvalho Lopes, Juliana
Pereira Torres, Maria Lúcia
dc.subject.por.fl_str_mv Nanopartículas/administração & dosagem
Nanopartículas/uso terapêutico
Neoplasias
Antineoplásicos
Nanoparticles/administration & dosage
Nanoparticles/ therapeutic use
Neoplasms
Antineoplastic Agents
Nanopartículas/administración & dosificación
Nanopartículas/uso terapéutico
Neoplasias
Antineoplásicos
topic Nanopartículas/administração & dosagem
Nanopartículas/uso terapêutico
Neoplasias
Antineoplásicos
Nanoparticles/administration & dosage
Nanoparticles/ therapeutic use
Neoplasms
Antineoplastic Agents
Nanopartículas/administración & dosificación
Nanopartículas/uso terapéutico
Neoplasias
Antineoplásicos
description Introduction: Technological advances in recent decades have led to the development of therapeutic approaches in medicine on a new scale of nanometric molecular applications, allowing the establishment of new therapies such as nanotherapy. The use of nanoparticles entails numerous opportunities as well as major challenges for human application where use requires a thorough understanding of the biocompatibility and pharmacodynamics of molecules. In cancer, nanoparticles act mainly in the active forms that are characterized by the use of ligands or antibodies on their surfaces where they bind to certain cells, and in the passive form, where particles accumulate in tumor tissues due to the large fractions of tumor endothelium. Objective: To address the main properties of protein, metal, polymer and lipid nanoparticles, their structures and uses against specific cancer cells and the advantages and disadvantages of their use. Method: Selection of articles with studies on nanoparticles from 2010 to 2018 in the PubMed and SciELO databases through narrative review of the literature. Results: Nanoparticles have different mechanisms of action and may obtain more favorable results according to their chemical structure. Conclusion: Based in this review, it was concluded that certain nanoparticles have functionalities that enhance the anticancer effects of antineoplastic drugs and emerge as a new approach for cancer treatments.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/400
10.32635/2176-9745.RBC.2019v65n4.400
url https://rbc.inca.gov.br/index.php/revista/article/view/400
identifier_str_mv 10.32635/2176-9745.RBC.2019v65n4.400
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/400/536
https://rbc.inca.gov.br/index.php/revista/article/view/400/654
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 65 No. 4 (2019): Oct./Nov./Dec.; e-13400
Revista Brasileira de Cancerologia; Vol. 65 Núm. 4 (2019): oct./nov./dic.; e-13400
Revista Brasileira de Cancerologia; v. 65 n. 4 (2019): out./nov./dez.; e-13400
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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