Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location

Detalhes bibliográficos
Autor(a) principal: Guerra, Eliete Neves da Silva
Data de Publicação: 2005
Outros Autores: Paula, Élbio C., Oliveira, José Carlos de, Pinto Júnior, Décio S., Araújo, Vera C., Araújo, Ney S.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1990
Resumo: Objective: To correlate the expression of cyclin D1, an oncogene, and p16, a tumor suppressor gene to the clinicopathological features of oral squamous cell carcinoma (OSCC). Methods: Formalin-fixed and paraffinembedded samples from 34 patients with primary oral squamous cell carcinoma (OSCC) were retrieved from the files of the Araújo Jorge Hospital from Goiânia, Brazil. Features such as TMN classification and anatomical site, were obtained from the patients' records. The immunohistochemistry technique was realized in the Oral Pathology Department, School of Dentistry, University of São Paulo, Brazil. Results and Conclusions: There was no correlation in the mean number of cyclin D1 positive nuclei and p16 with the clinicopathological features. Therefore, cyclin D1 was less expressed in OSCC of lower lips, and in T1 tumors. The results indicated that nuclear accumulation of p16 was not found to be of prognostic significance. The findings of cyclin D1 expression doesn't show an absolute prognostic marker that is also evidence from the p values. However, they suggest that higher level of cyclin D1 expression contributes, together with other activated oncongene, in the process of tumor progression.
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spelling Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and locationExpressão imunoistoquímica da ciclina D1 e do p16 em carcinoma epidermóide de boca: correlação com sistema TNM e localizaçãoCarcinoma EpidermóideBocaImunoistoquímicaCiclina D1p16Squamous cell carcinomaMouthImmunohistochemicalCyclin D1p16Objective: To correlate the expression of cyclin D1, an oncogene, and p16, a tumor suppressor gene to the clinicopathological features of oral squamous cell carcinoma (OSCC). Methods: Formalin-fixed and paraffinembedded samples from 34 patients with primary oral squamous cell carcinoma (OSCC) were retrieved from the files of the Araújo Jorge Hospital from Goiânia, Brazil. Features such as TMN classification and anatomical site, were obtained from the patients' records. The immunohistochemistry technique was realized in the Oral Pathology Department, School of Dentistry, University of São Paulo, Brazil. Results and Conclusions: There was no correlation in the mean number of cyclin D1 positive nuclei and p16 with the clinicopathological features. Therefore, cyclin D1 was less expressed in OSCC of lower lips, and in T1 tumors. The results indicated that nuclear accumulation of p16 was not found to be of prognostic significance. The findings of cyclin D1 expression doesn't show an absolute prognostic marker that is also evidence from the p values. However, they suggest that higher level of cyclin D1 expression contributes, together with other activated oncongene, in the process of tumor progression.Objetivo: Avaliar a expressão imunoistoquímica da ciclina D1 e do p16 (proteínas envolvidas nas vias de proliferação celular e utilizadas para determinar o prognóstico de neoplasias malignas) em carcinoma epidermóide de boca. Correlacionar a imunomarcação com o sistema TNM (Tamanho do tumor, presença de linfonodo metastático e metástase à distância) e com sua localização anatômica. Métodos: Trinta e quatro (34) blocos de parafina contendo fragmentos de biópsia incisional de carcinomas epidermóides bucais primários foram obtidos no Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás. Os dados dos pacientes quanto à localização anatômica e o Sistema TNM foram coletados dos prontuários. A expressão das proteínas ciclina D1 e p16 foi verificada através da técnica imunoistoquímica utilizando a Streptoavidina-Biotina no Laboratório de Patologia Bucal da Faculdade de Odontologia da Universidade de São Paulo (FOUSP). Resultados e Conclusões: Os resultados não revelaram diferença estatisticamente significativa entre o número médio de núcleos positivos para a ciclina D1 e os dados clínicos dos pacientes. Porém, uma menor porcentagem de marcação nos carcinomas de lábio inferior e menor expressão nos tumores classificados clinicamente como T1 foi encontrada. Não houve diferença estatisticamente significativa entre o número médio de núcleos p16 positivos e os dados clínicos dos pacientes com carcinoma epidermóide de boca. Pode-se sugerir que houve um acúmulo nuclear de p16, mas este resultado não tem significância no prognóstico. Entretanto, os resultados da ciclina D1 não mostraram que ela é um marcador absoluto de prognóstico, mas sugerem que o aumento do nível de ciclina D1 contribui junto com outros oncogenes no processo de progressão tumoral.INCA2005-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/199010.32635/2176-9745.RBC.2005v51n1.1990Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 31-37Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 31-37Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 31-372176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1990/1215Guerra, Eliete Neves da Silva Paula, Élbio C. Oliveira, José Carlos de Pinto Júnior, Décio S. Araújo, Vera C. Araújo, Ney S. info:eu-repo/semantics/openAccess2021-11-29T20:31:12Zoai:rbc.inca.gov.br:article/1990Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:31:12Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
Expressão imunoistoquímica da ciclina D1 e do p16 em carcinoma epidermóide de boca: correlação com sistema TNM e localização
title Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
spellingShingle Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
Guerra, Eliete Neves da Silva
Carcinoma Epidermóide
Boca
Imunoistoquímica
Ciclina D1
p16
Squamous cell carcinoma
Mouth
Immunohistochemical
Cyclin D1
p16
title_short Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
title_full Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
title_fullStr Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
title_full_unstemmed Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
title_sort Cyclin D1 and p16 immunohistochemical expression in oral squamous cell carcinoma: correlation with TMN classification and location
author Guerra, Eliete Neves da Silva
author_facet Guerra, Eliete Neves da Silva
Paula, Élbio C.
Oliveira, José Carlos de
Pinto Júnior, Décio S.
Araújo, Vera C.
Araújo, Ney S.
author_role author
author2 Paula, Élbio C.
Oliveira, José Carlos de
Pinto Júnior, Décio S.
Araújo, Vera C.
Araújo, Ney S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guerra, Eliete Neves da Silva
Paula, Élbio C.
Oliveira, José Carlos de
Pinto Júnior, Décio S.
Araújo, Vera C.
Araújo, Ney S.
dc.subject.por.fl_str_mv Carcinoma Epidermóide
Boca
Imunoistoquímica
Ciclina D1
p16
Squamous cell carcinoma
Mouth
Immunohistochemical
Cyclin D1
p16
topic Carcinoma Epidermóide
Boca
Imunoistoquímica
Ciclina D1
p16
Squamous cell carcinoma
Mouth
Immunohistochemical
Cyclin D1
p16
description Objective: To correlate the expression of cyclin D1, an oncogene, and p16, a tumor suppressor gene to the clinicopathological features of oral squamous cell carcinoma (OSCC). Methods: Formalin-fixed and paraffinembedded samples from 34 patients with primary oral squamous cell carcinoma (OSCC) were retrieved from the files of the Araújo Jorge Hospital from Goiânia, Brazil. Features such as TMN classification and anatomical site, were obtained from the patients' records. The immunohistochemistry technique was realized in the Oral Pathology Department, School of Dentistry, University of São Paulo, Brazil. Results and Conclusions: There was no correlation in the mean number of cyclin D1 positive nuclei and p16 with the clinicopathological features. Therefore, cyclin D1 was less expressed in OSCC of lower lips, and in T1 tumors. The results indicated that nuclear accumulation of p16 was not found to be of prognostic significance. The findings of cyclin D1 expression doesn't show an absolute prognostic marker that is also evidence from the p values. However, they suggest that higher level of cyclin D1 expression contributes, together with other activated oncongene, in the process of tumor progression.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1990
10.32635/2176-9745.RBC.2005v51n1.1990
url https://rbc.inca.gov.br/index.php/revista/article/view/1990
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n1.1990
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1990/1215
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 1 (2005): Jan./Feb./Mar.; 31-37
Revista Brasileira de Cancerologia; Vol. 51 Núm. 1 (2005): ene./feb./mar.; 31-37
Revista Brasileira de Cancerologia; v. 51 n. 1 (2005): jan./fev./mar.; 31-37
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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