Role of the Human Papillomavirus Early Proteins in the Carcinogenesis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/983 |
Resumo: | Introduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance. |
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Role of the Human Papillomavirus Early Proteins in the CarcinogenesisEl papel de las Proteínas Tempranas del Virus del Papiloma Humano en la CarcinogénesisPapel das Proteínas Precoces do Papilomavírus Humano na CarcinogêneseHumanosInfecções por PapillomavirusPapillomaviridae-classificaçãoCarcionógenosProteínas Oncogênicas ViraisHumansPapillomavirus InfectionsPapillomaviridae-classificationCarcinogensOncogene Proteins, ViralHumanosInfecciones por PapillomavirusPapillomaviridae-classificacíonCarcionógenosProteinas Oncogénicas ViralesIntroduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance.Introducción: El Virus del Papiloma Humano (VPH) es un agente epiteliotropico que tiene mas de 100 genotipos. Entre ellos, algunos estan considerados de alto riesgo debido al potencial para inducir al desarrollo de lesiones malignas, tales como el carcinoma de cuello uterino, cuyo porcentaje de asociacion con el mencionado virus representa casi el 90%. En las celulas infectadas, dos proteinas virales desarrollan un papel importante en la tumorigenesis. Objetivo: Realizar una revision de los estudios existentes en la literatura cientifica internacional centrandose en el papel de las proteinas virales del VPH en la carcinogenesis. Método: Los articulos utilizados para la realizacion de esta revision fueron seleccionados y conseguidos en su version completa en los portales electronicos: Pubmed y Periodicos Capes. Las palabras claves utilizadas en la busqueda fueron: Virus del Papiloma Humano, VPH, las proteinas virales, E5, E6 y E7. Resultados: Proteinas virales E6 y E7 son ampliamente conocidas porque promueven la degradacion de las proteinas celulares p53 y pRb, respectivamente, efecto que es responsable por la mayor parte del potencial oncogenico de los genotipos de alto riesgo de PVH, los cuales son funcionalmente equivalentes a las mutaciones de estos genes celulares, que se observan comunmente en muchos tumores. Sin embargo, otros estudios han demostrado que estas proteinas virales tambien estan implicadas en otras vias tumorales, lo que demuestra una vez mas su importancia en este proceso. Por otra parte, algunos estudios senalan a la proteina E5 como un adyuvante en la carcinogenesis. Conclusión: Los distintos efectos observados de las proteinas tempranas virales culminan en favor de la proliferacion incontrolada de celulas, la inmortalizacion, la regulacion de la diferenciacion celular, la susceptibilidad a la metastasis y el escape de la vigilancia inmunologica.Introdução: O Papilomavírus Humano (HPV) e um agente epiteliotrópico que apresenta mais de 100 genótipos. Destes, alguns são considerados de alto risco devido ao potencial para induzir o surgimento de lesões malignas, como o carcinoma cervical, cujo percentual de associação com o referido vírus e de aproximadamente 90%. Nas células infectadas, duas proteínas virais desempenham papel fundamental na tumorigênese. Objetivo: Realizar uma revisão dos trabalhos existentes na literatura cientifica internacional com enfoque no papel das proteínas virais do HPV na carcinogênese. Método: Os artigos utilizados para a realização da presente revisão foram selecionados e obtidos na integra nos portais eletrônicos PubMed e Periódicos Capes. Os descritores utilizados na busca incluíram: Human Papillomavirus, HPV, viral proteins, E5, E6 e E7. Resultados: As proteínas virais E6 e E7 são amplamente conhecidas por promoverem a degradação das proteínas celulares p53 e pRb, respectivamente, efeito que responde por grande parte do potencial ontogênico dos genótipos de alto risco de HPV, sendo funcionalmente equivalentes a mutações dos referidos genes celulares, que são comumente observadas em diversos tumores. Contudo, novos estudos tem demonstrado que essas proteínas virais também estão envolvidas em diversas outras vias tumorais, denotando novamente a relevância das mesmas nesse processo. Ademais, alguns trabalhos apontam a proteína E5 como coadjuvante na carcinogênese. Conclusão: Os diversos efeitos constatados das proteínas precoces virais culminam no favorecimento da proliferação celular descontrolada, imortalização, regulação da diferenciação celular, suscetibilidade a metástase e escape da vigilância imunológica.INCA2013-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/98310.32635/2176-9745.RBC.2013v59n4.983Revista Brasileira de Cancerologia; Vol. 59 No. 4 (2013): Oct./Nov./Dec.; 565-573Revista Brasileira de Cancerologia; Vol. 59 Núm. 4 (2013): oct./nov./dic.; 565-573Revista Brasileira de Cancerologia; v. 59 n. 4 (2013): out./nov./dez.; 565-5732176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/983/592Pereira de Lima, Marcos AntonioGleidiston Lima da Silva, CláudioBarem Rabenhorst, Silvia Helenainfo:eu-repo/semantics/openAccess2021-11-29T20:10:40Zoai:rbc.inca.gov.br:article/983Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:10:40Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis El papel de las Proteínas Tempranas del Virus del Papiloma Humano en la Carcinogénesis Papel das Proteínas Precoces do Papilomavírus Humano na Carcinogênese |
title |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
spellingShingle |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis Pereira de Lima, Marcos Antonio Humanos Infecções por Papillomavirus Papillomaviridae-classificação Carcionógenos Proteínas Oncogênicas Virais Humans Papillomavirus Infections Papillomaviridae-classification Carcinogens Oncogene Proteins, Viral Humanos Infecciones por Papillomavirus Papillomaviridae-classificacíon Carcionógenos Proteinas Oncogénicas Virales |
title_short |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
title_full |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
title_fullStr |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
title_full_unstemmed |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
title_sort |
Role of the Human Papillomavirus Early Proteins in the Carcinogenesis |
author |
Pereira de Lima, Marcos Antonio |
author_facet |
Pereira de Lima, Marcos Antonio Gleidiston Lima da Silva, Cláudio Barem Rabenhorst, Silvia Helena |
author_role |
author |
author2 |
Gleidiston Lima da Silva, Cláudio Barem Rabenhorst, Silvia Helena |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pereira de Lima, Marcos Antonio Gleidiston Lima da Silva, Cláudio Barem Rabenhorst, Silvia Helena |
dc.subject.por.fl_str_mv |
Humanos Infecções por Papillomavirus Papillomaviridae-classificação Carcionógenos Proteínas Oncogênicas Virais Humans Papillomavirus Infections Papillomaviridae-classification Carcinogens Oncogene Proteins, Viral Humanos Infecciones por Papillomavirus Papillomaviridae-classificacíon Carcionógenos Proteinas Oncogénicas Virales |
topic |
Humanos Infecções por Papillomavirus Papillomaviridae-classificação Carcionógenos Proteínas Oncogênicas Virais Humans Papillomavirus Infections Papillomaviridae-classification Carcinogens Oncogene Proteins, Viral Humanos Infecciones por Papillomavirus Papillomaviridae-classificacíon Carcionógenos Proteinas Oncogénicas Virales |
description |
Introduction: The Human Papillomavirus (HPV) is an epitheliotropic agent which has more than 100 genotypes. Among these, some are considered high-risk due to the potential to induce the onset of malignant lesions, such as cervical carcinoma whose percentage of association with the HPV is around 90%. In the infected cells, two viral proteins play important role in tumorigenesis. Objective: A review of papers found in the worldwide scientific literature focusing on the role of HPV viral proteins in carcinogenesis. Method: The articles used in the present review were selected and obtained in full from the electronic portals “Pubmed” and “Portal de periodicos da Capes”. The key-words used in the search included: Human Papillomavirus, HPV, viral proteins, E5, E6 and E7. Results: The E6 and E7 viral proteins are widely known for promoting degradation of the p53 and pRb cellular proteins, respectively, effect which accounts for the much of the oncogenic potential of the high-risk genotype of HPV, being functionally equivalent to mutations of the mentioned cellular genes, which are commonly observed in several tumors. However, new studies have demonstrated that these proteins are also involved in many other tumor pathways, denoting again their relevance in this process. In addition, some studies have pointed the E5 as an adjuvant in carcinogenesis. Conclusion: The diverse effects related to early proteins culminate in the promotion of uncontrolled cell proliferation, immortalization, regulation of the cell differentiation, susceptibility to metastasis and escape from the immune surveillance. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/983 10.32635/2176-9745.RBC.2013v59n4.983 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/983 |
identifier_str_mv |
10.32635/2176-9745.RBC.2013v59n4.983 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/983/592 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 59 No. 4 (2013): Oct./Nov./Dec.; 565-573 Revista Brasileira de Cancerologia; Vol. 59 Núm. 4 (2013): oct./nov./dic.; 565-573 Revista Brasileira de Cancerologia; v. 59 n. 4 (2013): out./nov./dez.; 565-573 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042246024953856 |