Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3197 |
Resumo: | Between march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients. |
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Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e MethotrexateLinfoma de BurkittQuimioterapiaBurkitt LymphomaChemotherapyBetween march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients.Trinta e três pacientes, portadores de Linfoma de Burkitt, foram tratados no período de março/81 a abril/86, com a associação de Ciclofosfamida, Oncovin e Methotrexate venoso com Methotrexate intratecal. A idade mediana foi de sete meses e a relação sexo foi de 1/1,75 com predominância masculina. Onze pacientes tinham doença mínima (estádios A, B e AR) e 22 doença avançada (estádios C e D). Vinte pacientes entraram em RC (61%) e 12 (36%) permaneceram continuamente sem recidiva. Com relação ao estadiamento, pacientes com doença mínima tiveram 91 % (10/11) RC com sobrevida a 33 meses de 69%; pacientes com doença avançada tiveram 45% (10/22) RC com sobrevida a 33 meses de 27%. Dos 20 pacientes que entraram em RC sete (35%) apresentaram recidiva da doença, sendo dois no SNC, mas um deles já apresentava infiltração meníngea inicial. Dois pacientes (6%) faleceram com a Síndrome de lise tumoral aguda e quatro pacientes (12%) faleceram por intoxicação à quimioterapia; todos estes pacientes eram portadores de doença avançada. O esquema é muito eficaz e pouco tóxico, em pacientes portadores de Linfoma de Burkitt com pouca massa tumoral, mas é pouco eficaz nos pacientes com doença avançada. Novos esquemas devem ser estudados para este subgrupo de pacientes.INCA2023-08-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/319710.32635/2176-9745.RBC.1987v33n2.3197Revista Brasileira de Cancerologia; Vol. 33 No. 2 (1987): June; 133-139Revista Brasileira de Cancerologia; Vol. 33 Núm. 2 (1987): jun.; 133-139Revista Brasileira de Cancerologia; v. 33 n. 2 (1987): jun.; 133-1392176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3197/2050https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoreira, Wagner BrantBrandão, Eduardo CarvalhoNascimento, EduardoLopes, Eugënio BaumgratzTeixeira, João Augusto MoreiraVieira, Maria do Carmo Lima A.Álvares, Maria NunesAraújo, Rogërio AgenorCabral Filho, Sebastião2023-08-04T18:36:06Zoai:rbc.inca.gov.br:article/3197Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-04T18:36:06Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
title |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
spellingShingle |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate Moreira, Wagner Brant Linfoma de Burkitt Quimioterapia Burkitt Lymphoma Chemotherapy |
title_short |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
title_full |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
title_fullStr |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
title_full_unstemmed |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
title_sort |
Resultados do Tratamento do Linfoma de Burkitt com a Associação de Ciclofosfamida, Vincristina e Methotrexate |
author |
Moreira, Wagner Brant |
author_facet |
Moreira, Wagner Brant Brandão, Eduardo Carvalho Nascimento, Eduardo Lopes, Eugënio Baumgratz Teixeira, João Augusto Moreira Vieira, Maria do Carmo Lima A. Álvares, Maria Nunes Araújo, Rogërio Agenor Cabral Filho, Sebastião |
author_role |
author |
author2 |
Brandão, Eduardo Carvalho Nascimento, Eduardo Lopes, Eugënio Baumgratz Teixeira, João Augusto Moreira Vieira, Maria do Carmo Lima A. Álvares, Maria Nunes Araújo, Rogërio Agenor Cabral Filho, Sebastião |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moreira, Wagner Brant Brandão, Eduardo Carvalho Nascimento, Eduardo Lopes, Eugënio Baumgratz Teixeira, João Augusto Moreira Vieira, Maria do Carmo Lima A. Álvares, Maria Nunes Araújo, Rogërio Agenor Cabral Filho, Sebastião |
dc.subject.por.fl_str_mv |
Linfoma de Burkitt Quimioterapia Burkitt Lymphoma Chemotherapy |
topic |
Linfoma de Burkitt Quimioterapia Burkitt Lymphoma Chemotherapy |
description |
Between march/81 to april/86 thirty-three Burkitt's Lymphoma patients were treated at our Instituition with combination Chemotherapy containing intravenous administration of Cyclophosphamide, Vincristine and Methotrexate and in trathecal injections of Methotrexate as described byZiegler in 1977. Patients median age was 7 years and the sex ratio (malo/female) was 1.75/1.0. Eleven patients had minimal disease (stages A, B and AR) and 22 advanced disease (stages C ando). Twenty patients achieved complete remission (61%) and 12 (36%) of them were continuously disease-free. Ten of 11(91%) patients with minimal disease achieved complete remission and had a 33 months survival of 69%; 10/22(45%) patients with advanced disease achieved complete remission with a 33 months survival of 27%. Between the 20 complete remission patients, 7 (35%) recurred; 2 of them at the CNS. Two patients (6%) died with acute tumor cell lysis syndrome and 4 died with direct chemotherapy intoxication; alI of them had advanced disease. This association of Chemotherapy has proved to be very useful in patients with minimal tumor burden but has achieved poor results in patients with massive disease. New associations and dosages are necessary to be studied in this subset of patients. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3197 10.32635/2176-9745.RBC.1987v33n2.3197 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3197 |
identifier_str_mv |
10.32635/2176-9745.RBC.1987v33n2.3197 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3197/2050 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 33 No. 2 (1987): June; 133-139 Revista Brasileira de Cancerologia; Vol. 33 Núm. 2 (1987): jun.; 133-139 Revista Brasileira de Cancerologia; v. 33 n. 2 (1987): jun.; 133-139 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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