Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents

Detalhes bibliográficos
Autor(a) principal: Meireles, José Roberto Cardoso
Data de Publicação: 2006
Outros Autores: Lopes, Maíza Alves, Alves, Nora Ney, Cerqueira, Eneida de Moraes Marcílio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1848
Resumo: Alterations indicative of apoptosis are potential genetic markers in the prevention of cancer, since they point to genotoxic effects. In this study, the frequencies of apoptotic alterations (pyknosis, condensed chromatin, and karyorrhexis) in exfoliated cells of the oral mucosa were evaluated in two groups of 30 individuals each. The exposed group consisted of individuals who handled chemical substances in university biology, chemistry, and pharmacology research laboratories, and the control group included people with no history of occupational exposure to these substances. Nuclear alterations indicative of apoptosis were significantly more frequent in the exposed group (p< 0.0001). The result shows the genotoxic effect of chemical substances used in these areas of laboratory research and highlights the health risks for individuals with such occupational exposure. Although the majority of individuals in the exposed group reported using personal or collective protective equipment, the high frequency of apoptosis in the exposed group shows the need for programs to prevent occupational exposure in university laboratories, as well as for workplace supervision in such research facilities.
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spelling Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agentsApoptose em células esfoliadas da mucosa bucal de indivíduos ocupacionalmente expostos a agentes mutagênicos e carcinogênicosApoptoseExposição ocupacionalGenotoxicidadeNeoplasiasApoptosisOccupational exposureGenotoxicityCancerAlterations indicative of apoptosis are potential genetic markers in the prevention of cancer, since they point to genotoxic effects. In this study, the frequencies of apoptotic alterations (pyknosis, condensed chromatin, and karyorrhexis) in exfoliated cells of the oral mucosa were evaluated in two groups of 30 individuals each. The exposed group consisted of individuals who handled chemical substances in university biology, chemistry, and pharmacology research laboratories, and the control group included people with no history of occupational exposure to these substances. Nuclear alterations indicative of apoptosis were significantly more frequent in the exposed group (p< 0.0001). The result shows the genotoxic effect of chemical substances used in these areas of laboratory research and highlights the health risks for individuals with such occupational exposure. Although the majority of individuals in the exposed group reported using personal or collective protective equipment, the high frequency of apoptosis in the exposed group shows the need for programs to prevent occupational exposure in university laboratories, as well as for workplace supervision in such research facilities.As alterações indicativas de apoptose são potenciais marcadores genéticos na prevenção do câncer, uma vez que apontam efeitos genotóxicos. Neste estudo, foram avaliadas as freqüências de alterações indicativas de apoptose (picnose, cromatina condensada e cariorréxis) em células esfoliadas da mucosa oral de trinta indivíduos que lidam com substâncias químicas em laboratórios acadêmicos de pesquisa das áreas de Ciências Biológicas, Químicas e Farmacêuticas (grupo exposto-GE), comparando-as às obtidas em igual número de indivíduos sem história de exposição ocupacional a mutágenos (grupo controle-GC). As alterações nucleares degenerativas indicativas de apoptose foram significativamente mais freqüentes no GE (p< 0,0001). Esse resultado evidencia o efeito genotóxico de compostos químicos utilizados na pesquisa acadêmica e aponta para riscos à saúde dos indivíduos que estão sob este tipo de exposição ocupacional. Embora a maioria dos entrevistados tenha declarado uso de equipamento para proteção individual e/ou coletiva, a elevada freqüência de apoptose observada no grupo exposto revela a necessidade de implantação de programas de prevenção à exposição ocupacional nas universidades e supervisão do ambiente de trabalho dos seus laboratórios de pesquisa nas áreas amostradas nesse estudo.INCA2006-12-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/184810.32635/2176-9745.RBC.2006v52n4.1848Revista Brasileira de Cancerologia; Vol. 52 No. 4 (2006): Oct.Nov./Dec.; 337-343Revista Brasileira de Cancerologia; Vol. 52 Núm. 4 (2006): oct./nov./dic.; 337-343Revista Brasileira de Cancerologia; v. 52 n. 4 (2006): out./nov./dez.; 337-3432176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1848/1122Meireles, José Roberto Cardoso Lopes, Maíza Alves Alves, Nora Ney Cerqueira, Eneida de Moraes Marcílio info:eu-repo/semantics/openAccess2021-11-29T20:27:25Zoai:rbc.inca.gov.br:article/1848Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:27:25Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
Apoptose em células esfoliadas da mucosa bucal de indivíduos ocupacionalmente expostos a agentes mutagênicos e carcinogênicos
title Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
spellingShingle Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
Meireles, José Roberto Cardoso
Apoptose
Exposição ocupacional
Genotoxicidade
Neoplasias
Apoptosis
Occupational exposure
Genotoxicity
Cancer
title_short Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
title_full Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
title_fullStr Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
title_full_unstemmed Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
title_sort Apoptosis in exfoliated cells from the oral mucosa of individuals occupationally exposed to mutagenic and carcinogenic agents
author Meireles, José Roberto Cardoso
author_facet Meireles, José Roberto Cardoso
Lopes, Maíza Alves
Alves, Nora Ney
Cerqueira, Eneida de Moraes Marcílio
author_role author
author2 Lopes, Maíza Alves
Alves, Nora Ney
Cerqueira, Eneida de Moraes Marcílio
author2_role author
author
author
dc.contributor.author.fl_str_mv Meireles, José Roberto Cardoso
Lopes, Maíza Alves
Alves, Nora Ney
Cerqueira, Eneida de Moraes Marcílio
dc.subject.por.fl_str_mv Apoptose
Exposição ocupacional
Genotoxicidade
Neoplasias
Apoptosis
Occupational exposure
Genotoxicity
Cancer
topic Apoptose
Exposição ocupacional
Genotoxicidade
Neoplasias
Apoptosis
Occupational exposure
Genotoxicity
Cancer
description Alterations indicative of apoptosis are potential genetic markers in the prevention of cancer, since they point to genotoxic effects. In this study, the frequencies of apoptotic alterations (pyknosis, condensed chromatin, and karyorrhexis) in exfoliated cells of the oral mucosa were evaluated in two groups of 30 individuals each. The exposed group consisted of individuals who handled chemical substances in university biology, chemistry, and pharmacology research laboratories, and the control group included people with no history of occupational exposure to these substances. Nuclear alterations indicative of apoptosis were significantly more frequent in the exposed group (p< 0.0001). The result shows the genotoxic effect of chemical substances used in these areas of laboratory research and highlights the health risks for individuals with such occupational exposure. Although the majority of individuals in the exposed group reported using personal or collective protective equipment, the high frequency of apoptosis in the exposed group shows the need for programs to prevent occupational exposure in university laboratories, as well as for workplace supervision in such research facilities.
publishDate 2006
dc.date.none.fl_str_mv 2006-12-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1848
10.32635/2176-9745.RBC.2006v52n4.1848
url https://rbc.inca.gov.br/index.php/revista/article/view/1848
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n4.1848
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1848/1122
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 4 (2006): Oct.Nov./Dec.; 337-343
Revista Brasileira de Cancerologia; Vol. 52 Núm. 4 (2006): oct./nov./dic.; 337-343
Revista Brasileira de Cancerologia; v. 52 n. 4 (2006): out./nov./dez.; 337-343
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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