Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review

Detalhes bibliográficos
Autor(a) principal: da Silva Oliveira, Rafaela
Data de Publicação: 2020
Outros Autores: Melo Silva, Waldiene, Joventino Prati, Wesley, Hartuique Rufino, Pablo Carlos, Páscoa da Veiga Frade Santana, Raquel, Kempfer Bassoli, Bruna, da Silva, Francisco Carlos
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/428
Resumo: Introduction: The nuclear factor erythroid 2-related factor 2 (NRF2) plays a fundamental role in the expression of genes mediated by antioxidant response element (ARE), thus it is an important pathway to protect the cells from carcinogenic substances. Objective: To perform an integrative literature review on the quimiopreventive action of phytochemicals through regulation of the transcription factor Nrf2. Method: Search of papers for the integrative literature review about this theme conducted in journals indexed in the databases: Academic Google, PubMed, SciELO, ScienceDirect and Springer Link, using the MeSH descriptors: phytochemicals, free radicals, oxidative stress, carcinogenesis, chemoprevention and Nrf2. The selection criteria were articles published from 2000 to 2019, related to or that directly investigate the role of phytochemicals in the transcription factor Nrf2, and the prevention of cancer development. Results: 58 articles were selected, all related to the objective of the review. The reviewed studies showed that phytochemicals, such as resveratrol, curcumin, isothiocyanate, luteolin, among others, act on the activation of the Nrf2 pathway, using different mechanisms, which are dependent or independent of the repressor protein Kelch-Like Epichlorohydrin-Associated Protein 1. Conclusion: Therefore, the conclusion is that the modulation of the transcription factor Nrf2 is a mechanism that configures itself as an important mediator for harmful compounds to the human organism, and that the action of phytochemicals, in this pathway, contributes to the reduction of cancer risk. However, all the mechanisms used by phytochemicals, are not completely elucidated, and further studies are needed in the area.
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spelling Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature ReviewAcción Quimiopreventiva de los Fitoquímicos a través de la Regulación del Factor de Transcripción Nrf2: Revisión Integradora de la LiteraturaAção Quimiopreventiva dos Fitoquímicos por meio da Regulação do Fator de Transcrição Nrf2: Revisão Integrativa da LiteraturaAntioxidantesCarcinogêneseEstresse OxidativoRadicais LivresRevisãoAntioxidantsCarcinogenesisOxidative StressFree RadicalsReviewAntioxidantesCarcinogénesisEstrés OxidativoRadicales LibresRevisiónIntroduction: The nuclear factor erythroid 2-related factor 2 (NRF2) plays a fundamental role in the expression of genes mediated by antioxidant response element (ARE), thus it is an important pathway to protect the cells from carcinogenic substances. Objective: To perform an integrative literature review on the quimiopreventive action of phytochemicals through regulation of the transcription factor Nrf2. Method: Search of papers for the integrative literature review about this theme conducted in journals indexed in the databases: Academic Google, PubMed, SciELO, ScienceDirect and Springer Link, using the MeSH descriptors: phytochemicals, free radicals, oxidative stress, carcinogenesis, chemoprevention and Nrf2. The selection criteria were articles published from 2000 to 2019, related to or that directly investigate the role of phytochemicals in the transcription factor Nrf2, and the prevention of cancer development. Results: 58 articles were selected, all related to the objective of the review. The reviewed studies showed that phytochemicals, such as resveratrol, curcumin, isothiocyanate, luteolin, among others, act on the activation of the Nrf2 pathway, using different mechanisms, which are dependent or independent of the repressor protein Kelch-Like Epichlorohydrin-Associated Protein 1. Conclusion: Therefore, the conclusion is that the modulation of the transcription factor Nrf2 is a mechanism that configures itself as an important mediator for harmful compounds to the human organism, and that the action of phytochemicals, in this pathway, contributes to the reduction of cancer risk. However, all the mechanisms used by phytochemicals, are not completely elucidated, and further studies are needed in the area.Introducción: El factor nuclear eritroide 2 relacionado con el factor 2 (Nrf2) desenvuelve un papel fundamental en la expresión de los genes mediados por él elemento de respuesta antioxidante (ERA), por lo tanto, es una vía importante para proteger las células de las sustancias carcinógenas. Objetivo: Realizar una revisión integradora de la literatura sobre la acción quimiopreventiva de los fitoquímicos mediante la regulación del factor de transcripción Nrf2. Método: El levantamiento de artículos para la revisión integral de la literatura sobre este tema se realizó en revistas indexadas en las bases de datos: Google Académico, PubMed, Scielo, ScienceDirect y SpringerLink, usando los descriptores MeSH: fitoquímicos, radicales libres, estrés oxidativo, carcinogénesis, quimioprevención y Nrf2. Los criterios de selección fueron artículos publicados entre 2000 y 2019, relacionados o que investigan directamente el papel de los fitoquímicos en el factor de transcripción Nrf2 y la prevención del desarrollo del câncer. Resultados: 58 artículos relacionados con el objetivo de la revisión fueron seleccionados. Los estudios revisados mostraron que los fitoquímicos, como el resveratrol, la curcumina, el isotiocito, la luteolina, entre otros, actúan sobre la activación de la vía Nrf2, utilizando diferentes mecanismos, que son dependientes o independientes de la proteína represora Kelch-Like Epichlorohydrin-Associated Protein 1. Conclusión: Por lo tanto, se concluí que la modulación del factor de transcripción Nrf2 es un mecanismo que se configura como un importante mediador en relación con los compuestos nocivos para el cuerpo humano, y que la acción de los fitoquímicos en esta vía contribuye a reducir el riesgo de cáncer. Sin embargo, todos los mecanismos utilizados por los fitoquímicos aún no se han dilucidado por completo, por lo que se necesitan más estudios en esta área.Introdução: O fator nuclear eritroide 2 relacionado ao fator 2 (Nrf2) desempenha papel fundamental na expressão de genes mediados por elemento de resposta antioxidante (ERA); sendo assim, é uma via importante para proteger as células de substâncias carcinogênicas. Objetivo: Realizar uma revisão integrativa da literatura acerca da ação quimiopreventiva dos fitoquímicos por meio da regulação do fator de transcrição Nrf2. Método: O levantamento de artigos para a revisão integrativa da literatura sobre essa temática foi realizado nos periódicos indexados nas bases de dados: Google Acadêmico, PubMed, SciELO, ScienceDirect e SpringerLink, utilizando-se os descritores advindos do MeSH: fitoquímicos, radicais livres, estresse oxidativo, carcinogênese, quimioprevenção e Nrf2. Os critérios de seleção foram artigos publicados de 2000 a 2019, relacionados, ou que investiguem diretamente a atuação de fitoquímicos no fator de transcrição Nrf2, e a prevenção do desenvolvimento de câncer. Resultados: Foram selecionados 58 artigos que estavam relacionados com o objetivo da revisão. Os estudos revisados apontaram que fitoquímicos, tais como resveratrol, curcumina, isotiocianato, luteolina, entre outros, atuam na ativação da via Nrf2, utilizando diferentes mecanismos, sendo eles dependentes ou independentes da proteína repressora Kelch-Like Epichlorohydrin-Associated Protein 1. Conclusão: Diante disso, conclui-se que a modulação do fator de transcrição Nrf2 é um mecanismo que se configura como um importante mediador no que concerne compostos nocivos ao organismo humano, e que a atuação dos fitoquímicos nessa via contribui para a redução do risco de câncer. No entanto, ainda não são completamente elucidados todos os mecanismos utilizados pelos fitoquímicos, sendo necessários ulteriores estudos na área.INCA2020-03-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/42810.32635/2176-9745.RBC.2020v66n1.428Revista Brasileira de Cancerologia; Vol. 66 No. 1 (2020): Jan./Feb./Mar.; e-07428Revista Brasileira de Cancerologia; Vol. 66 Núm. 1 (2020): enero/feb./marzo; e-07428Revista Brasileira de Cancerologia; v. 66 n. 1 (2020): jan./fev.mar.; e-074282176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/428/559https://rbc.inca.gov.br/index.php/revista/article/view/428/671Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessda Silva Oliveira, RafaelaMelo Silva, WaldieneJoventino Prati, WesleyHartuique Rufino, Pablo CarlosPáscoa da Veiga Frade Santana, RaquelKempfer Bassoli, Brunada Silva, Francisco Carlos2021-11-29T20:02:58Zoai:rbc.inca.gov.br:article/428Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:02:58Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
Acción Quimiopreventiva de los Fitoquímicos a través de la Regulación del Factor de Transcripción Nrf2: Revisión Integradora de la Literatura
Ação Quimiopreventiva dos Fitoquímicos por meio da Regulação do Fator de Transcrição Nrf2: Revisão Integrativa da Literatura
title Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
spellingShingle Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
da Silva Oliveira, Rafaela
Antioxidantes
Carcinogênese
Estresse Oxidativo
Radicais Livres
Revisão
Antioxidants
Carcinogenesis
Oxidative Stress
Free Radicals
Review
Antioxidantes
Carcinogénesis
Estrés Oxidativo
Radicales Libres
Revisión
title_short Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
title_full Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
title_fullStr Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
title_full_unstemmed Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
title_sort Quimiopreventive Action of Phytochemicals through Regulation of Transcription Factor Nrf2: Integrative Literature Review
author da Silva Oliveira, Rafaela
author_facet da Silva Oliveira, Rafaela
Melo Silva, Waldiene
Joventino Prati, Wesley
Hartuique Rufino, Pablo Carlos
Páscoa da Veiga Frade Santana, Raquel
Kempfer Bassoli, Bruna
da Silva, Francisco Carlos
author_role author
author2 Melo Silva, Waldiene
Joventino Prati, Wesley
Hartuique Rufino, Pablo Carlos
Páscoa da Veiga Frade Santana, Raquel
Kempfer Bassoli, Bruna
da Silva, Francisco Carlos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv da Silva Oliveira, Rafaela
Melo Silva, Waldiene
Joventino Prati, Wesley
Hartuique Rufino, Pablo Carlos
Páscoa da Veiga Frade Santana, Raquel
Kempfer Bassoli, Bruna
da Silva, Francisco Carlos
dc.subject.por.fl_str_mv Antioxidantes
Carcinogênese
Estresse Oxidativo
Radicais Livres
Revisão
Antioxidants
Carcinogenesis
Oxidative Stress
Free Radicals
Review
Antioxidantes
Carcinogénesis
Estrés Oxidativo
Radicales Libres
Revisión
topic Antioxidantes
Carcinogênese
Estresse Oxidativo
Radicais Livres
Revisão
Antioxidants
Carcinogenesis
Oxidative Stress
Free Radicals
Review
Antioxidantes
Carcinogénesis
Estrés Oxidativo
Radicales Libres
Revisión
description Introduction: The nuclear factor erythroid 2-related factor 2 (NRF2) plays a fundamental role in the expression of genes mediated by antioxidant response element (ARE), thus it is an important pathway to protect the cells from carcinogenic substances. Objective: To perform an integrative literature review on the quimiopreventive action of phytochemicals through regulation of the transcription factor Nrf2. Method: Search of papers for the integrative literature review about this theme conducted in journals indexed in the databases: Academic Google, PubMed, SciELO, ScienceDirect and Springer Link, using the MeSH descriptors: phytochemicals, free radicals, oxidative stress, carcinogenesis, chemoprevention and Nrf2. The selection criteria were articles published from 2000 to 2019, related to or that directly investigate the role of phytochemicals in the transcription factor Nrf2, and the prevention of cancer development. Results: 58 articles were selected, all related to the objective of the review. The reviewed studies showed that phytochemicals, such as resveratrol, curcumin, isothiocyanate, luteolin, among others, act on the activation of the Nrf2 pathway, using different mechanisms, which are dependent or independent of the repressor protein Kelch-Like Epichlorohydrin-Associated Protein 1. Conclusion: Therefore, the conclusion is that the modulation of the transcription factor Nrf2 is a mechanism that configures itself as an important mediator for harmful compounds to the human organism, and that the action of phytochemicals, in this pathway, contributes to the reduction of cancer risk. However, all the mechanisms used by phytochemicals, are not completely elucidated, and further studies are needed in the area.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/428
10.32635/2176-9745.RBC.2020v66n1.428
url https://rbc.inca.gov.br/index.php/revista/article/view/428
identifier_str_mv 10.32635/2176-9745.RBC.2020v66n1.428
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/428/559
https://rbc.inca.gov.br/index.php/revista/article/view/428/671
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 66 No. 1 (2020): Jan./Feb./Mar.; e-07428
Revista Brasileira de Cancerologia; Vol. 66 Núm. 1 (2020): enero/feb./marzo; e-07428
Revista Brasileira de Cancerologia; v. 66 n. 1 (2020): jan./fev.mar.; e-07428
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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