Cleft Lip/Palate and Cancer: a True Connection

Detalhes bibliográficos
Autor(a) principal: Vieira, Alexandre Rezende
Data de Publicação: 2021
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2396
Resumo: Multifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.
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spelling Cleft Lip/Palate and Cancer: a True ConnectionLabio Leporino/Paladar Hendido y Cáncer: una Conexión VerdaderaFissura Labiopalatina e Câncer: uma Conexão VerdadeiraLabio LeporinoFisura del PaladarNeoplasiasCleft LipCleft PalateNeoplasmsLabio LeporinoFisura del PaladarNeoplasiasMultifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.Multifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.INCA2021-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo de opniãoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/239610.32635/2176-9745.RBC.2021v67n4.2396Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-062396Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-062396Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-0623962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/2396/1508Copyright (c) 2021 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVieira, Alexandre Rezende 2022-10-14T19:29:20Zoai:rbc.inca.gov.br:article/2396Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-10-14T19:29:20Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Cleft Lip/Palate and Cancer: a True Connection
Labio Leporino/Paladar Hendido y Cáncer: una Conexión Verdadera
Fissura Labiopalatina e Câncer: uma Conexão Verdadeira
title Cleft Lip/Palate and Cancer: a True Connection
spellingShingle Cleft Lip/Palate and Cancer: a True Connection
Vieira, Alexandre Rezende
Labio Leporino
Fisura del Paladar
Neoplasias
Cleft Lip
Cleft Palate
Neoplasms
Labio Leporino
Fisura del Paladar
Neoplasias
title_short Cleft Lip/Palate and Cancer: a True Connection
title_full Cleft Lip/Palate and Cancer: a True Connection
title_fullStr Cleft Lip/Palate and Cancer: a True Connection
title_full_unstemmed Cleft Lip/Palate and Cancer: a True Connection
title_sort Cleft Lip/Palate and Cancer: a True Connection
author Vieira, Alexandre Rezende
author_facet Vieira, Alexandre Rezende
author_role author
dc.contributor.author.fl_str_mv Vieira, Alexandre Rezende
dc.subject.por.fl_str_mv Labio Leporino
Fisura del Paladar
Neoplasias
Cleft Lip
Cleft Palate
Neoplasms
Labio Leporino
Fisura del Paladar
Neoplasias
topic Labio Leporino
Fisura del Paladar
Neoplasias
Cleft Lip
Cleft Palate
Neoplasms
Labio Leporino
Fisura del Paladar
Neoplasias
description Multifactorial cleft lip and palate is relatively common in populations (1 in every 700 livebirths). Individuals born with clefts require lifelong treatment after initial surgical repair and data suggested that their lifespan is shorter, possibly due to cancer or psychiatric conditions. Molecular defects that alter facial development in utero appear to later in life predispose to cancer. Common polymorphisms in e-cadherin and an endoplasmic reticulum transmembrane sensor gene appear to hold the promise to be biomarkers that may help to define individual risks to cancer, in the presence or not of family history of clefts.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo de opnião
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2396
10.32635/2176-9745.RBC.2021v67n4.2396
url https://rbc.inca.gov.br/index.php/revista/article/view/2396
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n4.2396
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2396/1508
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-062396
Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-062396
Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-062396
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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