Association of Epstein-Barr virus (EBV) with Solid Tumors

Detalhes bibliográficos
Autor(a) principal: Lima, Marcos Antonio Pereira de
Data de Publicação: 2006
Outros Autores: Rabenhorst, Silvia Helena Barem
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1912
Resumo: The gamma-herpes Epstein-Barr virus (EBV) is a ubiquitous viral agent that causes persistent infection in more than 90% of the world adult population. EBV is associated with several lymphoproliferative disorders such as infectious mononucleosis, Burkitt's lymphoma, Hodgkin's disease, and post-transplant lymphoproliferative disease. The oncogenic role of EBV in tumors of lymphoid origin has been widely investigated. With respect to solid tumors, the role of EBV is well documented in nasopharyngeal carcinoma. However, new findings have shown that the spectrum of cellular infection of EBV is broader, having been detected in cells from other kinds of solid tumors, thus indicating its involvement in tumorigenesis of these tumors. The current article begins with a brief description of EBV biology and aims to provide a summary of new findings concerning the association between EBV and solid tumors, highlighting evidence of the viral role and characteristics of infections in each tissue.
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spelling Association of Epstein-Barr virus (EBV) with Solid TumorsAssociação do vírus Epstein-Barr (EBV) com tumores sólidosVírus de Epstein-BarrTumores sólidosOncogêneseEpstein-Barr virusSolid tumorsOncogenesisThe gamma-herpes Epstein-Barr virus (EBV) is a ubiquitous viral agent that causes persistent infection in more than 90% of the world adult population. EBV is associated with several lymphoproliferative disorders such as infectious mononucleosis, Burkitt's lymphoma, Hodgkin's disease, and post-transplant lymphoproliferative disease. The oncogenic role of EBV in tumors of lymphoid origin has been widely investigated. With respect to solid tumors, the role of EBV is well documented in nasopharyngeal carcinoma. However, new findings have shown that the spectrum of cellular infection of EBV is broader, having been detected in cells from other kinds of solid tumors, thus indicating its involvement in tumorigenesis of these tumors. The current article begins with a brief description of EBV biology and aims to provide a summary of new findings concerning the association between EBV and solid tumors, highlighting evidence of the viral role and characteristics of infections in each tissue.O gama-herpes vírus Epstein-Barr (EBV) é um vírus ubíquo, que estabelece infecção persistente em mais de 90% da população mundial adulta. O EBV está associado a várias desordens proliferativas benignas e malignas de origem linfóide, tais como mononucleose infecciosa, linfoma de Burkitt, doença de Hodgkin e doença linfoproliferativa póstransplante, nas quais o seu papel oncogênico tem sido largamente estudado. Em tumores sólidos, a relação do EBV é bem documentada em carcinomas de nasofaringe. Contudo, novos achados têm demonstrado que o EBV apresenta um espectro de infecção celular mais amplo do que se conhecia, sendo detectado em células de outros tipos de tumores sólidos, com evidências que apontam para a sua participação na tumorigênese dessas neoplasias. O presente artigo inicia com uma breve descrição da biologia do EBV e tem como objetivo realizar uma compilação dos achados encontrados na literatura, concernentes à associação do EBV a neoplasias sólidas, apontando as evidências do envolvimento viral e as características das infecções que são encontradas em cada tecido.INCA2006-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/191210.32635/2176-9745.RBC.2006v52n1.1912Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 87-96Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 87-96Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 87-962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1912/1163Lima, Marcos Antonio Pereira deRabenhorst, Silvia Helena Bareminfo:eu-repo/semantics/openAccess2021-11-29T20:28:30Zoai:rbc.inca.gov.br:article/1912Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:28:30Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Association of Epstein-Barr virus (EBV) with Solid Tumors
Associação do vírus Epstein-Barr (EBV) com tumores sólidos
title Association of Epstein-Barr virus (EBV) with Solid Tumors
spellingShingle Association of Epstein-Barr virus (EBV) with Solid Tumors
Lima, Marcos Antonio Pereira de
Vírus de Epstein-Barr
Tumores sólidos
Oncogênese
Epstein-Barr virus
Solid tumors
Oncogenesis
title_short Association of Epstein-Barr virus (EBV) with Solid Tumors
title_full Association of Epstein-Barr virus (EBV) with Solid Tumors
title_fullStr Association of Epstein-Barr virus (EBV) with Solid Tumors
title_full_unstemmed Association of Epstein-Barr virus (EBV) with Solid Tumors
title_sort Association of Epstein-Barr virus (EBV) with Solid Tumors
author Lima, Marcos Antonio Pereira de
author_facet Lima, Marcos Antonio Pereira de
Rabenhorst, Silvia Helena Barem
author_role author
author2 Rabenhorst, Silvia Helena Barem
author2_role author
dc.contributor.author.fl_str_mv Lima, Marcos Antonio Pereira de
Rabenhorst, Silvia Helena Barem
dc.subject.por.fl_str_mv Vírus de Epstein-Barr
Tumores sólidos
Oncogênese
Epstein-Barr virus
Solid tumors
Oncogenesis
topic Vírus de Epstein-Barr
Tumores sólidos
Oncogênese
Epstein-Barr virus
Solid tumors
Oncogenesis
description The gamma-herpes Epstein-Barr virus (EBV) is a ubiquitous viral agent that causes persistent infection in more than 90% of the world adult population. EBV is associated with several lymphoproliferative disorders such as infectious mononucleosis, Burkitt's lymphoma, Hodgkin's disease, and post-transplant lymphoproliferative disease. The oncogenic role of EBV in tumors of lymphoid origin has been widely investigated. With respect to solid tumors, the role of EBV is well documented in nasopharyngeal carcinoma. However, new findings have shown that the spectrum of cellular infection of EBV is broader, having been detected in cells from other kinds of solid tumors, thus indicating its involvement in tumorigenesis of these tumors. The current article begins with a brief description of EBV biology and aims to provide a summary of new findings concerning the association between EBV and solid tumors, highlighting evidence of the viral role and characteristics of infections in each tissue.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1912
10.32635/2176-9745.RBC.2006v52n1.1912
url https://rbc.inca.gov.br/index.php/revista/article/view/1912
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n1.1912
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1912/1163
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 87-96
Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 87-96
Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 87-96
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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