Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1947 |
Resumo: | Apoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior. |
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Assesment of apoptosis in breast cancer: association with histological grade and prognostic factorsAvaliação da apoptose no carcinoma ductal infiltrante da mama: associação com graus histológicos e fatores prognósticosNeoplasias mamáriasCarcinoma de ductos infiltranteApoptoseEstadiamento de neoplasiasBreast neoplasmsInfiltrating duct carcinomaApoptosisNeoplasm stagingPrognosisApoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior.A apoptose é um importante fator no crescimento do câncer de mama, tendo sido associada à progressão tumoral. Neste estudo, a presença de células apoptóticas em carcinoma ductal infiltrante (CDI) graus histológicos I, II e III foi investigada e comparada com outros fatores prognósticos do câncer de mama. A detecção in situ da apoptose em células tumorais foi investigada pelo método TUNEL (Terminaldeoxynucleotidyl-transferase-mediated dUTPFITC nick end-labeling). A proliferação celular, receptores hormonais, c-erbB-2 e p53 foram analisados utilizando-se procedimento imunoistoquímico. Nossos dados demonstraram que alto índice apoptótico está associado a maiores níveis de proliferação, à expressão aumentada de p53, a tumores pouco diferenciados e a negatividade para receptores hormonais. Estes achados indicam que em carcinomas ductais da mama o número de células em apoptose está diretamente associado à progressão histológica e de outros fatores de mal prognósticos, influenciando no comportamento biológico desses tumores.INCA2005-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/194710.32635/2176-9745.RBC.2005v51n3.1947Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 209-218Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 209-218Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 209-2182176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1947/1181Farias, Rogério EstevamSouza, Andrezza RodriguesAarestrup, Fernando Monteiroinfo:eu-repo/semantics/openAccess2021-11-29T20:30:04Zoai:rbc.inca.gov.br:article/1947Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:30:04Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors Avaliação da apoptose no carcinoma ductal infiltrante da mama: associação com graus histológicos e fatores prognósticos |
title |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
spellingShingle |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors Farias, Rogério Estevam Neoplasias mamárias Carcinoma de ductos infiltrante Apoptose Estadiamento de neoplasias Breast neoplasms Infiltrating duct carcinoma Apoptosis Neoplasm staging Prognosis |
title_short |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
title_full |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
title_fullStr |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
title_full_unstemmed |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
title_sort |
Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors |
author |
Farias, Rogério Estevam |
author_facet |
Farias, Rogério Estevam Souza, Andrezza Rodrigues Aarestrup, Fernando Monteiro |
author_role |
author |
author2 |
Souza, Andrezza Rodrigues Aarestrup, Fernando Monteiro |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Farias, Rogério Estevam Souza, Andrezza Rodrigues Aarestrup, Fernando Monteiro |
dc.subject.por.fl_str_mv |
Neoplasias mamárias Carcinoma de ductos infiltrante Apoptose Estadiamento de neoplasias Breast neoplasms Infiltrating duct carcinoma Apoptosis Neoplasm staging Prognosis |
topic |
Neoplasias mamárias Carcinoma de ductos infiltrante Apoptose Estadiamento de neoplasias Breast neoplasms Infiltrating duct carcinoma Apoptosis Neoplasm staging Prognosis |
description |
Apoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1947 10.32635/2176-9745.RBC.2005v51n3.1947 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1947 |
identifier_str_mv |
10.32635/2176-9745.RBC.2005v51n3.1947 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1947/1181 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 209-218 Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 209-218 Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 209-218 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
_version_ |
1797042248848769024 |