Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study

Detalhes bibliográficos
Autor(a) principal: Valente, Patricia Marques Soares
Data de Publicação: 2019
Outros Autores: Braga, Eduardo Pinho, Neves, Thamires Ferreira, Souza, Walter Claudino Pires de, Silva, Thamires Lopes da, Martins, Wolney de Andrade, Castilho, Selma Rodrigues de
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/314
Resumo: Introduction: Cardiotoxicity is one of the most significant effects of oncological treatment. Among the major relevant consequences, heart failure with systolic or diastolic ventricular dysfunction stands out. Case report: 39-year-old female patient with diffuse large B-cell non-Hodgkin's lymphoma who underwent rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP chemotherapy) and presented fatigue while exerting small efforts and increased blood pressure. The echocardiogram showed mild left ventricular dysfunction with diffuse hypokinesia and reduction of left ventricular ejection fraction (LVEF) associated with the possible cardiomyotoxicity of doxorubicin. The case was identified in a chart survey, and analyzed according to the Naranjo Algorithm, and then the severity of the adverse cardiovascular reactions was determined. Conclusion: This study highlights the importance of the active search for cardiovascular events in medical charts of patients undergoing cardiotoxic chemotherapy and the role of pharmacovigilance in this context.
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spelling Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case StudyInvestigación de Cardiotoxicidad en Prontuario de Paciente Sometido a la Quimioterapia R-CHOP: un Estudio de CasoPesquisa de Cardiotoxicidade em Prontuário de Paciente Submetido à Quimioterapia R-CHOP: um Estudo de CasoCardiotoxicidadeDoxorrubicina/uso terapêuticoFarmacovigilânciaRegistros MédicosRelatos de CasosCardiotoxicityDoxorubicin/therapeutic usePharmacovigilanceMedical RecordsCase ReportsCardiotoxicidadDoxorubicina/uso terapéuticoFarmacovigilanciaRegistros MédicosInformes de CasosIntroduction: Cardiotoxicity is one of the most significant effects of oncological treatment. Among the major relevant consequences, heart failure with systolic or diastolic ventricular dysfunction stands out. Case report: 39-year-old female patient with diffuse large B-cell non-Hodgkin's lymphoma who underwent rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP chemotherapy) and presented fatigue while exerting small efforts and increased blood pressure. The echocardiogram showed mild left ventricular dysfunction with diffuse hypokinesia and reduction of left ventricular ejection fraction (LVEF) associated with the possible cardiomyotoxicity of doxorubicin. The case was identified in a chart survey, and analyzed according to the Naranjo Algorithm, and then the severity of the adverse cardiovascular reactions was determined. Conclusion: This study highlights the importance of the active search for cardiovascular events in medical charts of patients undergoing cardiotoxic chemotherapy and the role of pharmacovigilance in this context.Introducción: La cardiotoxicidad es uno de los efectos más significativos del tratamiento oncológico. Entre los efectos más considerables, destaca la insuficiencia cardíaca con disfunción ventricular sistólica o diastólica. Relato del caso: Paciente de 39 años con linfoma no Hodgkin difuso de células grandes B que se sometieron a quimioterapia con rituximab, ciclofosfamida, doxorubicina, vincristina y prednisona (R-CHOP). Pequeños esfuerzos y aumento de la presión arterial. El ecocardiograma mostró una disfunción ventricular izquierda leve con hipocinesia difusa y reducción de la fracción de eyección del ventrículo izquierdo (FEVI) asociada con la posible cardiomioxicidad de la doxorrubicina. El caso se identificó en una encuesta gráfica y se analizó de acuerdo con el algoritmo de Naranjo, y luego se determinó la gravedad de las reacciones cardiovasculares adversas. Conclusión: Este estudio destaca la importancia de la búsqueda activa de eventos cardiovasculares en los registros médicos de pacientes sometidos a quimioterapia cardiotóxica y el papel de la farmacovigilancia en este contexto.Introdução: A cardiotoxicidade é um dos efeitos mais significativos no tratamento oncológico. Entre as implicações mais consideráveis, destaca-se a insuficiência cardíaca com disfunção ventricular sistólica ou diastólica. Relato do caso: Paciente do sexo feminino, 39 anos, com linfoma não Hodgkin difuso de grandes células B, submetida à quimioterapia com rituximabe, ciclofosfamida, doxorrubicina, vincristina e prednisona (R-CHOP), que apresentou cansaço aos pequenos esforços e aumento da pressão arterial. O ecocardiograma demonstrou disfunção ventricular esquerda leve com hipocinesia difusa e redução da fração de ejeção do ventrículo esquerdo (FEVE), associadas à possível cardiomiotoxicidade da doxorrubicina. O caso foi identificado em uma pesquisa de prontuário e analisado segundo o algoritmo de Naranjo e, em seguida, foi determinada a gravidade das reações adversas cardiovasculares. Conclusão: Este estudo ressalta a importância da busca ativa de eventos cardiovasculares em prontuários de pacientes submetidos à quimioterapia cardiotóxica e do papel da farmacovigilância nesse contexto.INCA2019-11-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/31410.32635/2176-9745.RBC.2019v65n3.314Revista Brasileira de Cancerologia; Vol. 65 No. 3 (2019): July/Aug./Sept.; e-06314Revista Brasileira de Cancerologia; Vol. 65 Núm. 3 (2019): jul./agosto/sept.; e-06314Revista Brasileira de Cancerologia; v. 65 n. 3 (2019): jul./ago./set.; e-063142176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/314/483https://rbc.inca.gov.br/index.php/revista/article/view/314/607Copyright (c) 2019 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessValente, Patricia Marques SoaresBraga, Eduardo PinhoNeves, Thamires FerreiraSouza, Walter Claudino Pires deSilva, Thamires Lopes daMartins, Wolney de AndradeCastilho, Selma Rodrigues de2021-11-29T20:03:37Zoai:rbc.inca.gov.br:article/314Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:03:37Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
Investigación de Cardiotoxicidad en Prontuario de Paciente Sometido a la Quimioterapia R-CHOP: un Estudio de Caso
Pesquisa de Cardiotoxicidade em Prontuário de Paciente Submetido à Quimioterapia R-CHOP: um Estudo de Caso
title Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
spellingShingle Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
Valente, Patricia Marques Soares
Cardiotoxicidade
Doxorrubicina/uso terapêutico
Farmacovigilância
Registros Médicos
Relatos de Casos
Cardiotoxicity
Doxorubicin/therapeutic use
Pharmacovigilance
Medical Records
Case Reports
Cardiotoxicidad
Doxorubicina/uso terapéutico
Farmacovigilancia
Registros Médicos
Informes de Casos
title_short Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
title_full Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
title_fullStr Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
title_full_unstemmed Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
title_sort Research on Cardiotoxicity in Patient Chart Submitted to R-CHOP Chemotherapy: a Case Study
author Valente, Patricia Marques Soares
author_facet Valente, Patricia Marques Soares
Braga, Eduardo Pinho
Neves, Thamires Ferreira
Souza, Walter Claudino Pires de
Silva, Thamires Lopes da
Martins, Wolney de Andrade
Castilho, Selma Rodrigues de
author_role author
author2 Braga, Eduardo Pinho
Neves, Thamires Ferreira
Souza, Walter Claudino Pires de
Silva, Thamires Lopes da
Martins, Wolney de Andrade
Castilho, Selma Rodrigues de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Valente, Patricia Marques Soares
Braga, Eduardo Pinho
Neves, Thamires Ferreira
Souza, Walter Claudino Pires de
Silva, Thamires Lopes da
Martins, Wolney de Andrade
Castilho, Selma Rodrigues de
dc.subject.por.fl_str_mv Cardiotoxicidade
Doxorrubicina/uso terapêutico
Farmacovigilância
Registros Médicos
Relatos de Casos
Cardiotoxicity
Doxorubicin/therapeutic use
Pharmacovigilance
Medical Records
Case Reports
Cardiotoxicidad
Doxorubicina/uso terapéutico
Farmacovigilancia
Registros Médicos
Informes de Casos
topic Cardiotoxicidade
Doxorrubicina/uso terapêutico
Farmacovigilância
Registros Médicos
Relatos de Casos
Cardiotoxicity
Doxorubicin/therapeutic use
Pharmacovigilance
Medical Records
Case Reports
Cardiotoxicidad
Doxorubicina/uso terapéutico
Farmacovigilancia
Registros Médicos
Informes de Casos
description Introduction: Cardiotoxicity is one of the most significant effects of oncological treatment. Among the major relevant consequences, heart failure with systolic or diastolic ventricular dysfunction stands out. Case report: 39-year-old female patient with diffuse large B-cell non-Hodgkin's lymphoma who underwent rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP chemotherapy) and presented fatigue while exerting small efforts and increased blood pressure. The echocardiogram showed mild left ventricular dysfunction with diffuse hypokinesia and reduction of left ventricular ejection fraction (LVEF) associated with the possible cardiomyotoxicity of doxorubicin. The case was identified in a chart survey, and analyzed according to the Naranjo Algorithm, and then the severity of the adverse cardiovascular reactions was determined. Conclusion: This study highlights the importance of the active search for cardiovascular events in medical charts of patients undergoing cardiotoxic chemotherapy and the role of pharmacovigilance in this context.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/314
10.32635/2176-9745.RBC.2019v65n3.314
url https://rbc.inca.gov.br/index.php/revista/article/view/314
identifier_str_mv 10.32635/2176-9745.RBC.2019v65n3.314
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/314/483
https://rbc.inca.gov.br/index.php/revista/article/view/314/607
dc.rights.driver.fl_str_mv Copyright (c) 2019 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 65 No. 3 (2019): July/Aug./Sept.; e-06314
Revista Brasileira de Cancerologia; Vol. 65 Núm. 3 (2019): jul./agosto/sept.; e-06314
Revista Brasileira de Cancerologia; v. 65 n. 3 (2019): jul./ago./set.; e-06314
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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