ATRA Syndrome:10 year experience
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2120 |
Resumo: | Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) responsible for 10% of all AMLs. Usually, the treatment of APL consists of chemotherapy and all-trans retinoic acid (ATRA) administration. The major side effect of ATRA is the socalled "ATRA syndrome", which has an incidence of nearly 30%. We studied the clinical presentation and the incidence of ATRA syndrome in patients with APL admitted to Hospital São Paulo-UNIFESP-EPM. Thirteen patients with APL received ATRA. ATRA syndrome was diagnosed in 5 patients (38%) with a mean age of 29 years old, which were, in average, in the 10th day of the use of ATRA. The most frequent clinical findings were respiratory distress, pulmonary infiltrate on chest X-Ray and fever. This report calls attention to the need of early diagnosis of the syndrome with prompt introduction of dexamethasone at the first sign in order to obtain therapeutic success. |
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ATRA Syndrome:10 year experienceSíndrome Atra: experiência de 10 anosLeucemia Promielocítica AgudaDiagnósticoQuimioterapiaÁcido TransretinóicoSíndrome ATRAAcute Promyelocytic LeukemiaDiagnosisChemotherapyAll-Trans Retinoic AcidATRA SyndromeAcute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) responsible for 10% of all AMLs. Usually, the treatment of APL consists of chemotherapy and all-trans retinoic acid (ATRA) administration. The major side effect of ATRA is the socalled "ATRA syndrome", which has an incidence of nearly 30%. We studied the clinical presentation and the incidence of ATRA syndrome in patients with APL admitted to Hospital São Paulo-UNIFESP-EPM. Thirteen patients with APL received ATRA. ATRA syndrome was diagnosed in 5 patients (38%) with a mean age of 29 years old, which were, in average, in the 10th day of the use of ATRA. The most frequent clinical findings were respiratory distress, pulmonary infiltrate on chest X-Ray and fever. This report calls attention to the need of early diagnosis of the syndrome with prompt introduction of dexamethasone at the first sign in order to obtain therapeutic success.A leucemia promielocítica aguda (LPA) é um subtipo de leucemia mielóide aguda (LMA) responsável por 10% de todas as LMAs. Geralmente, o tratamento da LPA consiste de quimioterapia e uso de ácido transretinóico (ATRA). O maior efeito colateral do ATRA é a "Síndrome ATRA", que ocorre com uma freqüência de quase 30%. Estudamos a apresentação clínica e a incidência da Síndrome ATRA em pacientes com LPA admitidos no Hospital São Paulo (da Escola Paulista de Medicina-UNIFESP). Treze pacientes com LPA fizeram uso de ATRA. A síndrome foi diagnosticada em cinco pacientes (38%) com idade média de 29 anos e que estavam,em média, no décimo dia do uso de ATRA. Os achados clínicos mais freqüentes foram insuficiência respiratória, infiltrado pulmonar à radiografia e febre. Este relato chama a atenção para a necessidade do diagnóstico precoce dessa síndrome, com a introdução de dexametasona ao primeiro sinal no intuito de êxito terapêutico.INCA2003-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/212010.32635/2176-9745.RBC.2003v49n1.2120Revista Brasileira de Cancerologia; Vol. 49 No. 1 (2003): Jan./Feb./Mar; 27-31Revista Brasileira de Cancerologia; Vol. 49 Núm. 1 (2003): ene./feb./mar.; 27-31Revista Brasileira de Cancerologia; v. 49 n. 1 (2003): jan./fev./mar.; 27-312176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2120/1315Pinheiro, Ronald Feitosa Pelloso, Luis Arthur Flores Yamamoto, Mihoko Chauffaille, Maria de Lourdes Lopes Ferrari Bordim, José Orlando info:eu-repo/semantics/openAccess2021-11-29T20:36:15Zoai:rbc.inca.gov.br:article/2120Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:36:15Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
ATRA Syndrome:10 year experience Síndrome Atra: experiência de 10 anos |
title |
ATRA Syndrome:10 year experience |
spellingShingle |
ATRA Syndrome:10 year experience Pinheiro, Ronald Feitosa Leucemia Promielocítica Aguda Diagnóstico Quimioterapia Ácido Transretinóico Síndrome ATRA Acute Promyelocytic Leukemia Diagnosis Chemotherapy All-Trans Retinoic Acid ATRA Syndrome |
title_short |
ATRA Syndrome:10 year experience |
title_full |
ATRA Syndrome:10 year experience |
title_fullStr |
ATRA Syndrome:10 year experience |
title_full_unstemmed |
ATRA Syndrome:10 year experience |
title_sort |
ATRA Syndrome:10 year experience |
author |
Pinheiro, Ronald Feitosa |
author_facet |
Pinheiro, Ronald Feitosa Pelloso, Luis Arthur Flores Yamamoto, Mihoko Chauffaille, Maria de Lourdes Lopes Ferrari Bordim, José Orlando |
author_role |
author |
author2 |
Pelloso, Luis Arthur Flores Yamamoto, Mihoko Chauffaille, Maria de Lourdes Lopes Ferrari Bordim, José Orlando |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Pinheiro, Ronald Feitosa Pelloso, Luis Arthur Flores Yamamoto, Mihoko Chauffaille, Maria de Lourdes Lopes Ferrari Bordim, José Orlando |
dc.subject.por.fl_str_mv |
Leucemia Promielocítica Aguda Diagnóstico Quimioterapia Ácido Transretinóico Síndrome ATRA Acute Promyelocytic Leukemia Diagnosis Chemotherapy All-Trans Retinoic Acid ATRA Syndrome |
topic |
Leucemia Promielocítica Aguda Diagnóstico Quimioterapia Ácido Transretinóico Síndrome ATRA Acute Promyelocytic Leukemia Diagnosis Chemotherapy All-Trans Retinoic Acid ATRA Syndrome |
description |
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) responsible for 10% of all AMLs. Usually, the treatment of APL consists of chemotherapy and all-trans retinoic acid (ATRA) administration. The major side effect of ATRA is the socalled "ATRA syndrome", which has an incidence of nearly 30%. We studied the clinical presentation and the incidence of ATRA syndrome in patients with APL admitted to Hospital São Paulo-UNIFESP-EPM. Thirteen patients with APL received ATRA. ATRA syndrome was diagnosed in 5 patients (38%) with a mean age of 29 years old, which were, in average, in the 10th day of the use of ATRA. The most frequent clinical findings were respiratory distress, pulmonary infiltrate on chest X-Ray and fever. This report calls attention to the need of early diagnosis of the syndrome with prompt introduction of dexamethasone at the first sign in order to obtain therapeutic success. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-03-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2120 10.32635/2176-9745.RBC.2003v49n1.2120 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2120 |
identifier_str_mv |
10.32635/2176-9745.RBC.2003v49n1.2120 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2120/1315 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 49 No. 1 (2003): Jan./Feb./Mar; 27-31 Revista Brasileira de Cancerologia; Vol. 49 Núm. 1 (2003): ene./feb./mar.; 27-31 Revista Brasileira de Cancerologia; v. 49 n. 1 (2003): jan./fev./mar.; 27-31 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042249521954816 |