Multifocal Breast Cancer: Case Report

Detalhes bibliográficos
Autor(a) principal: Chielli, Gabriela
Data de Publicação: 2020
Outros Autores: Borges, João Ramalho, Martins, Gabriel Lucas, Lacerda, Thiago Fernandes de, Lombardi, Welington, Lombardi, Luciana Borges
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/956
Resumo: Introduction: Breast cancer is the neoplasm that most affects females, being the first cause of death by cancer in women. Breast carcinoma is a heterogeneous group of diseases. Individual cases differ from each other in morphology, phenotype and prognosis. Malignant breast pathologies can manifest as single, multifocal and/or multicentric tumors. The incidence of multifocal and multicentric tumors in breast cancer varies from 13% to 70%. Case report: Patient L.C., female, 65 years old, with a palpable nodule in the right breast in September 2015. The anatomopathological study of the nodule showed intraductal carcinoma. She underwent quadrantectomy, with anatomopathological examination that identified well-differentiated intracystic and invasive papillary carcinoma of the breast, associated with a cribriform and papillary intraductal component, with free sentinel lymph node and margins and immunohistochemistry compatible with triple negative profile. In February 2019, she presented two new lesions in contralateral breast, identified as invasive multifocal ductal carcinoma, with associated intraductal papilloma, and invasive ductal carcinoma, associated with an in situ intraductal component of the papillary, solid and cribriform types, with immunohistochemistry with different molecular profiles, being one lesion classified as luminal A and the other, hybrid luminal. Conclusion: This study reports a case of a patient who had neoplastic lesions in both breasts, at different times and with distinctive histological and immunohistochemical profiles. Thus, the rarity of the case and the relevance of the therapy aimed at specific targets are highlighted, since the patient presented lesions with different molecular profiles.
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spelling Multifocal Breast Cancer: Case ReportCáncer de Mama Multifocal: Relato de casoCâncer de Mama Multifocal: Relato de CasoNeoplasias da MamaCarcinoma Ductal de MamaMastectomia SegmentarQuimioterapia AdjuvanteRadioterapia AdjuvanteBreast NeoplasmsCarcinoma, Ductal, BreastMastectomy, SegmentalChemotherapy, AdjuvantRadiotherapy, AdjuvantNeoplasias de la MamaCarcinoma Ductal de MamaMastectomía SegmentariaQuimioterapia AdyuvantRadioterapia AyuvanteIntroduction: Breast cancer is the neoplasm that most affects females, being the first cause of death by cancer in women. Breast carcinoma is a heterogeneous group of diseases. Individual cases differ from each other in morphology, phenotype and prognosis. Malignant breast pathologies can manifest as single, multifocal and/or multicentric tumors. The incidence of multifocal and multicentric tumors in breast cancer varies from 13% to 70%. Case report: Patient L.C., female, 65 years old, with a palpable nodule in the right breast in September 2015. The anatomopathological study of the nodule showed intraductal carcinoma. She underwent quadrantectomy, with anatomopathological examination that identified well-differentiated intracystic and invasive papillary carcinoma of the breast, associated with a cribriform and papillary intraductal component, with free sentinel lymph node and margins and immunohistochemistry compatible with triple negative profile. In February 2019, she presented two new lesions in contralateral breast, identified as invasive multifocal ductal carcinoma, with associated intraductal papilloma, and invasive ductal carcinoma, associated with an in situ intraductal component of the papillary, solid and cribriform types, with immunohistochemistry with different molecular profiles, being one lesion classified as luminal A and the other, hybrid luminal. Conclusion: This study reports a case of a patient who had neoplastic lesions in both breasts, at different times and with distinctive histological and immunohistochemical profiles. Thus, the rarity of the case and the relevance of the therapy aimed at specific targets are highlighted, since the patient presented lesions with different molecular profiles.Introducción: El cáncer de mama es la neoplasia que más afecta a las mujeres, siendo la primera causa de muerte por cáncer en las mujeres. El carcinoma de mama representa un grupo heterogéneo de enfermedades. Los casos individuales difieren entre sí en morfología, fenotipo y pronóstico. Las patologías mamarias malignas pueden manifestarse como tumores únicos, multifocales y/o multicéntricos. La incidencia de tumores multifocales y multicéntricos en el cáncer de mama varía del 13% al 70%. Relato del caso: Paciente L.C., mujer, 65 años, con un nódulo palpable en el seno derecho en septiembre de 2015. El estudio anatomopatológico de la lesión mostró carcinoma intraductal. La paciente se sometió a una cuadrantectomía, con un examen anatomopatológico que identificó un carcinoma papilar invasivo e intraquístico bien diferenciado de mama, asociado con un componente intraductal cribiforme y papilar, con ganglio linfático y márgens libres y inmunohistoquímica compatible con perfil triple negativo. En febrero de 2019, presentó dos nuevas lesiones en el seno contralateral, identificadas como carcinoma ductal multifocal invasivo, con papiloma intraductal asociado y carcinoma ductal invasivo, asociado con un componente intraductal in situ de los tipos papilar, sólido y cribiforme, con inmunohistoquímica con diferentes perfiles moleculares, siendo una lesión del tipo luminal A y la otra, luminal híbrida. Conclusión: Este estudio reporta un caso de una paciente que tenía lesiones neoplásicas en ambos senos, en diferentes momentos y con diferentes perfiles histológicos e inmunohistoquímicos. Por lo tanto, se destaca la rareza del caso y la relevancia de la terapia dirigida a objetivos específicos, una vez que la paciente presentó lesiones con diferentes perfiles moleculares.Introdução: O câncer de mama é a neoplasia que mais acomete o sexo feminino, sendo a primeira causa de morte por câncer em mulheres. O carcinoma mamário representa um grupo heterogêneo de doenças. Casos individuais diferem uns dos outros na morfologia, fenótipo e prognóstico. As patologias malignas das mamas podem se manifestar como tumores unifocais, multifocais e/ou multicêntricos. A incidência de tumores multifocais e multicêntricos no câncer de mama varia de 13% a 70%. Relato do caso: Paciente L.C., sexo feminino, 65 anos, com relato de nódulo palpável em mama direita em setembro de 2015. O estudo anatomopatológico do nódulo mostrou carcinoma intraductal. Realizada quadrantectomia, com anatomopatológico que identificou carcinoma papilífero bem diferenciado intracístico e invasivo da mama, associado a componente intraductal cribriforme e papilar, com margens e linfonodo sentinela livres e imuno-histoquímica compatível com perfil triplo-negativo. Em fevereiro de 2019, apresentou duas novas lesões em mama contralateral, identificadas como carcinoma ductal invasivo multifocal com papiloma intraductal associado, e carcinoma ductal invasivo associado a componente intraductal in situ dos tipos papilar, sólido e cribriforme, com imuno-histoquímica com perfis moleculares distintos entre si, sendo uma lesão do tipo luminal A e a outra, luminal híbrido. Conclusão: Este estudo relata um caso de uma paciente que apresentou lesões neoplásicas em ambas as mamas, em tempos distintos e com perfis histológicos e imuno-histoquímicos diferentes. Dessa forma, destacam-se a raridade do caso e a relevância da terapia dirigida a alvos específicos, uma vez que a paciente apresentava lesões com perfis moleculares distintos.INCA2020-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/95610.32635/2176-9745.RBC.2020v66n4.956Revista Brasileira de Cancerologia; Vol. 66 No. 4 (2020): Oct./Nov./Dec.; e-15956Revista Brasileira de Cancerologia; Vol. 66 Núm. 4 (2020): oct./nov./dic.; e-15956Revista Brasileira de Cancerologia; v. 66 n. 4 (2020): out./nov./dez.; e-159562176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/956/767https://rbc.inca.gov.br/index.php/revista/article/view/956/925Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessChielli, GabrielaBorges, João Ramalho Martins, Gabriel Lucas Lacerda, Thiago Fernandes de Lombardi, Welington Lombardi, Luciana Borges 2021-11-29T18:29:34Zoai:rbc.inca.gov.br:article/956Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:29:34Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Multifocal Breast Cancer: Case Report
Cáncer de Mama Multifocal: Relato de caso
Câncer de Mama Multifocal: Relato de Caso
title Multifocal Breast Cancer: Case Report
spellingShingle Multifocal Breast Cancer: Case Report
Chielli, Gabriela
Neoplasias da Mama
Carcinoma Ductal de Mama
Mastectomia Segmentar
Quimioterapia Adjuvante
Radioterapia Adjuvante
Breast Neoplasms
Carcinoma, Ductal, Breast
Mastectomy, Segmental
Chemotherapy, Adjuvant
Radiotherapy, Adjuvant
Neoplasias de la Mama
Carcinoma Ductal de Mama
Mastectomía Segmentaria
Quimioterapia Adyuvant
Radioterapia Ayuvante
title_short Multifocal Breast Cancer: Case Report
title_full Multifocal Breast Cancer: Case Report
title_fullStr Multifocal Breast Cancer: Case Report
title_full_unstemmed Multifocal Breast Cancer: Case Report
title_sort Multifocal Breast Cancer: Case Report
author Chielli, Gabriela
author_facet Chielli, Gabriela
Borges, João Ramalho
Martins, Gabriel Lucas
Lacerda, Thiago Fernandes de
Lombardi, Welington
Lombardi, Luciana Borges
author_role author
author2 Borges, João Ramalho
Martins, Gabriel Lucas
Lacerda, Thiago Fernandes de
Lombardi, Welington
Lombardi, Luciana Borges
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Chielli, Gabriela
Borges, João Ramalho
Martins, Gabriel Lucas
Lacerda, Thiago Fernandes de
Lombardi, Welington
Lombardi, Luciana Borges
dc.subject.por.fl_str_mv Neoplasias da Mama
Carcinoma Ductal de Mama
Mastectomia Segmentar
Quimioterapia Adjuvante
Radioterapia Adjuvante
Breast Neoplasms
Carcinoma, Ductal, Breast
Mastectomy, Segmental
Chemotherapy, Adjuvant
Radiotherapy, Adjuvant
Neoplasias de la Mama
Carcinoma Ductal de Mama
Mastectomía Segmentaria
Quimioterapia Adyuvant
Radioterapia Ayuvante
topic Neoplasias da Mama
Carcinoma Ductal de Mama
Mastectomia Segmentar
Quimioterapia Adjuvante
Radioterapia Adjuvante
Breast Neoplasms
Carcinoma, Ductal, Breast
Mastectomy, Segmental
Chemotherapy, Adjuvant
Radiotherapy, Adjuvant
Neoplasias de la Mama
Carcinoma Ductal de Mama
Mastectomía Segmentaria
Quimioterapia Adyuvant
Radioterapia Ayuvante
description Introduction: Breast cancer is the neoplasm that most affects females, being the first cause of death by cancer in women. Breast carcinoma is a heterogeneous group of diseases. Individual cases differ from each other in morphology, phenotype and prognosis. Malignant breast pathologies can manifest as single, multifocal and/or multicentric tumors. The incidence of multifocal and multicentric tumors in breast cancer varies from 13% to 70%. Case report: Patient L.C., female, 65 years old, with a palpable nodule in the right breast in September 2015. The anatomopathological study of the nodule showed intraductal carcinoma. She underwent quadrantectomy, with anatomopathological examination that identified well-differentiated intracystic and invasive papillary carcinoma of the breast, associated with a cribriform and papillary intraductal component, with free sentinel lymph node and margins and immunohistochemistry compatible with triple negative profile. In February 2019, she presented two new lesions in contralateral breast, identified as invasive multifocal ductal carcinoma, with associated intraductal papilloma, and invasive ductal carcinoma, associated with an in situ intraductal component of the papillary, solid and cribriform types, with immunohistochemistry with different molecular profiles, being one lesion classified as luminal A and the other, hybrid luminal. Conclusion: This study reports a case of a patient who had neoplastic lesions in both breasts, at different times and with distinctive histological and immunohistochemical profiles. Thus, the rarity of the case and the relevance of the therapy aimed at specific targets are highlighted, since the patient presented lesions with different molecular profiles.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/956
10.32635/2176-9745.RBC.2020v66n4.956
url https://rbc.inca.gov.br/index.php/revista/article/view/956
identifier_str_mv 10.32635/2176-9745.RBC.2020v66n4.956
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/956/767
https://rbc.inca.gov.br/index.php/revista/article/view/956/925
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 66 No. 4 (2020): Oct./Nov./Dec.; e-15956
Revista Brasileira de Cancerologia; Vol. 66 Núm. 4 (2020): oct./nov./dic.; e-15956
Revista Brasileira de Cancerologia; v. 66 n. 4 (2020): out./nov./dez.; e-15956
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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