Role of the Human Papillomavirus Early Proteins in the Carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Pereira de Lima, Marcos Antonio
Data de Publicação: 2013
Outros Autores: Gleidiston Lima da Silva, Cláudio, Barem Rabenhorst, Silvia Helena
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/983
Resumo: Introduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance.
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spelling Role of the Human Papillomavirus Early Proteins in the CarcinogenesisEl papel de las Proteínas Tempranas del Virus del Papiloma Humano en la CarcinogénesisPapel das Proteínas Precoces do Papilomavírus Humano na CarcinogêneseHumanosInfecções por PapillomavirusPapillomaviridae-classificaçãoCarcionógenosProteínas Oncogênicas ViraisHumansPapillomavirus InfectionsPapillomaviridae-classificationCarcinogensOncogene Proteins, ViralHumanosInfecciones por PapillomavirusPapillomaviridae-classificacíonCarcionógenosProteinas Oncogénicas ViralesIntroduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance.Introducción: El Virus del Papiloma Humano (VPH) es un agente epiteliotropico que tiene mas de 100 genotipos. Entre ellos, algunos estan considerados de alto riesgo debido al potencial para inducir al desarrollo de lesiones malignas, tales como el carcinoma de cuello uterino, cuyo porcentaje de asociacion con el mencionado virus representa casi el 90%. En las celulas infectadas, dos proteinas virales desarrollan un papel importante en la tumorigenesis. Objetivo: Realizar una revision de los estudios existentes en la literatura cientifica internacional centrandose en el papel de las proteinas virales del VPH en la carcinogenesis. Método: Los articulos utilizados para la realizacion de esta revision fueron seleccionados y conseguidos en su version completa en los portales electronicos: Pubmed y Periodicos Capes. Las palabras claves utilizadas en la busqueda fueron: Virus del Papiloma Humano, VPH, las proteinas virales, E5, E6 y E7. Resultados: Proteinas virales E6 y E7 son ampliamente conocidas porque promueven la degradacion de las proteinas celulares p53 y pRb, respectivamente, efecto que es responsable por la mayor parte del potencial oncogenico de los genotipos de alto riesgo de PVH, los cuales son funcionalmente equivalentes a las mutaciones de estos genes celulares, que se observan comunmente en muchos tumores. Sin embargo, otros estudios han demostrado que estas proteinas virales tambien estan implicadas en otras vias tumorales, lo que demuestra una vez mas su importancia en este proceso. Por otra parte, algunos estudios senalan a la proteina E5 como un adyuvante en la carcinogenesis. Conclusión: Los distintos efectos observados de las proteinas tempranas virales culminan en favor de la proliferacion incontrolada de celulas, la inmortalizacion, la regulacion de la diferenciacion celular, la susceptibilidad a la metastasis y el escape de la vigilancia inmunologica.Introdução: O Papilomavírus Humano (HPV) e um agente epiteliotrópico que apresenta mais de 100 genótipos. Destes, alguns são considerados de alto risco devido ao potencial para induzir o surgimento de lesões malignas, como o carcinoma cervical, cujo percentual de associação com o referido vírus e de aproximadamente 90%. Nas células infectadas, duas proteínas virais desempenham papel fundamental na tumorigênese. Objetivo: Realizar uma revisão dos trabalhos existentes na literatura cientifica internacional com enfoque no papel das proteínas virais do HPV na carcinogênese. Método: Os artigos utilizados para a realização da presente revisão foram selecionados e obtidos na integra nos portais eletrônicos PubMed e Periódicos Capes. Os descritores utilizados na busca incluíram: Human Papillomavirus, HPV, viral proteins, E5, E6 e E7. Resultados: As proteínas virais E6 e E7 são amplamente conhecidas por promoverem a degradação das proteínas celulares p53 e pRb, respectivamente, efeito que responde por grande parte do potencial ontogênico dos genótipos de alto risco de HPV, sendo funcionalmente equivalentes a mutações dos referidos genes celulares, que são comumente observadas em diversos tumores. Contudo, novos estudos tem demonstrado que essas proteínas virais também estão envolvidas em diversas outras vias tumorais, denotando novamente a relevância das mesmas nesse processo. Ademais, alguns trabalhos apontam a proteína E5 como coadjuvante na carcinogênese. Conclusão: Os diversos efeitos constatados das proteínas precoces virais culminam no favorecimento da proliferação celular descontrolada, imortalização, regulação da diferenciação celular, suscetibilidade a metástase e escape da vigilância imunológica.INCA2013-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/98310.32635/2176-9745.RBC.2013v59n4.983Revista Brasileira de Cancerologia; Vol. 59 No. 4 (2013): Oct./Nov./Dec.; 565-573Revista Brasileira de Cancerologia; Vol. 59 Núm. 4 (2013): oct./nov./dic.; 565-573Revista Brasileira de Cancerologia; v. 59 n. 4 (2013): out./nov./dez.; 565-5732176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/983/592Pereira de Lima, Marcos AntonioGleidiston Lima da Silva, CláudioBarem Rabenhorst, Silvia Helenainfo:eu-repo/semantics/openAccess2021-11-29T20:10:40Zoai:rbc.inca.gov.br:article/983Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:10:40Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
El papel de las Proteínas Tempranas del Virus del Papiloma Humano en la Carcinogénesis
Papel das Proteínas Precoces do Papilomavírus Humano na Carcinogênese
title Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
spellingShingle Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
Pereira de Lima, Marcos Antonio
Humanos
Infecções por Papillomavirus
Papillomaviridae-classificação
Carcionógenos
Proteínas Oncogênicas Virais
Humans
Papillomavirus Infections
Papillomaviridae-classification
Carcinogens
Oncogene Proteins, Viral
Humanos
Infecciones por Papillomavirus
Papillomaviridae-classificacíon
Carcionógenos
Proteinas Oncogénicas Virales
title_short Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
title_full Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
title_fullStr Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
title_full_unstemmed Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
title_sort Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
author Pereira de Lima, Marcos Antonio
author_facet Pereira de Lima, Marcos Antonio
Gleidiston Lima da Silva, Cláudio
Barem Rabenhorst, Silvia Helena
author_role author
author2 Gleidiston Lima da Silva, Cláudio
Barem Rabenhorst, Silvia Helena
author2_role author
author
dc.contributor.author.fl_str_mv Pereira de Lima, Marcos Antonio
Gleidiston Lima da Silva, Cláudio
Barem Rabenhorst, Silvia Helena
dc.subject.por.fl_str_mv Humanos
Infecções por Papillomavirus
Papillomaviridae-classificação
Carcionógenos
Proteínas Oncogênicas Virais
Humans
Papillomavirus Infections
Papillomaviridae-classification
Carcinogens
Oncogene Proteins, Viral
Humanos
Infecciones por Papillomavirus
Papillomaviridae-classificacíon
Carcionógenos
Proteinas Oncogénicas Virales
topic Humanos
Infecções por Papillomavirus
Papillomaviridae-classificação
Carcionógenos
Proteínas Oncogênicas Virais
Humans
Papillomavirus Infections
Papillomaviridae-classification
Carcinogens
Oncogene Proteins, Viral
Humanos
Infecciones por Papillomavirus
Papillomaviridae-classificacíon
Carcionógenos
Proteinas Oncogénicas Virales
description Introduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/983
10.32635/2176-9745.RBC.2013v59n4.983
url https://rbc.inca.gov.br/index.php/revista/article/view/983
identifier_str_mv 10.32635/2176-9745.RBC.2013v59n4.983
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/983/592
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 59 No. 4 (2013): Oct./Nov./Dec.; 565-573
Revista Brasileira de Cancerologia; Vol. 59 Núm. 4 (2013): oct./nov./dic.; 565-573
Revista Brasileira de Cancerologia; v. 59 n. 4 (2013): out./nov./dez.; 565-573
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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