Antileukemic Activity of Natural Killer (NK) Cells

Detalhes bibliográficos
Autor(a) principal: Oliveira, Aline Almeida
Data de Publicação: 2008
Outros Autores: Diamond, Hilda Rachel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1728
Resumo: Since the 1970s, natural killer (NK) cells have been known for their ability to kill virus-infected and tumor cells without prior sensitization. Because of their antileukemic potential, NK cells held great promise for clinical application. However, the initial results fell short of expectations. More recently, important progress has been made in NK cell biology, mainly in the field of target cell recognition through a unique repertoire of receptors. These advances have impacted the study of the antileukemic role of NK cells. Modern concepts, together with methodological progress, have shed new light on NK cell immunotherapy, which now is closer to clinical practice. This review discusses some of these new concepts, emphasizing mechanisms of target cell recognition in the antileukemic role. It also discusses recent advances in NK cell immunotherapy and difficulties for the clinical application of this therapy.
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spelling Antileukemic Activity of Natural Killer (NK) CellsAtividade Antileucêmica das Células Natural Killer (NK)Células matadoras naturaisImunoterapiaLeucemiaKiller cells, naturalImmunotherapyLeukemiaSince the 1970s, natural killer (NK) cells have been known for their ability to kill virus-infected and tumor cells without prior sensitization. Because of their antileukemic potential, NK cells held great promise for clinical application. However, the initial results fell short of expectations. More recently, important progress has been made in NK cell biology, mainly in the field of target cell recognition through a unique repertoire of receptors. These advances have impacted the study of the antileukemic role of NK cells. Modern concepts, together with methodological progress, have shed new light on NK cell immunotherapy, which now is closer to clinical practice. This review discusses some of these new concepts, emphasizing mechanisms of target cell recognition in the antileukemic role. It also discusses recent advances in NK cell immunotherapy and difficulties for the clinical application of this therapy.As células natural killer (NK) são conhecidas desde a década de 1970 por sua capacidade de matar células tumorais e infectadas por vírus sem sensibilização prévia. Além disso, essas células têm conhecido papel antileucêmico, o que levou à possibilidade de uma aplicação clínica das células NK. No entanto os resultados iniciais não foram promissores. Recentemente, houve um grande progresso no entendimento da biologia das células NK, principalmente nos mecanismos de reconhecimento das células-alvo através de um repertório próprio de receptores. Esses avanços causaram impacto no estudo do papel antileucêmico das células NK. Os conceitos modernos, junto com progressos metodológicos, impulsionaram o estudo da imunoterapia com células NK, que hoje se encontra mais próxima da prática clínica. Nesta revisão, serão abordados alguns desses novos conceitos, enfatizando os mecanismos de reconhecimento da célula alvo no papel antileucêmico. Também serão discutidos os avanços recentes da imunoterapia com células NK e as dificuldades de sua aplicação na prática clínica.INCA2008-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/172810.32635/2176-9745.RBC.2008v54n3.1728Revista Brasileira de Cancerologia; Vol. 54 No. 3 (2008): July/Aug./Sept.; 297-305Revista Brasileira de Cancerologia; Vol. 54 Núm. 3 (2008): jul./ago./sept.; 297-305Revista Brasileira de Cancerologia; v. 54 n. 3 (2008): jul./ago./set.; 297-3052176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1728/1022Oliveira, Aline Almeida Diamond, Hilda Rachel info:eu-repo/semantics/openAccess2021-11-29T20:22:32Zoai:rbc.inca.gov.br:article/1728Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:22:32Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Antileukemic Activity of Natural Killer (NK) Cells
Atividade Antileucêmica das Células Natural Killer (NK)
title Antileukemic Activity of Natural Killer (NK) Cells
spellingShingle Antileukemic Activity of Natural Killer (NK) Cells
Oliveira, Aline Almeida
Células matadoras naturais
Imunoterapia
Leucemia
Killer cells, natural
Immunotherapy
Leukemia
title_short Antileukemic Activity of Natural Killer (NK) Cells
title_full Antileukemic Activity of Natural Killer (NK) Cells
title_fullStr Antileukemic Activity of Natural Killer (NK) Cells
title_full_unstemmed Antileukemic Activity of Natural Killer (NK) Cells
title_sort Antileukemic Activity of Natural Killer (NK) Cells
author Oliveira, Aline Almeida
author_facet Oliveira, Aline Almeida
Diamond, Hilda Rachel
author_role author
author2 Diamond, Hilda Rachel
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Aline Almeida
Diamond, Hilda Rachel
dc.subject.por.fl_str_mv Células matadoras naturais
Imunoterapia
Leucemia
Killer cells, natural
Immunotherapy
Leukemia
topic Células matadoras naturais
Imunoterapia
Leucemia
Killer cells, natural
Immunotherapy
Leukemia
description Since the 1970s, natural killer (NK) cells have been known for their ability to kill virus-infected and tumor cells without prior sensitization. Because of their antileukemic potential, NK cells held great promise for clinical application. However, the initial results fell short of expectations. More recently, important progress has been made in NK cell biology, mainly in the field of target cell recognition through a unique repertoire of receptors. These advances have impacted the study of the antileukemic role of NK cells. Modern concepts, together with methodological progress, have shed new light on NK cell immunotherapy, which now is closer to clinical practice. This review discusses some of these new concepts, emphasizing mechanisms of target cell recognition in the antileukemic role. It also discusses recent advances in NK cell immunotherapy and difficulties for the clinical application of this therapy.
publishDate 2008
dc.date.none.fl_str_mv 2008-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1728
10.32635/2176-9745.RBC.2008v54n3.1728
url https://rbc.inca.gov.br/index.php/revista/article/view/1728
identifier_str_mv 10.32635/2176-9745.RBC.2008v54n3.1728
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1728/1022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 54 No. 3 (2008): July/Aug./Sept.; 297-305
Revista Brasileira de Cancerologia; Vol. 54 Núm. 3 (2008): jul./ago./sept.; 297-305
Revista Brasileira de Cancerologia; v. 54 n. 3 (2008): jul./ago./set.; 297-305
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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