Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation

Detalhes bibliográficos
Autor(a) principal: Garófolo, Adriana
Data de Publicação: 2018
Outros Autores: Nakamura, Claudia Harumi
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/43
Resumo: Introduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations  and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT.
id INCA-1_6c05fff1e4222842e2cf6a5b659b57f6
oai_identifier_str oai:rbc.inca.gov.br:article/43
network_acronym_str INCA-1
network_name_str Revista Brasileira de Cancerologia (Online)
repository_id_str
spelling Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell TransplantationTerapia Nutricional de Pacientes con Cáncer Infantojuvenil sometidos a Transplante de medula ÒseaTerapia Nutricional de Pacientes com Câncer Infantojuvenil submetidos a Transplante de Células-Tronco HematopoiéticasDietoterapiaNeoplasiasTransplante de Medula ÓsseaNutrição EnteralNutrição ParenteralDiet TherapyNeoplasmsBone Marrow TransplantationEnteral NutritionParenteral NutritionDietoterapiaNeoplasiasTransplante de Médula ÓseaNutrición EnteralNutrición ParenteralIntroduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations  and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT.Introducción: El estado nutricional es fuertemente afectado por el proceso de trasplante de médula ósea (TMO). los trastornos nutricionales en los pacientes TMO son comunes y son consecuencia de la enfermedad primaria, de la terapia de citorreducción realizada durante el régimen de condicionamiento y de las complicaciones de éstas, como las infecciones, enterocolitis neutropénica, enfermedad del injerto contra el huésped, entre otras. Objetivo: Realizar una revisión narrativa con base en los principales estudios y posicionamiento de expertos en la literatura, sumado a la experiencia de nuestro grupo. Método: Levantamiento bibliográfico de los principales estudios y consensos sobre los temas terapia nutricional, paciente oncológico, paciente oncológico pediátrico y trasplante TCTH. Resultados: El estado nutricional y la oferta nutricional deficientes pueden influir negativamente en la función inmune durante el estrés metabólico, aumentando el riesgo de complicaciones y desfavorciendo el pronóstico. Las propuestas de intervención nutricional y las principales recomendaciones para la terapia de nutrición oral, enteral y parenteral se revisaron. Dos algoritmos fueron desarrollados, basados en los resultados de la revisión, discriminando las fases del TCTH, con la finalidad de facilitar la decisión de la terapia nutricional. Conclusión: Existen pocas evidencias para basar recomendaciones nutricionales y la terapia nutricional para niños y adolescentes sometidos al TCTH. Muchas informaciones se basan en estudios con adultos o población pediátrica oncológica en tratamiento antineoplásico común. Se necesitan ensayos clínicos controlados para evaluar la aplicabilidad y los beneficios de la terapia nutricional en pacientes pediátricos sometidos a TCTH. Introdução: O estado nutricional é fortemente afetado pelo processo de transplante de células-tronco hematopoiéticas (TCTH). Os distúrbios nutricionais em pacientes TCTH são comuns e  são consequência da doença primária, da terapia de citorredução realizada durante o regime de condicionamento e das suas complicações, como as infecções, enterocolite neutropênica, doença do enxerto contra o hospedeiro, entre outras. Objetivo: Realizar uma revisão narrativa com base nos principais estudos e posicionamento de experts na literatura, somado à experiência do nosso grupo. Método: Levantamento bibliográfico dos principais estudos e consensos sobre os temas terapia nutricional, paciente oncológico, paciente oncológico pediátrico e transplante TCTH. Resultados: O estado nutricional e a oferta nutricional deficientes podem influenciar negativamente a função imune durante o estresse metabólico, aumentando o risco de complicações e desfavorecendo o prognóstico. Propostas de intervenção nutricional e as principais recomendações para a terapia de nutrição oral, enteral e parenteral foram revisadas. Dois algoritmos foram desenvolvidos, baseados nos resultados da revisão, discriminando as fases do TCTH, com a finalidade de facilitar a decisão da terapia nutricional. Conclusão: Existem poucas evidências para embasar as recomendações nutricionais e a terapia nutricional para crianças e adolescentes submetidos ao TCTH. Muitas informações são baseadas em estudos com adultos ou população pediátrica oncológica em tratamento antineoplásico comum. Há necessidade de ensaios clínicos controlados para avaliar a aplicabilidade e os benefícios da terapia nutricional em pacientes pediátricos submetidos a TCTH.INCA2018-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/4310.32635/2176-9745.RBC.2018v64n3.43Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 373-381Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 373-381Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 373-3812176-974510.32635/2176-9745.RBC.2018v64n3reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/43/17https://rbc.inca.gov.br/index.php/revista/article/view/43/197Garófolo, AdrianaNakamura, Claudia Harumiinfo:eu-repo/semantics/openAccess2021-11-29T20:06:06Zoai:rbc.inca.gov.br:article/43Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:06:06Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
Terapia Nutricional de Pacientes con Cáncer Infantojuvenil sometidos a Transplante de medula Òsea
Terapia Nutricional de Pacientes com Câncer Infantojuvenil submetidos a Transplante de Células-Tronco Hematopoiéticas
title Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
spellingShingle Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
Garófolo, Adriana
Dietoterapia
Neoplasias
Transplante de Medula Óssea
Nutrição Enteral
Nutrição Parenteral
Diet Therapy
Neoplasms
Bone Marrow Transplantation
Enteral Nutrition
Parenteral Nutrition
Dietoterapia
Neoplasias
Transplante de Médula Ósea
Nutrición Enteral
Nutrición Parenteral
title_short Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
title_full Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
title_fullStr Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
title_full_unstemmed Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
title_sort Nutritional Support in Juvenile Cancer Patients under Hematopoietic Stem Cell Transplantation
author Garófolo, Adriana
author_facet Garófolo, Adriana
Nakamura, Claudia Harumi
author_role author
author2 Nakamura, Claudia Harumi
author2_role author
dc.contributor.author.fl_str_mv Garófolo, Adriana
Nakamura, Claudia Harumi
dc.subject.por.fl_str_mv Dietoterapia
Neoplasias
Transplante de Medula Óssea
Nutrição Enteral
Nutrição Parenteral
Diet Therapy
Neoplasms
Bone Marrow Transplantation
Enteral Nutrition
Parenteral Nutrition
Dietoterapia
Neoplasias
Transplante de Médula Ósea
Nutrición Enteral
Nutrición Parenteral
topic Dietoterapia
Neoplasias
Transplante de Medula Óssea
Nutrição Enteral
Nutrição Parenteral
Diet Therapy
Neoplasms
Bone Marrow Transplantation
Enteral Nutrition
Parenteral Nutrition
Dietoterapia
Neoplasias
Transplante de Médula Ósea
Nutrición Enteral
Nutrición Parenteral
description Introduction: Nutritional status is influenced by hematopoietic stem cell transplantation (HTSC). nutritional disorders in HSCT patients are common and are a consequence of the primary disease, cytoreduction therapy performed during the conditioning regimen and complications such as infections, neutropenic enterocolitis, graft versus host disease, among others. Objective: To carry out a narrative review based on the main studies and positioning of experts in literature, in addition to the experience of our group. Method: Bibliographical survey of the main studies and consensus on the nutritional therapy, oncology patient, pediatric oncology patient and transplantation HSCT. Results: Poor nutritional status and nutritional supply can negatively influence immune function during metabolic stress, increasing the risk of complications and disfavoring the prognosis. Nutritional intervention proposals and the main recommendations for oral, enteral and parenteral nutrition therapy were reviewed. Two algorithms were developed, based on the results of the review, discriminating the phases of HSCT, in order to facilitate the decision of nutritional therapy. Conclusion: There is little evidence to support nutritional recommendations  and nutritional therapy for children and adolescents submitted to HSCT. Much information is based on studies with adults or pediatric population oncology in common antineoplastic treatment. There is a need for controlled clinical trials to evaluate the applicability and benefits of nutritional therapy in pediatric patients undergoing HSCT.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/43
10.32635/2176-9745.RBC.2018v64n3.43
url https://rbc.inca.gov.br/index.php/revista/article/view/43
identifier_str_mv 10.32635/2176-9745.RBC.2018v64n3.43
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/43/17
https://rbc.inca.gov.br/index.php/revista/article/view/43/197
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 64 No. 3 (2018): July/Aug./Sept.; 373-381
Revista Brasileira de Cancerologia; Vol. 64 Núm. 3 (2018): jul./agosto/sept.; 373-381
Revista Brasileira de Cancerologia; v. 64 n. 3 (2018): jul./ago./set.; 373-381
2176-9745
10.32635/2176-9745.RBC.2018v64n3
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1797042242108522496