Impact of the C-MYC oncogene on cancer

Detalhes bibliográficos
Autor(a) principal: Faria, Mário Henrique Girão
Data de Publicação: 2006
Outros Autores: Rabenhorst, Silvia Helena Barem
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1890
Resumo: The C-MYC oncogene has been highlighted as a key element in the tumorigenesis of various human cancers. Recent evidence reinforces the direct and indirect participation of the C-MYC protein in cell cycle regulation, differentiation, metabolism, cell growth, apoptosis, genomic instability, immortality, and angiogenesis. New efforts have focused on the identification of target genes regulated by C-MYC and explaining the molecular mechanisms involved in neoplastic cell transformation. However, the greatest challenge is the development of tools capable of modulating the interaction between the C-MYC protein and its molecular targets, thereby revealing potential therapeutic approaches. The current review discusses general aspects and peculiarities pertaining to C-MYC activation and regulation and considers various cell programs modulated by the C-MYC protein.
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spelling Impact of the C-MYC oncogene on cancerImpacto do oncogene C-MYC no câncerProteínas Proto-oncogênicas C-MycNeoplasiasLiteratura de revisãoProto-Oncogene Proteins c-mycNeoplasmsReview LiteratureThe C-MYC oncogene has been highlighted as a key element in the tumorigenesis of various human cancers. Recent evidence reinforces the direct and indirect participation of the C-MYC protein in cell cycle regulation, differentiation, metabolism, cell growth, apoptosis, genomic instability, immortality, and angiogenesis. New efforts have focused on the identification of target genes regulated by C-MYC and explaining the molecular mechanisms involved in neoplastic cell transformation. However, the greatest challenge is the development of tools capable of modulating the interaction between the C-MYC protein and its molecular targets, thereby revealing potential therapeutic approaches. The current review discusses general aspects and peculiarities pertaining to C-MYC activation and regulation and considers various cell programs modulated by the C-MYC protein.O oncogene C-MYC tem sido apontado como peça central no processo tumorigênico em diversos cânceres humanos. Recentes evidências reforçam as participações direta e indireta da proteína C-MYC na regulação do ciclo celular, diferenciação, metabolismo, crescimento celular, apoptose, instabilidade genômica, imortalidade e angiogênese. Novos esforços estão sendo direcionados no sentido da identificação dos genes-alvo regulados pelo C-MYC e da elucidação dos mecanismos moleculares implicados na transformação neoplásica. O maior desafio, todavia, consiste no desenvolvimento de ferramentas capazes de modular a interação entre a proteína C-MYC e os seus alvos moleculares, desvendando potenciais estratégias terapêuticas. A presente revisão aborda aspectos gerais e peculiaridades quanto à ativação e à regulação do C-MYC, bem como discute os diversos programas celulares modulados pela proteína C-MYC.INCA2006-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/189010.32635/2176-9745.RBC.2006v52n2.1890Revista Brasileira de Cancerologia; Vol. 52 No. 2 (2006): Apr./May/June; 165-171Revista Brasileira de Cancerologia; Vol. 52 Núm. 2 (2006): abr./mayo/jun.; 165-171Revista Brasileira de Cancerologia; v. 52 n. 2 (2006): abr./maio/jun.; 165-1712176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1890/1147Faria, Mário Henrique GirãoRabenhorst, Silvia Helena Bareminfo:eu-repo/semantics/openAccess2021-11-29T20:28:06Zoai:rbc.inca.gov.br:article/1890Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:28:06Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Impact of the C-MYC oncogene on cancer
Impacto do oncogene C-MYC no câncer
title Impact of the C-MYC oncogene on cancer
spellingShingle Impact of the C-MYC oncogene on cancer
Faria, Mário Henrique Girão
Proteínas Proto-oncogênicas C-Myc
Neoplasias
Literatura de revisão
Proto-Oncogene Proteins c-myc
Neoplasms
Review Literature
title_short Impact of the C-MYC oncogene on cancer
title_full Impact of the C-MYC oncogene on cancer
title_fullStr Impact of the C-MYC oncogene on cancer
title_full_unstemmed Impact of the C-MYC oncogene on cancer
title_sort Impact of the C-MYC oncogene on cancer
author Faria, Mário Henrique Girão
author_facet Faria, Mário Henrique Girão
Rabenhorst, Silvia Helena Barem
author_role author
author2 Rabenhorst, Silvia Helena Barem
author2_role author
dc.contributor.author.fl_str_mv Faria, Mário Henrique Girão
Rabenhorst, Silvia Helena Barem
dc.subject.por.fl_str_mv Proteínas Proto-oncogênicas C-Myc
Neoplasias
Literatura de revisão
Proto-Oncogene Proteins c-myc
Neoplasms
Review Literature
topic Proteínas Proto-oncogênicas C-Myc
Neoplasias
Literatura de revisão
Proto-Oncogene Proteins c-myc
Neoplasms
Review Literature
description The C-MYC oncogene has been highlighted as a key element in the tumorigenesis of various human cancers. Recent evidence reinforces the direct and indirect participation of the C-MYC protein in cell cycle regulation, differentiation, metabolism, cell growth, apoptosis, genomic instability, immortality, and angiogenesis. New efforts have focused on the identification of target genes regulated by C-MYC and explaining the molecular mechanisms involved in neoplastic cell transformation. However, the greatest challenge is the development of tools capable of modulating the interaction between the C-MYC protein and its molecular targets, thereby revealing potential therapeutic approaches. The current review discusses general aspects and peculiarities pertaining to C-MYC activation and regulation and considers various cell programs modulated by the C-MYC protein.
publishDate 2006
dc.date.none.fl_str_mv 2006-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1890
10.32635/2176-9745.RBC.2006v52n2.1890
url https://rbc.inca.gov.br/index.php/revista/article/view/1890
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n2.1890
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1890/1147
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 2 (2006): Apr./May/June; 165-171
Revista Brasileira de Cancerologia; Vol. 52 Núm. 2 (2006): abr./mayo/jun.; 165-171
Revista Brasileira de Cancerologia; v. 52 n. 2 (2006): abr./maio/jun.; 165-171
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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