Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer

Detalhes bibliográficos
Autor(a) principal: Maio, Regiane
Data de Publicação: 2010
Outros Autores: Berto, José Carlos, Corrêa, Camila Renata, Campana, Álvaro Oscar, Paiva, Sérgio Alberto Rupp
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1518
Resumo: The aim of this article is to characterize a group of patients with oral cavity and oropharyngeal cancer in regard to their dietary intake, as well as serum and oral tissue concentrations of carotenoids. A transversal study was undertaken with 37 male and 11 female patients, aging from 39 to 77, without previous treatment for the disease. Oral biopsies were taken during surgery in all patients. Tissue determination of carotenoids was done by High Performance Liquid Chromatography (HPLClc) using C18 columns. It was verified that the habitual daily dietary intakes of carotenoids were 3,859; 1,994; 1,345; 508; 102 and 78mg/day for all carotenoids, lycopene, beta-carotene, lutein/zeaxantin, alpha-carotene and beta-cryptoxanthin, respectively. The largest concentrations of carotenoids in the serum were verified for lycopene (0.54mmol/L) and lutein/zeaxantin (0.31mmol/L). In the normal tissue, concentrations were 3.49; 1.15; 0.12 and 0.09mmol/kg for lutein/zeaxantin, lycopene, beta-carotene and beta-cryptoxanthin, respectively. These figures were not statistically different from neoplastic tissues. Lycopene was the predominant carotenoid in the diet (53%) and serum (45%), whereas in the tissues it was lutein/zeaxantin (64-65%). Significant correlations (r=0.28 to r=0.70) between the amount of carotenoids in the diet, in the serum and in the oral tissue were observed for the majority of the carotenoids. Lycopene was identified as the main carotenoid in the diet and in the serum, whereas lutein/zeaxantin was predominant in the oral tissue. No depletion was observed in carotenoids investigated in the neoplastic tissue in the studied group.
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spelling Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal CancerIngesta Dietética, Concentraciones Séricas y Tisulares Bucales de Carotenoides en Pacientes con Carcinoma Epidermoide de Cavidad Bucal y OrofaringeIngestão Dietética, Concentrações Séricas e Teciduais Orais de Carotenoides em Pacientes com Carcinoma Epidermoide da Cavidade Oral e da OrofaringeCarotenoidesTecidosMucosa BucalNeoplasias BucaisIngestão de AlimentosEstudos TransversaisCarotenoidsTissuesMouth MucosaMouth NeoplasmsEatingCross-Sectional StudiesCarotenóidesTejidosMucosa BucalNeoplasias de la BocaIngestión de AlimentosEstudios TransversalesThe aim of this article is to characterize a group of patients with oral cavity and oropharyngeal cancer in regard to their dietary intake, as well as serum and oral tissue concentrations of carotenoids. A transversal study was undertaken with 37 male and 11 female patients, aging from 39 to 77, without previous treatment for the disease. Oral biopsies were taken during surgery in all patients. Tissue determination of carotenoids was done by High Performance Liquid Chromatography (HPLClc) using C18 columns. It was verified that the habitual daily dietary intakes of carotenoids were 3,859; 1,994; 1,345; 508; 102 and 78mg/day for all carotenoids, lycopene, beta-carotene, lutein/zeaxantin, alpha-carotene and beta-cryptoxanthin, respectively. The largest concentrations of carotenoids in the serum were verified for lycopene (0.54mmol/L) and lutein/zeaxantin (0.31mmol/L). In the normal tissue, concentrations were 3.49; 1.15; 0.12 and 0.09mmol/kg for lutein/zeaxantin, lycopene, beta-carotene and beta-cryptoxanthin, respectively. These figures were not statistically different from neoplastic tissues. Lycopene was the predominant carotenoid in the diet (53%) and serum (45%), whereas in the tissues it was lutein/zeaxantin (64-65%). Significant correlations (r=0.28 to r=0.70) between the amount of carotenoids in the diet, in the serum and in the oral tissue were observed for the majority of the carotenoids. Lycopene was identified as the main carotenoid in the diet and in the serum, whereas lutein/zeaxantin was predominant in the oral tissue. No depletion was observed in carotenoids investigated in the neoplastic tissue in the studied group.Con el objetivo de caracterizar pacientes con cáncer de cavidad bucal y orofaringe, en cuanto a la ingesta alimentar y concentraciones de carotenoides en el suero y tejido bucal, se llevó a cabo un estudio transversal implicando 37 pacientes hombres y 11 mujeres, de edades comprendidas entre 39 y 77 años, sin tratamiento previo de la enfermedad. Las biopsias en la cavidad bucal se lograron durante la cirugía en todos los pacientes. La determinación tisular de carotenoides fue realizada por Cromatografía Líquida de Alta Eficiencia (HPLC), utilizando la columna C18. Las ingestas habituales diarias de carotenoides fueron 3.859, 1.994, 1.345, 508, 102 e 78mg/día para el total de carotenoides, licopeno, betacaroteno, luteína/zeaxantina, alfacaroteno y betacriptoxantina, respectivamente. Las mayores concentraciones de carotenoides en el suero fueron observadas para el licopeno (0,54mmol/L) y para la luteína/zeaxantina (0,31mmol/L). En el tejido normal, las concentraciones encontradas fueron 3,49; 1,15; 0,12 e 0,09mmol/kg para la luteína/zeaxantina, el licopeno, el betacaroteno y la betacriptoxantina, respectivamente; esos valores no fueron estadísticamente diferentes en relación a los del tejido neoplásico. El licopeno fue el carotenoide predominante en la dieta (53%) y en el suero (45%). En los tejidos, hubo un predominio de la luteína/zeaxantina (64-65%). Correlaciones significativas (r=0,28 a r=0,70), entre los valores de carotenoides en la dieta, en el suero y tejido bucal fueron observadas en la mayoría de los carotenoides. El licopeno fue identificado como el principal carotenoide en la dieta y en el suero, en cambio la luteína/zeaxantina predominó en el tejido bucal. No se observó agotamiento de los carotenoides investigados en el tejido bucal neoplásico del grupo estudiado.Com o objetivo de caracterizar pacientes com cânceres da cavidade oral e da orofaringe, quanto à ingestão alimentar e às concentrações de carotenoides no soro e tecido oral, foi realizado estudo transversal envolvendo 37 pacientes homens e 11 mulheres, com idade entre 39 e 77 anos, sem tratamento anterior da doença. As biópsias orais foram obtidas durante o ato cirúrgico em todos pacientes. Determinação tecidual de carotenoides foi realizada por Cromatografia Líquida de Alta Eficiência (CLAEclae), utilizando a coluna C18. As ingestões dietéticas habituais diárias de carotenoides foram 3.859, 1.994, 1.345, 508, 102 e 78mg/dia para o total de carotenoides, licopeno, betacaroteno, luteína/zeaxantina, alfacaroteno e betacriptoxantina, respectivamente. As maiores concentrações de carotenoides no soro foram verificadas para o licopeno (0,54mmol/L) e a luteína/zeaxantina (0,31mmol/L). No tecido normal, as concentrações encontradas foram 3,49; 1,15; 0,12 e 0,09mmol/kg para a luteína/zeaxantina, licopeno, betacaroteno e betacriptoxantina, respectivamente; esses valores não foram estatisticamente diferentes em relação aos do tecido neoplásico. O licopeno foi o carotenoide predominante na dieta (53%) e no soro (45%). Nos tecidos, houve predomínio da luteína/zeaxantina (64%-65%). Correlações significativas (r=0,28 a r=0,70), entre os valores de carotenoides na dieta, no soro e tecido oral, foram observadas para a maioria dos carotenoides. O licopeno foi identificado como o principal carotenoide na dieta e no soro, enquanto a luteína/zeaxantina predominou no tecido oral. Não foi observada depleção dos carotenoides investigados no tecido oral neoplásico no grupo estudado.INCA2010-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/151810.32635/2176-9745.RBC.2010v56n1.1518Revista Brasileira de Cancerologia; Vol. 56 No. 1 (2010): Jan./Feb./Mar.; 7-15Revista Brasileira de Cancerologia; Vol. 56 Núm. 1 (2010): ene./feb.mar.; 7-15Revista Brasileira de Cancerologia; v. 56 n. 1 (2010): jan./fev./mar.; 7-152176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1518/915Maio, Regiane Berto, José Carlos Corrêa, Camila Renata Campana, Álvaro Oscar Paiva, Sérgio Alberto Rupp info:eu-repo/semantics/openAccess2021-11-29T20:19:39Zoai:rbc.inca.gov.br:article/1518Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:19:39Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
Ingesta Dietética, Concentraciones Séricas y Tisulares Bucales de Carotenoides en Pacientes con Carcinoma Epidermoide de Cavidad Bucal y Orofaringe
Ingestão Dietética, Concentrações Séricas e Teciduais Orais de Carotenoides em Pacientes com Carcinoma Epidermoide da Cavidade Oral e da Orofaringe
title Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
spellingShingle Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
Maio, Regiane
Carotenoides
Tecidos
Mucosa Bucal
Neoplasias Bucais
Ingestão de Alimentos
Estudos Transversais
Carotenoids
Tissues
Mouth Mucosa
Mouth Neoplasms
Eating
Cross-Sectional Studies
Carotenóides
Tejidos
Mucosa Bucal
Neoplasias de la Boca
Ingestión de Alimentos
Estudios Transversales
title_short Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
title_full Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
title_fullStr Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
title_full_unstemmed Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
title_sort Dietary Intake, Serum Concentrations, and Oral Tissue Concentrations of Carotenoids in Patients with Oral Cavity and Oropharyngeal Cancer
author Maio, Regiane
author_facet Maio, Regiane
Berto, José Carlos
Corrêa, Camila Renata
Campana, Álvaro Oscar
Paiva, Sérgio Alberto Rupp
author_role author
author2 Berto, José Carlos
Corrêa, Camila Renata
Campana, Álvaro Oscar
Paiva, Sérgio Alberto Rupp
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maio, Regiane
Berto, José Carlos
Corrêa, Camila Renata
Campana, Álvaro Oscar
Paiva, Sérgio Alberto Rupp
dc.subject.por.fl_str_mv Carotenoides
Tecidos
Mucosa Bucal
Neoplasias Bucais
Ingestão de Alimentos
Estudos Transversais
Carotenoids
Tissues
Mouth Mucosa
Mouth Neoplasms
Eating
Cross-Sectional Studies
Carotenóides
Tejidos
Mucosa Bucal
Neoplasias de la Boca
Ingestión de Alimentos
Estudios Transversales
topic Carotenoides
Tecidos
Mucosa Bucal
Neoplasias Bucais
Ingestão de Alimentos
Estudos Transversais
Carotenoids
Tissues
Mouth Mucosa
Mouth Neoplasms
Eating
Cross-Sectional Studies
Carotenóides
Tejidos
Mucosa Bucal
Neoplasias de la Boca
Ingestión de Alimentos
Estudios Transversales
description The aim of this article is to characterize a group of patients with oral cavity and oropharyngeal cancer in regard to their dietary intake, as well as serum and oral tissue concentrations of carotenoids. A transversal study was undertaken with 37 male and 11 female patients, aging from 39 to 77, without previous treatment for the disease. Oral biopsies were taken during surgery in all patients. Tissue determination of carotenoids was done by High Performance Liquid Chromatography (HPLClc) using C18 columns. It was verified that the habitual daily dietary intakes of carotenoids were 3,859; 1,994; 1,345; 508; 102 and 78mg/day for all carotenoids, lycopene, beta-carotene, lutein/zeaxantin, alpha-carotene and beta-cryptoxanthin, respectively. The largest concentrations of carotenoids in the serum were verified for lycopene (0.54mmol/L) and lutein/zeaxantin (0.31mmol/L). In the normal tissue, concentrations were 3.49; 1.15; 0.12 and 0.09mmol/kg for lutein/zeaxantin, lycopene, beta-carotene and beta-cryptoxanthin, respectively. These figures were not statistically different from neoplastic tissues. Lycopene was the predominant carotenoid in the diet (53%) and serum (45%), whereas in the tissues it was lutein/zeaxantin (64-65%). Significant correlations (r=0.28 to r=0.70) between the amount of carotenoids in the diet, in the serum and in the oral tissue were observed for the majority of the carotenoids. Lycopene was identified as the main carotenoid in the diet and in the serum, whereas lutein/zeaxantin was predominant in the oral tissue. No depletion was observed in carotenoids investigated in the neoplastic tissue in the studied group.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1518
10.32635/2176-9745.RBC.2010v56n1.1518
url https://rbc.inca.gov.br/index.php/revista/article/view/1518
identifier_str_mv 10.32635/2176-9745.RBC.2010v56n1.1518
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1518/915
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 56 No. 1 (2010): Jan./Feb./Mar.; 7-15
Revista Brasileira de Cancerologia; Vol. 56 Núm. 1 (2010): ene./feb.mar.; 7-15
Revista Brasileira de Cancerologia; v. 56 n. 1 (2010): jan./fev./mar.; 7-15
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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