Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate

Detalhes bibliográficos
Autor(a) principal: Moreira, Wagner Brant
Data de Publicação: 2023
Outros Autores: Brandão, Eduardo Carvalho, Nascimento, Eduardo, Lopes, Eugënio Baumgratz, Teixeira, João Augusto Moreira, Vieira, Maria do Carmo Lima A., Álvares, Maria Nunes, Araújo, Rogërio Agenor, Cabral Filho, Sebastião
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3197
Resumo: Between march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients.
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spelling Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e MethotrexateLinfoma de BurkittQuimioterapiaBurkitt LymphomaChemotherapyBetween march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients.Trinta e três pacientes, portadores de Linfoma de Burkitt, foram tratados no período de março/81 a abril/86, com a associação de Ciclofosfamida, Oncovin e Methotrexate venoso com Methotrexate intratecal. A idade mediana foi de sete meses e a relação sexo foi de 1/1,75 com predominância masculina. Onze pacientes tinham doença mínima (estádios A, B e AR) e 22 doença avançada (estádios C e D). Vinte pacientes entraram em RC (61%) e 12 (36%) permaneceram continuamente sem recidiva. Com relação ao estadiamento, pacientes com doença mínima tiveram 91 % (10/11) RC com sobrevida a 33 meses de 69%; pacientes com doença avançada tiveram 45% (10/22) RC com sobrevida a 33 meses de 27%. Dos 20 pacientes que entraram em RC sete (35%) apresentaram recidiva da doença, sendo dois no SNC, mas um deles já apresentava infiltração meníngea inicial. Dois pacientes (6%) faleceram com a Síndrome de lise tumoral aguda e quatro pacientes (12%) faleceram por intoxicação à quimioterapia; todos estes pacientes eram portadores de doença avançada. O esquema é muito eficaz e pouco tóxico, em pacientes portadores de Linfoma de Burkitt com pouca massa tumoral, mas é pouco eficaz nos pacientes com doença avançada. Novos esquemas devem ser estudados para este subgrupo de pacientes.INCA2023-08-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/319710.32635/2176-9745.RBC.1987v33n2.3197Revista Brasileira de Cancerologia; Vol. 33 No. 2 (1987): June; 133-139Revista Brasileira de Cancerologia; Vol. 33 Núm. 2 (1987): jun.; 133-139Revista Brasileira de Cancerologia; v. 33 n. 2 (1987): jun.; 133-1392176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3197/2050https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoreira, Wagner BrantBrandão, Eduardo CarvalhoNascimento, EduardoLopes, Eugënio BaumgratzTeixeira, João Augusto MoreiraVieira, Maria do Carmo Lima A.Álvares, Maria NunesAraújo, Rogërio AgenorCabral Filho, Sebastião2023-08-04T18:36:06Zoai:rbc.inca.gov.br:article/3197Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-04T18:36:06Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
title Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
spellingShingle Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
Moreira, Wagner Brant
Linfoma de Burkitt
Quimioterapia
Burkitt Lymphoma
Chemotherapy
title_short Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
title_full Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
title_fullStr Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
title_full_unstemmed Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
title_sort Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
author Moreira, Wagner Brant
author_facet Moreira, Wagner Brant
Brandão, Eduardo Carvalho
Nascimento, Eduardo
Lopes, Eugënio Baumgratz
Teixeira, João Augusto Moreira
Vieira, Maria do Carmo Lima A.
Álvares, Maria Nunes
Araújo, Rogërio Agenor
Cabral Filho, Sebastião
author_role author
author2 Brandão, Eduardo Carvalho
Nascimento, Eduardo
Lopes, Eugënio Baumgratz
Teixeira, João Augusto Moreira
Vieira, Maria do Carmo Lima A.
Álvares, Maria Nunes
Araújo, Rogërio Agenor
Cabral Filho, Sebastião
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, Wagner Brant
Brandão, Eduardo Carvalho
Nascimento, Eduardo
Lopes, Eugënio Baumgratz
Teixeira, João Augusto Moreira
Vieira, Maria do Carmo Lima A.
Álvares, Maria Nunes
Araújo, Rogërio Agenor
Cabral Filho, Sebastião
dc.subject.por.fl_str_mv Linfoma de Burkitt
Quimioterapia
Burkitt Lymphoma
Chemotherapy
topic Linfoma de Burkitt
Quimioterapia
Burkitt Lymphoma
Chemotherapy
description Between march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-04
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3197
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url https://rbc.inca.gov.br/index.php/revista/article/view/3197
identifier_str_mv 10.32635/2176-9745.RBC.1987v33n2.3197
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3197/2050
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dc.publisher.none.fl_str_mv INCA
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dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 33 No. 2 (1987): June; 133-139
Revista Brasileira de Cancerologia; Vol. 33 Núm. 2 (1987): jun.; 133-139
Revista Brasileira de Cancerologia; v. 33 n. 2 (1987): jun.; 133-139
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
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instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
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