Differential MicroRNAs Expression in Prostate Cancer

Detalhes bibliográficos
Autor(a) principal: Delella, Flávia Karina
Data de Publicação: 2012
Outros Autores: Moroz, Andrei, Carvalho, Robson Francisco, Felisbino, Sérgio Luis
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/580
Resumo: Introduction: MicroRNAs are small non-coding RNAs that act as post-transcriptional regulators of mRNA targets. Recent studies suggest that differential expression of some microRNA s are associated with cancer development, invasion and metastasis, including prostate cancer. Improvements in detection techniques and findings of new molecular markers are important tools for early diagnosis and treatment of individual patients. Objective: To carry out a scientific review about the main microRNAs altered in prostate cancer. Methods: The PubMed database was chosen for the research using the key words microRNA and prostate cancer. The discovery and study of microRNAs involved in cancer progression are recent scientific topics and, within the 260 publications found, 25 were selected for this review. Results: Many microRNAs are classified as promoters of cell survival and tumor growth. The papers selected for this review describe differential expression of microRNAs in samples of prostate tumors and prostatic tumor cells studied in vitro. Alterations of microRNAs in plasma, urine and tumor tissue were found to be interesting tools to distinguish patients with prostate cancer from healthy individuals, classifying these molecules as promising biomarkers. Conclusion: The excellent quality of publications highlights the importance of post-transcriptional regulation exerted by microRNAs in prostate cancer progression. Despite being a recent topic, modern molecular techniques are being employed to unveil novel microRNAs and to characterize their mechanisms of action.
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spelling Differential MicroRNAs Expression in Prostate CancerExpresión Diferencial de MicroARNs en Cáncer de PróstataExpressão Diferencial de MicroRNAs no Câncer de PróstataNeoplasias da PróstataMicroRNA sExpressão GênicaProstatic NeoplasmsMicroRNAsGene ExpressionNeoplasias de la PróstataMicroRNAsExpresión GénicaIntroduction: MicroRNAs are small non-coding RNAs that act as post-transcriptional regulators of mRNA targets. Recent studies suggest that differential expression of some microRNA s are associated with cancer development, invasion and metastasis, including prostate cancer. Improvements in detection techniques and findings of new molecular markers are important tools for early diagnosis and treatment of individual patients. Objective: To carry out a scientific review about the main microRNAs altered in prostate cancer. Methods: The PubMed database was chosen for the research using the key words microRNA and prostate cancer. The discovery and study of microRNAs involved in cancer progression are recent scientific topics and, within the 260 publications found, 25 were selected for this review. Results: Many microRNAs are classified as promoters of cell survival and tumor growth. The papers selected for this review describe differential expression of microRNAs in samples of prostate tumors and prostatic tumor cells studied in vitro. Alterations of microRNAs in plasma, urine and tumor tissue were found to be interesting tools to distinguish patients with prostate cancer from healthy individuals, classifying these molecules as promising biomarkers. Conclusion: The excellent quality of publications highlights the importance of post-transcriptional regulation exerted by microRNAs in prostate cancer progression. Despite being a recent topic, modern molecular techniques are being employed to unveil novel microRNAs and to characterize their mechanisms of action.Introducción: Los MicroARN s son pequenos ARNs no codificantes que actúan como reguladores post-transcripcionales de ARNs mensajeros blancos. Estudios recientes demostraron que la expresión diferencial de algunos MicroARNs está asociada con el desarrollo, invasión y metástasis de varios tipos de cánceres, entre ellos el cáncer de próstata. Los avances en las técnicas de detección y hallazgo de nuevos marcadores moleculares son herramientas importantes para el diagnostico precoz y tratamiento individualizado de los pacientes. Objetivo: Realizar revisión científica sobre los principales MicroARNs alterados en el cáncer de próstata. Método: La base de datos PubMed fue elegida para el estudio y las palabras claves utilizadas han sido MicroARNs y cáncer de próstata. El descubrimiento y el estudio de los MicroARNs involucrados en la progresión del cáncer son temas científicos recientes, y de las 260 publicaciones encontradas, se seleccionaron 25 para esta la revisión. Resultados: Muchos MicroARN s son clasificados como promotores de la supervivencia celular y del crecimiento tumoral. Los trabajos seleccionados describen una expresión distinta de MicroARNs en muestras de tumores de próstata y en células tumorales de la próstata estudiadas in vitro. La alteración de los niveles de expresión de los microRNAs en plasma, orina y en los tejidos tumorales, resultó ser una interesante herramienta para distinguir a los pacientes con cáncer de próstata de pacientes sanos, lo cual clasifica estas moléculas como biomarcadores prometedores. Conclusión: La excelente calidad de las publicaciones destaca la importancia de la regulación post transcripcional ejercida por los MicroARNs en la progresión del cáncer de próstata. A pesar de ser un tema reciente, las técnicas moleculares de última generación se están empleando en el hallazgo de nuevos MicroARNs y para la caracterización de la función de aquellos que ya existen.  Introdução: MicroRNAs são pequenos RNAs não codificantes, que atuam como reguladores pós-transcricionais de RNAs mensageiros-alvo. Estudos recentes demonstram que a expressão diferencial de alguns microRNAs associa-se com o desenvolvimento, invasão e metástase de vários tipos de câncer, incluindo o câncer de próstata. Os avanços nas técnicas de detecção e descoberta de novos marcadores moleculares são ferramentas importantes para o diagnóstico precoce e tratamento individual dos pacientes. Objetivo: Realizar revisão científica sobre os principais microRNAs alterados no câncer de próstata. Método: O PubMed foi a base de dados escolhida para a pesquisa e as palavras-chave utilizadas foram microRNA e câncer de próstata. A descoberta e o estudo dos microRNAs envolvidos na progressão do câncer são temas científicos recentes e, das 260 publicações encontradas, 25 foram selecionadas para compor esta revisão. Resultados: Muitos microRNAs são classificados como promotores da sobrevivência celular e do cresci mento tumoral. Os trabalhos selecionados para esta revisão descrevem expressão diferenciada de microRNAs em amostras de tumores prostáticos e em células tumorais prostáticas estudadas in vitro. A alteração de microRNAs no plasma, na urina e no tecido tumoral mostrou-se uma ferramenta interessante para distinguir pacientes com cancer de próstata de pacientes saudáveis, classificando essas moléculas como biomarcadores promissores. Conclusão: A excelente qualidade das publicações evidencia a importância da regulação pós-transcricional exercida pelos microRNAs na progressão do câncer de próstata. Apesar de o tema ser recente, técnicas moleculares de ultima geração estão sendo empregadas para a descoberta de novos microRNAs e para a caracterização da função daqueles já existentes.  INCA2012-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/58010.32635/2176-9745.RBC.2012v58n4.580Revista Brasileira de Cancerologia; Vol. 58 No. 4 (2012): Oct./Nov./Dec.; 687-693Revista Brasileira de Cancerologia; Vol. 58 Núm. 4 (2012): oct./nov./dic.; 687-693Revista Brasileira de Cancerologia; v. 58 n. 4 (2012): out./nov./dez. ; 687-6932176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/580/357Delella, Flávia Karina Moroz, Andrei Carvalho, Robson Francisco Felisbino, Sérgio Luis info:eu-repo/semantics/openAccess2021-11-29T20:12:56Zoai:rbc.inca.gov.br:article/580Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:12:56Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Differential MicroRNAs Expression in Prostate Cancer
Expresión Diferencial de MicroARNs en Cáncer de Próstata
Expressão Diferencial de MicroRNAs no Câncer de Próstata
title Differential MicroRNAs Expression in Prostate Cancer
spellingShingle Differential MicroRNAs Expression in Prostate Cancer
Delella, Flávia Karina
Neoplasias da Próstata
MicroRNA s
Expressão Gênica
Prostatic Neoplasms
MicroRNAs
Gene Expression
Neoplasias de la Próstata
MicroRNAs
Expresión Génica
title_short Differential MicroRNAs Expression in Prostate Cancer
title_full Differential MicroRNAs Expression in Prostate Cancer
title_fullStr Differential MicroRNAs Expression in Prostate Cancer
title_full_unstemmed Differential MicroRNAs Expression in Prostate Cancer
title_sort Differential MicroRNAs Expression in Prostate Cancer
author Delella, Flávia Karina
author_facet Delella, Flávia Karina
Moroz, Andrei
Carvalho, Robson Francisco
Felisbino, Sérgio Luis
author_role author
author2 Moroz, Andrei
Carvalho, Robson Francisco
Felisbino, Sérgio Luis
author2_role author
author
author
dc.contributor.author.fl_str_mv Delella, Flávia Karina
Moroz, Andrei
Carvalho, Robson Francisco
Felisbino, Sérgio Luis
dc.subject.por.fl_str_mv Neoplasias da Próstata
MicroRNA s
Expressão Gênica
Prostatic Neoplasms
MicroRNAs
Gene Expression
Neoplasias de la Próstata
MicroRNAs
Expresión Génica
topic Neoplasias da Próstata
MicroRNA s
Expressão Gênica
Prostatic Neoplasms
MicroRNAs
Gene Expression
Neoplasias de la Próstata
MicroRNAs
Expresión Génica
description Introduction: MicroRNAs are small non-coding RNAs that act as post-transcriptional regulators of mRNA targets. Recent studies suggest that differential expression of some microRNA s are associated with cancer development, invasion and metastasis, including prostate cancer. Improvements in detection techniques and findings of new molecular markers are important tools for early diagnosis and treatment of individual patients. Objective: To carry out a scientific review about the main microRNAs altered in prostate cancer. Methods: The PubMed database was chosen for the research using the key words microRNA and prostate cancer. The discovery and study of microRNAs involved in cancer progression are recent scientific topics and, within the 260 publications found, 25 were selected for this review. Results: Many microRNAs are classified as promoters of cell survival and tumor growth. The papers selected for this review describe differential expression of microRNAs in samples of prostate tumors and prostatic tumor cells studied in vitro. Alterations of microRNAs in plasma, urine and tumor tissue were found to be interesting tools to distinguish patients with prostate cancer from healthy individuals, classifying these molecules as promising biomarkers. Conclusion: The excellent quality of publications highlights the importance of post-transcriptional regulation exerted by microRNAs in prostate cancer progression. Despite being a recent topic, modern molecular techniques are being employed to unveil novel microRNAs and to characterize their mechanisms of action.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/580
10.32635/2176-9745.RBC.2012v58n4.580
url https://rbc.inca.gov.br/index.php/revista/article/view/580
identifier_str_mv 10.32635/2176-9745.RBC.2012v58n4.580
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/580/357
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 58 No. 4 (2012): Oct./Nov./Dec.; 687-693
Revista Brasileira de Cancerologia; Vol. 58 Núm. 4 (2012): oct./nov./dic.; 687-693
Revista Brasileira de Cancerologia; v. 58 n. 4 (2012): out./nov./dez. ; 687-693
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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