Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors

Detalhes bibliográficos
Autor(a) principal: Farias, Rogério Estevam
Data de Publicação: 2005
Outros Autores: Souza, Andrezza Rodrigues, Aarestrup, Fernando Monteiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1947
Resumo: Apoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior.
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spelling Assesment of apoptosis in breast cancer: association with histological grade and prognostic factorsAvaliação da apoptose no carcinoma ductal infiltrante da mama: associação com graus histológicos e fatores prognósticosNeoplasias mamáriasCarcinoma de ductos infiltranteApoptoseEstadiamento de neoplasiasBreast neoplasmsInfiltrating duct carcinomaApoptosisNeoplasm stagingPrognosisApoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior.A apoptose é um importante fator no crescimento do câncer de mama, tendo sido associada à progressão tumoral. Neste estudo, a presença de células apoptóticas em carcinoma ductal infiltrante (CDI) graus histológicos I, II e III foi investigada e comparada com outros fatores prognósticos do câncer de mama. A detecção in situ da apoptose em células tumorais foi investigada pelo método TUNEL (Terminaldeoxynucleotidyl-transferase-mediated dUTPFITC nick end-labeling). A proliferação celular, receptores hormonais, c-erbB-2 e p53 foram analisados utilizando-se procedimento imunoistoquímico. Nossos dados demonstraram que alto índice apoptótico está associado a maiores níveis de proliferação, à expressão aumentada de p53, a tumores pouco diferenciados e a negatividade para receptores hormonais. Estes achados indicam que em carcinomas ductais da mama o número de células em apoptose está diretamente associado à progressão histológica e de outros fatores de mal prognósticos, influenciando no comportamento biológico desses tumores.INCA2005-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/194710.32635/2176-9745.RBC.2005v51n3.1947Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 209-218Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 209-218Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 209-2182176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1947/1181Farias, Rogério EstevamSouza, Andrezza RodriguesAarestrup, Fernando Monteiroinfo:eu-repo/semantics/openAccess2021-11-29T20:30:04Zoai:rbc.inca.gov.br:article/1947Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:30:04Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
Avaliação da apoptose no carcinoma ductal infiltrante da mama: associação com graus histológicos e fatores prognósticos
title Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
spellingShingle Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
Farias, Rogério Estevam
Neoplasias mamárias
Carcinoma de ductos infiltrante
Apoptose
Estadiamento de neoplasias
Breast neoplasms
Infiltrating duct carcinoma
Apoptosis
Neoplasm staging
Prognosis
title_short Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
title_full Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
title_fullStr Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
title_full_unstemmed Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
title_sort Assesment of apoptosis in breast cancer: association with histological grade and prognostic factors
author Farias, Rogério Estevam
author_facet Farias, Rogério Estevam
Souza, Andrezza Rodrigues
Aarestrup, Fernando Monteiro
author_role author
author2 Souza, Andrezza Rodrigues
Aarestrup, Fernando Monteiro
author2_role author
author
dc.contributor.author.fl_str_mv Farias, Rogério Estevam
Souza, Andrezza Rodrigues
Aarestrup, Fernando Monteiro
dc.subject.por.fl_str_mv Neoplasias mamárias
Carcinoma de ductos infiltrante
Apoptose
Estadiamento de neoplasias
Breast neoplasms
Infiltrating duct carcinoma
Apoptosis
Neoplasm staging
Prognosis
topic Neoplasias mamárias
Carcinoma de ductos infiltrante
Apoptose
Estadiamento de neoplasias
Breast neoplasms
Infiltrating duct carcinoma
Apoptosis
Neoplasm staging
Prognosis
description Apoptosis is an important factor of breast cancer growth and is associated to tumoral development. In the present study, the presence of apoptotic cells tumor was investigated in grade I, II and III invasive breast cancer and compared with another prognostic factors. In situ detection of tumor apoptotic cells was investigated by the TUNEL method. Tumor cell proliferation, hormonal receptor, c-erbB-2 and p53 was investigated using immuhistochemical procedure. Our data demonstrated that patients with high apoptotic rate are associated with higher levels of cell proliferation, positive p53 overexpression, negative hormonal expression and high grade breast cancer. Taken together, the results suggested that the rate of apoptosis reflect degrees of histological breast cancer and is associated with another prognostic factors playing an important role in breast cancer biological behavior.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1947
10.32635/2176-9745.RBC.2005v51n3.1947
url https://rbc.inca.gov.br/index.php/revista/article/view/1947
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n3.1947
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1947/1181
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 209-218
Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 209-218
Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 209-218
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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