Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/43 |
Resumo: | Introduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT. |
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Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell TransplantationTerapia Nutricional de Pacientes con Cáncer Infantojuvenil sometidos a Transplante de medula ÒseaTerapia Nutricional de Pacientes com Câncer Infantojuvenil submetidos a Transplante de Células-Tronco HematopoiéticasDietoterapiaNeoplasiasTransplante de Medula ÓsseaNutrição EnteralNutrição ParenteralDiet TherapyNeoplasmsBone Marrow TransplantationEnteral NutritionParenteral NutritionDietoterapiaNeoplasiasTransplante de Médula ÓseaNutrición EnteralNutrición ParenteralIntroduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT.Introducción: El estado nutricional es fuertemente afectado por el proceso de trasplante de médula ósea (TMO). los trastornos nutricionales en los pacientes TMO son comunes y son consecuencia de la enfermedad primaria, de la terapia de citorreducción realizada durante el régimen de condicionamiento y de las complicaciones de éstas, como las infecciones, enterocolitis neutropénica, enfermedad del injerto contra el huésped, entre otras. Objetivo: Realizar una revisión narrativa con base en los principales estudios y posicionamiento de expertos en la literatura, sumado a la experiencia de nuestro grupo. Método: Levantamiento bibliográfico de los principales estudios y consensos sobre los temas terapia nutricional, paciente oncológico, paciente oncológico pediátrico y trasplante TCTH. Resultados: El estado nutricional y la oferta nutricional deficientes pueden influir negativamente en la función inmune durante el estrés metabólico, aumentando el riesgo de complicaciones y desfavorciendo el pronóstico. Las propuestas de intervención nutricional y las principales recomendaciones para la terapia de nutrición oral, enteral y parenteral se revisaron. Dos algoritmos fueron desarrollados, basados en los resultados de la revisión, discriminando las fases del TCTH, con la finalidad de facilitar la decisión de la terapia nutricional. Conclusión: Existen pocas evidencias para basar recomendaciones nutricionales y la terapia nutricional para niños y adolescentes sometidos al TCTH. Muchas informaciones se basan en estudios con adultos o población pediátrica oncológica en tratamiento antineoplásico común. Se necesitan ensayos clínicos controlados para evaluar la aplicabilidad y los beneficios de la terapia nutricional en pacientes pediátricos sometidos a TCTH. Introdução: O estado nutricional é fortemente afetado pelo processo de transplante de células-tronco hematopoiéticas (TCTH). Os distúrbios nutricionais em pacientes TCTH são comuns e são consequência da doença primária, da terapia de citorredução realizada durante o regime de condicionamento e das suas complicações, como as infecções, enterocolite neutropênica, doença do enxerto contra o hospedeiro, entre outras. Objetivo: Realizar uma revisão narrativa com base nos principais estudos e posicionamento de experts na literatura, somado à experiência do nosso grupo. Método: Levantamento bibliográfico dos principais estudos e consensos sobre os temas terapia nutricional, paciente oncológico, paciente oncológico pediátrico e transplante TCTH. Resultados: O estado nutricional e a oferta nutricional deficientes podem influenciar negativamente a função imune durante o estresse metabólico, aumentando o risco de complicações e desfavorecendo o prognóstico. Propostas de intervenção nutricional e as principais recomendações para a terapia de nutrição oral, enteral e parenteral foram revisadas. Dois algoritmos foram desenvolvidos, baseados nos resultados da revisão, discriminando as fases do TCTH, com a finalidade de facilitar a decisão da terapia nutricional. Conclusão: Existem poucas evidências para embasar as recomendações nutricionais e a terapia nutricional para crianças e adolescentes submetidos ao TCTH. Muitas informações são baseadas em estudos com adultos ou população pediátrica oncológica em tratamento antineoplásico comum. Há necessidade de ensaios clínicos controlados para avaliar a aplicabilidade e os benefícios da terapia nutricional em pacientes pediátricos submetidos a TCTH.INCA2018-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/4310.32635/2176-9745.RBC.2018v64n3.43Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 373-381Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 373-381Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 373-3812176-974510.32635/2176-9745.RBC.2018v64n3reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/43/17https://rbc.inca.gov.br/index.php/revista/article/view/43/197Garófolo, AdrianaNakamura, Claudia Harumiinfo:eu-repo/semantics/openAccess2021-11-29T20:06:06Zoai:rbc.inca.gov.br:article/43Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:06:06Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation Terapia Nutricional de Pacientes con Cáncer Infantojuvenil sometidos a Transplante de medula Òsea Terapia Nutricional de Pacientes com Câncer Infantojuvenil submetidos a Transplante de Células-Tronco Hematopoiéticas |
title |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
spellingShingle |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation Garófolo, Adriana Dietoterapia Neoplasias Transplante de Medula Óssea Nutrição Enteral Nutrição Parenteral Diet Therapy Neoplasms Bone Marrow Transplantation Enteral Nutrition Parenteral Nutrition Dietoterapia Neoplasias Transplante de Médula Ósea Nutrición Enteral Nutrición Parenteral |
title_short |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
title_full |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
title_fullStr |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
title_full_unstemmed |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
title_sort |
Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation |
author |
Garófolo, Adriana |
author_facet |
Garófolo, Adriana Nakamura, Claudia Harumi |
author_role |
author |
author2 |
Nakamura, Claudia Harumi |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Garófolo, Adriana Nakamura, Claudia Harumi |
dc.subject.por.fl_str_mv |
Dietoterapia Neoplasias Transplante de Medula Óssea Nutrição Enteral Nutrição Parenteral Diet Therapy Neoplasms Bone Marrow Transplantation Enteral Nutrition Parenteral Nutrition Dietoterapia Neoplasias Transplante de Médula Ósea Nutrición Enteral Nutrición Parenteral |
topic |
Dietoterapia Neoplasias Transplante de Medula Óssea Nutrição Enteral Nutrição Parenteral Diet Therapy Neoplasms Bone Marrow Transplantation Enteral Nutrition Parenteral Nutrition Dietoterapia Neoplasias Transplante de Médula Ósea Nutrición Enteral Nutrición Parenteral |
description |
Introduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/43 10.32635/2176-9745.RBC.2018v64n3.43 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/43 |
identifier_str_mv |
10.32635/2176-9745.RBC.2018v64n3.43 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/43/17 https://rbc.inca.gov.br/index.php/revista/article/view/43/197 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 373-381 Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 373-381 Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 373-381 2176-9745 10.32635/2176-9745.RBC.2018v64n3 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042242108522496 |