Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Revista Brasileira de Cancerologia (Online) |
| Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/33 |
Resumo: | Introduction: Kidney tumors account for about 7% of all childhood malignancies. Synchronous bilateral Wilms tumor corresponds to 5-7% of all nephroblastomas. The treatment consists of preoperative chemotherapy, followed by conservative surgery, postoperative chemotherapy and, when indicated, radiotherapy. Objective: To analyze the type of surgery and the overall survival of patients with synchronous bilateral Wilms tumor. Method: This retrospective cohort study included 18 pediatric patients from the Hospital do Cancer I, from the National Cancer Institute José Alencar Gomes da Silva, in Rio de Janeiro, from January 2000 to december 2017. Survival curves were calculated using the Kaplan-Meier method. Results: The median age at diagnosis was 19 months, and 10 patients were female. It was possible to perform conservative surgery in 62.5% of the kidneys, and in 41.2% (7/17) of patients in both kidneys. The 5-year overall survival according to the type of surgery was 87.5% for conservative surgery and 62.8% for radical nephrectomy (p=0.0001). The 5-year overall survival of the entire cohort was 70.8%. Conclusion: Conservative surgery in pediatric synchronous bilateral Wilms tumor is feasible and can be performed safely in reference centers. |
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Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival Tumor de Wilms bilateral Sincrónico: Evaluación quirúrgica y SobrevidaTumor de Wilms Bilateral Sincrônico: Avaliação Cirúrgica e SobrevidaTumor de Wilms BilateralCriançaAdolescenteNefrectomiaAnálise de SobrevidaWilms Tumor BilateralChildAdolescentNephrectomySurvival AnalysisTumor de Wilms BilateralNiñoAdolescenteNefrectomíaAnálisis de SupervivenciaIntroduction: Kidney tumors account for about 7% of all childhood malignancies. Synchronous bilateral Wilms tumor corresponds to 5-7% of all nephroblastomas. The treatment consists of preoperative chemotherapy, followed by conservative surgery, postoperative chemotherapy and, when indicated, radiotherapy. Objective: To analyze the type of surgery and the overall survival of patients with synchronous bilateral Wilms tumor. Method: This retrospective cohort study included 18 pediatric patients from the Hospital do Cancer I, from the National Cancer Institute José Alencar Gomes da Silva, in Rio de Janeiro, from January 2000 to december 2017. Survival curves were calculated using the Kaplan-Meier method. Results: The median age at diagnosis was 19 months, and 10 patients were female. It was possible to perform conservative surgery in 62.5% of the kidneys, and in 41.2% (7/17) of patients in both kidneys. The 5-year overall survival according to the type of surgery was 87.5% for conservative surgery and 62.8% for radical nephrectomy (p=0.0001). The 5-year overall survival of the entire cohort was 70.8%. Conclusion: Conservative surgery in pediatric synchronous bilateral Wilms tumor is feasible and can be performed safely in reference centers. Introducción: Los tumores renales representan alrededor del 7% de todas las neoplasias malignas de la infancia. El tumor de Wilms bilateral sincrónico corresponde al 5-7% de todos los nefroblastomas. El tratamiento consiste en quimioterapia preoperatoria, seguida de cirugía conservadora, quimioterapia postoperatoria y, cuando indicada, la radioterapia. Objetivo: Analizar el tipo de cirugía y la supervivencia global de los pacientes con un tumor de Wilms bilateral sincrónico. Método: Este estudio de cohorte retrospectivo incluyó 18 pacientes pediátricos del Hospital del Cáncer I, del Instituto Nacional de Cáncer José Alencar Gomes da Silva, nel Río de Janeiro, de enero de 2000 a diciembre de 2017. las curvas de sobrevida fueron calculadas por el método Kaplan-Meier. Resultados: La edad media al diagnóstico fue de 19 meses, siendo diez casos del sexo femenino. en el 62,5% de los riñones operados fue posible realizar cirugía conservadora, siendo en el 41,2% (7/17) de los pacientes en los dos riñones. la supervivencia global en cinco años según el tipo de cirugía fue de 87,5% para cirugía conservadora y de 62,8% nefrectomía total (p=0,0001). La supervivencia global en cinco años para la cohorte entera fue del 70,8%. Conclusión: La cirugía conservadora en niños con el tumor de Wilms bilateral sincrónico es viable y puede ser realizada con seguridad en centros de referencia. Introdução: Os tumores renais representam cerca de 7% de todas as neoplasias malignas da infância. O tumor de Wilms bilateral sincrônico corresponde a 5-7% de todos os nefroblastomas. O tratamento consiste em quimioterapia pré-operatória, seguida de cirurgia conservadora, quimioterapia pós-operatória e, quando indicada, radioterapia. Objetivo: Analisar o tipo de cirurgia e a sobrevida global dos pacientes com tumor de Wilms bilateral sincrônico. Método: Este estudo de coorte retrospectivo incluiu 18 pacientes pediátricos do Hospital do Câncer I, do Instituto Nacional de Câncer José Alencar Gomes da Silva, no Rio de Janeiro, de janeiro de 2000 a dezembro de 2017. Curvas de sobrevida foram calculadas pelo método Kaplan-Meier. Resultados: A idade mediana ao diagnóstico foi de 19 meses, sendo dez casos do sexo feminino. Em 62,5% dos rins operados, foi possível realizar cirurgia conservadora e, em 41,2% (7/17) dos pacientes, em ambos os rins. A sobrevida global em cinco anos, segundo o tipo cirurgia, foi de 87,5% para cirurgia conservadora e de 62,8% para nefrectomia total (p=0,0001). A sobrevida global em cinco anos para a coorte inteira foi de 70,8%. Conclusão: A cirurgia preservadora de tecido renal em crianças com o tumor de Wilms bilateral sincrônico é viável e pode ser realizada com segurança em centros de referência.INCA2018-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/3310.32635/2176-9745.RBC.2018v64n3.33Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 333-339Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 333-339Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 333-3392176-974510.32635/2176-9745.RBC.2018v64n3reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/33/9https://rbc.inca.gov.br/index.php/revista/article/view/33/192Baptista Oliveira, PabloFornaciari Grabois, MariliaFerreira da Silva Lima, FernandaSilvestre de Faria, Paulo Antôniodo Nascimento Santos, VanessaAlbuquerque Girão Gutierrez, Francisca NormaFerman, Sima EstherVianna de Carvalho, Ricardoinfo:eu-repo/semantics/openAccess2021-11-29T20:06:12Zoai:rbc.inca.gov.br:article/33Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:06:12Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
| dc.title.none.fl_str_mv |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival Tumor de Wilms bilateral Sincrónico: Evaluación quirúrgica y Sobrevida Tumor de Wilms Bilateral Sincrônico: Avaliação Cirúrgica e Sobrevida |
| title |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| spellingShingle |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival Baptista Oliveira, Pablo Tumor de Wilms Bilateral Criança Adolescente Nefrectomia Análise de Sobrevida Wilms Tumor Bilateral Child Adolescent Nephrectomy Survival Analysis Tumor de Wilms Bilateral Niño Adolescente Nefrectomía Análisis de Supervivencia |
| title_short |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| title_full |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| title_fullStr |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| title_full_unstemmed |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| title_sort |
Synchronous Bilateral Wilms Tumor: Surgical Evaluation and Survival |
| author |
Baptista Oliveira, Pablo |
| author_facet |
Baptista Oliveira, Pablo Fornaciari Grabois, Marilia Ferreira da Silva Lima, Fernanda Silvestre de Faria, Paulo Antônio do Nascimento Santos, Vanessa Albuquerque Girão Gutierrez, Francisca Norma Ferman, Sima Esther Vianna de Carvalho, Ricardo |
| author_role |
author |
| author2 |
Fornaciari Grabois, Marilia Ferreira da Silva Lima, Fernanda Silvestre de Faria, Paulo Antônio do Nascimento Santos, Vanessa Albuquerque Girão Gutierrez, Francisca Norma Ferman, Sima Esther Vianna de Carvalho, Ricardo |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Baptista Oliveira, Pablo Fornaciari Grabois, Marilia Ferreira da Silva Lima, Fernanda Silvestre de Faria, Paulo Antônio do Nascimento Santos, Vanessa Albuquerque Girão Gutierrez, Francisca Norma Ferman, Sima Esther Vianna de Carvalho, Ricardo |
| dc.subject.por.fl_str_mv |
Tumor de Wilms Bilateral Criança Adolescente Nefrectomia Análise de Sobrevida Wilms Tumor Bilateral Child Adolescent Nephrectomy Survival Analysis Tumor de Wilms Bilateral Niño Adolescente Nefrectomía Análisis de Supervivencia |
| topic |
Tumor de Wilms Bilateral Criança Adolescente Nefrectomia Análise de Sobrevida Wilms Tumor Bilateral Child Adolescent Nephrectomy Survival Analysis Tumor de Wilms Bilateral Niño Adolescente Nefrectomía Análisis de Supervivencia |
| description |
Introduction: Kidney tumors account for about 7% of all childhood malignancies. Synchronous bilateral Wilms tumor corresponds to 5-7% of all nephroblastomas. The treatment consists of preoperative chemotherapy, followed by conservative surgery, postoperative chemotherapy and, when indicated, radiotherapy. Objective: To analyze the type of surgery and the overall survival of patients with synchronous bilateral Wilms tumor. Method: This retrospective cohort study included 18 pediatric patients from the Hospital do Cancer I, from the National Cancer Institute José Alencar Gomes da Silva, in Rio de Janeiro, from January 2000 to december 2017. Survival curves were calculated using the Kaplan-Meier method. Results: The median age at diagnosis was 19 months, and 10 patients were female. It was possible to perform conservative surgery in 62.5% of the kidneys, and in 41.2% (7/17) of patients in both kidneys. The 5-year overall survival according to the type of surgery was 87.5% for conservative surgery and 62.8% for radical nephrectomy (p=0.0001). The 5-year overall survival of the entire cohort was 70.8%. Conclusion: Conservative surgery in pediatric synchronous bilateral Wilms tumor is feasible and can be performed safely in reference centers. |
| publishDate |
2018 |
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2018-09-28 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
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article |
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publishedVersion |
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https://rbc.inca.gov.br/index.php/revista/article/view/33 10.32635/2176-9745.RBC.2018v64n3.33 |
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https://rbc.inca.gov.br/index.php/revista/article/view/33 |
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10.32635/2176-9745.RBC.2018v64n3.33 |
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por eng |
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por eng |
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https://rbc.inca.gov.br/index.php/revista/article/view/33/9 https://rbc.inca.gov.br/index.php/revista/article/view/33/192 |
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openAccess |
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application/pdf application/pdf |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 333-339 Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 333-339 Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 333-339 2176-9745 10.32635/2176-9745.RBC.2018v64n3 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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Revista Brasileira de Cancerologia (Online) |
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