Pharmacology of L-arginine in cancer patients

Detalhes bibliográficos
Autor(a) principal: Novaes, Maria Rita Carvalho Garbi
Data de Publicação: 2004
Outros Autores: Beal, Fabiani Lage Rodrigues
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2010
Resumo: Cancer has been one of the main causes of death in the world and it is considered a serious public health problem. The use of amounts of arginine in the nutritional support of the cancer patient has been evaluated not only as a simple nitrogen enhancer, but also considering the pharmacological effects of this amino acid. The aim of this work is to develop a critical analysis of papers published in indexed journals (Medline, Lilacs, NCBI and Cochrane databases) which evaluated pharmacological effects of arginine in patients with cancer. Although the effects of arginine supplementation in experimental studies are already known, the clinical investigation are insufficient and controversial to affirm that the formulas containing this amino acid generate beneficial effects in the immunological system, in the time of survival, in the weight increase, in the tumor growth and in the incidence of metastasis in cancer patients. Controlled clinical studies are needed to establish criteria for the therapeutical use of arginine in patients with different types of cancer.
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spelling Pharmacology of L-arginine in cancer patientsFarmacologia da L-arginina em pacientes com câncerL-argininaNeoplasiasFarmacologiaSuplementação alimentarArginineNeoplasmsPharmacologySupplementary feedingCancer has been one of the main causes of death in the world and it is considered a serious public health problem. The use of amounts of arginine in the nutritional support of the cancer patient has been evaluated not only as a simple nitrogen enhancer, but also considering the pharmacological effects of this amino acid. The aim of this work is to develop a critical analysis of papers published in indexed journals (Medline, Lilacs, NCBI and Cochrane databases) which evaluated pharmacological effects of arginine in patients with cancer. Although the effects of arginine supplementation in experimental studies are already known, the clinical investigation are insufficient and controversial to affirm that the formulas containing this amino acid generate beneficial effects in the immunological system, in the time of survival, in the weight increase, in the tumor growth and in the incidence of metastasis in cancer patients. Controlled clinical studies are needed to establish criteria for the therapeutical use of arginine in patients with different types of cancer.O câncer tem sido uma das principais causas de morte em todo o mundo e é considerado um sério problema de saúde pública. A suplementação de L-arginina no suporte nutricional do portador de câncer tem sido avaliada como substrato para o implemento do sistema imunólogico de portadores de câncer. O objetivo deste trabalho foi realizar uma análise crítica das pesquisas publicadas, em periódicos indexados nas bases de dados Medline, Lilacs, NCBI e Cochrane que avaliaram os efeitos farmacológicos da L-arginina em pacientes com câncer. Os efeitos da suplementação com L-arginina em estudos experimentais têm sido promissores, porém as investigações clínicas são insuficientes e controversas para se afirmar que esse aminoácido exerça efeito benéfico no sistema imunológico, no tempo de sobrevida, no ganho ponderal, no menor crescimento tumoral e na incidência de metástase em portadores de câncer. A realização de estudos clínicos controlados são necessários para estabelecer os critérios para a utilização terapêutica da L-arginina em pacientes com diferentes tipos de câncer.INCA2004-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/201010.32635/2176-9745.RBC.2004v50n4.2010Revista Brasileira de Cancerologia; Vol. 50 No. 4 (2004): Oct./Nov./Dec.; 321-325Revista Brasileira de Cancerologia; Vol. 50 Núm. 4 (2004): oct./nov./dic.; 321-325Revista Brasileira de Cancerologia; v. 50 n. 4 (2004): out./nov./dez.; 321-3252176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2010/1232Novaes, Maria Rita Carvalho GarbiBeal, Fabiani Lage Rodriguesinfo:eu-repo/semantics/openAccess2021-11-29T20:31:48Zoai:rbc.inca.gov.br:article/2010Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:31:48Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Pharmacology of L-arginine in cancer patients
Farmacologia da L-arginina em pacientes com câncer
title Pharmacology of L-arginine in cancer patients
spellingShingle Pharmacology of L-arginine in cancer patients
Novaes, Maria Rita Carvalho Garbi
L-arginina
Neoplasias
Farmacologia
Suplementação alimentar
Arginine
Neoplasms
Pharmacology
Supplementary feeding
title_short Pharmacology of L-arginine in cancer patients
title_full Pharmacology of L-arginine in cancer patients
title_fullStr Pharmacology of L-arginine in cancer patients
title_full_unstemmed Pharmacology of L-arginine in cancer patients
title_sort Pharmacology of L-arginine in cancer patients
author Novaes, Maria Rita Carvalho Garbi
author_facet Novaes, Maria Rita Carvalho Garbi
Beal, Fabiani Lage Rodrigues
author_role author
author2 Beal, Fabiani Lage Rodrigues
author2_role author
dc.contributor.author.fl_str_mv Novaes, Maria Rita Carvalho Garbi
Beal, Fabiani Lage Rodrigues
dc.subject.por.fl_str_mv L-arginina
Neoplasias
Farmacologia
Suplementação alimentar
Arginine
Neoplasms
Pharmacology
Supplementary feeding
topic L-arginina
Neoplasias
Farmacologia
Suplementação alimentar
Arginine
Neoplasms
Pharmacology
Supplementary feeding
description Cancer has been one of the main causes of death in the world and it is considered a serious public health problem. The use of amounts of arginine in the nutritional support of the cancer patient has been evaluated not only as a simple nitrogen enhancer, but also considering the pharmacological effects of this amino acid. The aim of this work is to develop a critical analysis of papers published in indexed journals (Medline, Lilacs, NCBI and Cochrane databases) which evaluated pharmacological effects of arginine in patients with cancer. Although the effects of arginine supplementation in experimental studies are already known, the clinical investigation are insufficient and controversial to affirm that the formulas containing this amino acid generate beneficial effects in the immunological system, in the time of survival, in the weight increase, in the tumor growth and in the incidence of metastasis in cancer patients. Controlled clinical studies are needed to establish criteria for the therapeutical use of arginine in patients with different types of cancer.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2010
10.32635/2176-9745.RBC.2004v50n4.2010
url https://rbc.inca.gov.br/index.php/revista/article/view/2010
identifier_str_mv 10.32635/2176-9745.RBC.2004v50n4.2010
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2010/1232
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 50 No. 4 (2004): Oct./Nov./Dec.; 321-325
Revista Brasileira de Cancerologia; Vol. 50 Núm. 4 (2004): oct./nov./dic.; 321-325
Revista Brasileira de Cancerologia; v. 50 n. 4 (2004): out./nov./dez.; 321-325
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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