Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/587 |
Resumo: | Introduction: Cervical Intraepithelial Neoplasia (CIN), when untreated, is likely to progress to cancer, persists as CIN, or regresses to a normal tissue. Objective: To determine the pattern of natural evolution of precancerous lesions of the cervix, and to evaluate the role of co-factors on the risk of cervical cancer development in a cohort of women from Rio de Janeiro, Brazil. Method: An exploratory study was carried out in 227 women with precancerous lesions referred from the Cervical Pathology Center from 1998 to 2000. The evolution of precancerous lesions was ascertained in patients who were left untreated for presenting clinical limitations. Patients were followed for two years, with a cytological exam. Cytological results were classified as follows: Low grade Squamous Intraepithelial Lesion (LSIL), high grade Squamous Intraepithelial Lesion (HSIL). Likelihood and risk of regression, persistence and progression of precancerous lesions were determined using the Kaplan Meier test (L-R:95%) and the Proportional Cox Regression test. Results: The lesion regression likelihood was the following: 46% (LSIL), 72.8% (HSIL). HSIL was more likely to persist (43.1%) and progress to cervical cancer (7.1%) than LSIL. Women <30 years were more likely to regress (79.9%) than older women, and women ≥50 were more likely to show lesion persistence (43.3%) and to progress to cervical cancer (31.8%) than younger women. Conclusion: Women <30 years at diagnosis of LSIL were more likely to regress than older women, and women ≥50 years with HSIL were at higher risk persistence and progression, when compared to younger women. |
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Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, BrazilHistoria Natural de las Lesiones Precursoras del Cáncer del Cuello del Útero: un Estudio Exploratorio de una Cohorte de Mujeres de Río de Janeiro - RJ, BrasilHistória Natural de Lesões Precursoras do Câncer do Colo do Útero: Estudo Exploratório de uma Coorte de Mulheres do Rio de Janeiro - RJ, BrasilNeoplasias do Colo do Útero/epidemiologiaLesões Pré-CancerosasNeoplasia Intra-Epitelial CervicalHistória Natural das DoençasUterine Cervical Neoplasms/epidemiologyPrecancerous ConditionsCervical Intraepithelial NeoplasiaNatural History of DiseasesNeoplasias del Cuello Uterino/epidemiologíaLesiones PrecancerosasNeoplasia Intraepitelial del Cuello UterinoHistoria Natural de las EnfermedadesIntroduction: Cervical Intraepithelial Neoplasia (CIN), when untreated, is likely to progress to cancer, persists as CIN, or regresses to a normal tissue. Objective: To determine the pattern of natural evolution of precancerous lesions of the cervix, and to evaluate the role of co-factors on the risk of cervical cancer development in a cohort of women from Rio de Janeiro, Brazil. Method: An exploratory study was carried out in 227 women with precancerous lesions referred from the Cervical Pathology Center from 1998 to 2000. The evolution of precancerous lesions was ascertained in patients who were left untreated for presenting clinical limitations. Patients were followed for two years, with a cytological exam. Cytological results were classified as follows: Low grade Squamous Intraepithelial Lesion (LSIL), high grade Squamous Intraepithelial Lesion (HSIL). Likelihood and risk of regression, persistence and progression of precancerous lesions were determined using the Kaplan Meier test (L-R:95%) and the Proportional Cox Regression test. Results: The lesion regression likelihood was the following: 46% (LSIL), 72.8% (HSIL). HSIL was more likely to persist (43.1%) and progress to cervical cancer (7.1%) than LSIL. Women <30 years were more likely to regress (79.9%) than older women, and women ≥50 were more likely to show lesion persistence (43.3%) and to progress to cervical cancer (31.8%) than younger women. Conclusion: Women <30 years at diagnosis of LSIL were more likely to regress than older women, and women ≥50 years with HSIL were at higher risk persistence and progression, when compared to younger women. Introducción: Cuando la Neoplasia Intraepitelial Cervical (NIC) no es tratada puede evolucionar en cáncer, persistir como NIC o retroceder a tejido normal. Objetivo: Determinar el patrón de evolución natural de las lesiones precursoras del cáncer del cuello del útero y evaluar el papel de cofactores de riesgo del cancer del cuello del útero en una cohorte de mujeres de Rio de Janeiro, Brasil. Método: Se ha realizado un estudio en 227 mujeres con NIC referidas a partir del Centro de Patología Cervical (1998-2000). La evolución de las NIC fue verificada en pacientes que no han sido tratadas debido a limitaciones clínicas, que fueron seguidas por dos años con pruebas citológicas. Los resultados citológicos han sido clasificados como: lesiones de bajo grado (LBG) y lesiones de alto grado (LA G). Probalidad y riesgo de retrocesión, persistencia y progresión de las lesiones precancerosas han sido determinadas mediante prueba de Kaplan Meier (L-R: 95%) y regresión de Cox proporcional. Resultados: La probabilidad de regresión de la lesión fue 46% para LBG y 72.8% para LAG. Las LAG presentaron mayor probabilidad de progresión para el cáncer (7.1%) y persistencia (43.1%) que las LBG. Las mujeres <30 años presentaron mayor probabilidad de regresión (79.9%) que las mujeres más mayores, y mujeres ≥50 años eran más propensas de presentar lesión persistente (43.3%) que las mujeres más jovenes (31.8%). Conclusión: Mujeres <30 años en el diagnóstico de LGB eran más propensas a retrocesión que mujeres más mayores, mientras que mujeres≥50 años con HSIL estaban más sujetas a tener lesiones persistentes y progresión que la mujeres más jovenes. Introdução: Neoplasia de Itraepitelial Cervical (NIC ) quando não tratada progride para câncer, persiste como NIC ou regride para um tecido normal. Objetivo: Determinar o padrão de evolução natural das lesões precursoras do câncer cervical e avaliar o papel de cofatores sobre o risco de desenvolvimento dessa neoplasia numa coorte de mulheres do Rio de Janeiro, Brasil. Método: Foi feito um estudo exploratório em 227 mulheres com NIC referidas a partir do Centro de Patologia Cervical, de 1998 2000. A evolução das NIC foi verificada em pacientes que foram deixadas sem tratamento por apresentarem limitações clínicas, que foram seguidas por dois anos com exames citológicos. Resultados citológicos foram classificados como: Lesão de Baixo Grau (LBG), Lesão de Alto Grau (LA G). Probabilidade e risco de regressão, persistência e progressão das lesões pré-cancerosas foram determinados usando test (L-R:95%) de Kaplan Meier e regressão de Cox proporcional. Resultados: A probabilidade de regressão da lesão foi: 46% (LBG), 72,8% (LAG). As LAG apresentaram maior probabilidadde de progressão para câncer (7,1%) e persistência (43,1%) do que LBG. Mulheres <30 anos eram mais propensas a regredir (79,9%) do que as mulheres mais velhas. Mulheres≥50 eram mais prováveis de apresentar lesão persistente (43,3%) do que as mulheres mais jovens (31,8%). Conclusão: Mulheres < 30 anos no diagnóstico de LBG eram mais propensas a regredir do que as mulheres mais velhas. Mulheres com≥50 anos com HSIL eram mais sujeitas a ter lesões persistentes e progredirem, em comparação as mais jovens.INCA2012-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/58710.32635/2176-9745.RBC.2012v58n3.587Revista Brasileira de Cancerologia; Vol. 58 No. 3 (2012): July/Aug./Sept.; 369-378Revista Brasileira de Cancerologia; Vol. 58 Núm. 3 (2012): jul./ago./sept.; 369-378Revista Brasileira de Cancerologia; v. 58 n. 3 (2012): jul./ago./set. ; 369-3782176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/587/362https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Ilce Ferreira da Koifman, Rosalina Jorge Koifman, Sergio Mattos, Inês Echenique 2023-07-24T18:37:48Zoai:rbc.inca.gov.br:article/587Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-07-24T18:37:48Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil Historia Natural de las Lesiones Precursoras del Cáncer del Cuello del Útero: un Estudio Exploratorio de una Cohorte de Mujeres de Río de Janeiro - RJ, Brasil História Natural de Lesões Precursoras do Câncer do Colo do Útero: Estudo Exploratório de uma Coorte de Mulheres do Rio de Janeiro - RJ, Brasil |
title |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
spellingShingle |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil Silva, Ilce Ferreira da Neoplasias do Colo do Útero/epidemiologia Lesões Pré-Cancerosas Neoplasia Intra-Epitelial Cervical História Natural das Doenças Uterine Cervical Neoplasms/epidemiology Precancerous Conditions Cervical Intraepithelial Neoplasia Natural History of Diseases Neoplasias del Cuello Uterino/epidemiología Lesiones Precancerosas Neoplasia Intraepitelial del Cuello Uterino Historia Natural de las Enfermedades |
title_short |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
title_full |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
title_fullStr |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
title_full_unstemmed |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
title_sort |
Natural History of Precancerous Cervical Lesions: an Exploratory Study of a Cohort of Women from Rio de Janeiro - RJ, Brazil |
author |
Silva, Ilce Ferreira da |
author_facet |
Silva, Ilce Ferreira da Koifman, Rosalina Jorge Koifman, Sergio Mattos, Inês Echenique |
author_role |
author |
author2 |
Koifman, Rosalina Jorge Koifman, Sergio Mattos, Inês Echenique |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Ilce Ferreira da Koifman, Rosalina Jorge Koifman, Sergio Mattos, Inês Echenique |
dc.subject.por.fl_str_mv |
Neoplasias do Colo do Útero/epidemiologia Lesões Pré-Cancerosas Neoplasia Intra-Epitelial Cervical História Natural das Doenças Uterine Cervical Neoplasms/epidemiology Precancerous Conditions Cervical Intraepithelial Neoplasia Natural History of Diseases Neoplasias del Cuello Uterino/epidemiología Lesiones Precancerosas Neoplasia Intraepitelial del Cuello Uterino Historia Natural de las Enfermedades |
topic |
Neoplasias do Colo do Útero/epidemiologia Lesões Pré-Cancerosas Neoplasia Intra-Epitelial Cervical História Natural das Doenças Uterine Cervical Neoplasms/epidemiology Precancerous Conditions Cervical Intraepithelial Neoplasia Natural History of Diseases Neoplasias del Cuello Uterino/epidemiología Lesiones Precancerosas Neoplasia Intraepitelial del Cuello Uterino Historia Natural de las Enfermedades |
description |
Introduction: Cervical Intraepithelial Neoplasia (CIN), when untreated, is likely to progress to cancer, persists as CIN, or regresses to a normal tissue. Objective: To determine the pattern of natural evolution of precancerous lesions of the cervix, and to evaluate the role of co-factors on the risk of cervical cancer development in a cohort of women from Rio de Janeiro, Brazil. Method: An exploratory study was carried out in 227 women with precancerous lesions referred from the Cervical Pathology Center from 1998 to 2000. The evolution of precancerous lesions was ascertained in patients who were left untreated for presenting clinical limitations. Patients were followed for two years, with a cytological exam. Cytological results were classified as follows: Low grade Squamous Intraepithelial Lesion (LSIL), high grade Squamous Intraepithelial Lesion (HSIL). Likelihood and risk of regression, persistence and progression of precancerous lesions were determined using the Kaplan Meier test (L-R:95%) and the Proportional Cox Regression test. Results: The lesion regression likelihood was the following: 46% (LSIL), 72.8% (HSIL). HSIL was more likely to persist (43.1%) and progress to cervical cancer (7.1%) than LSIL. Women <30 years were more likely to regress (79.9%) than older women, and women ≥50 were more likely to show lesion persistence (43.3%) and to progress to cervical cancer (31.8%) than younger women. Conclusion: Women <30 years at diagnosis of LSIL were more likely to regress than older women, and women ≥50 years with HSIL were at higher risk persistence and progression, when compared to younger women. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/587 10.32635/2176-9745.RBC.2012v58n3.587 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/587 |
identifier_str_mv |
10.32635/2176-9745.RBC.2012v58n3.587 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/587/362 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 58 No. 3 (2012): July/Aug./Sept.; 369-378 Revista Brasileira de Cancerologia; Vol. 58 Núm. 3 (2012): jul./ago./sept.; 369-378 Revista Brasileira de Cancerologia; v. 58 n. 3 (2012): jul./ago./set. ; 369-378 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
institution |
INCA |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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