"Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept

Detalhes bibliográficos
Autor(a) principal: Valadão, Marcus
Data de Publicação: 2009
Outros Autores: Linhares, Eduardo, Vilhena, Bruno, Guimarães, Denise, Ferreira, Carlos Gil
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1616
Resumo: Recent progress in gastrointestinal stromal tumor's (GIST) treatment was responsible for changing GIST's natural history. Knowlegde acquirement on molecular mechanism-based systemic therapy gave rise to the development of targeted antineoplastic drugs capable of reaching outcomes that had never been reached before. The introduction of imatinib in the clinical practice not only changed GIST patients´ survival, but also shifted paradigms. However, although imatinib has been considered the standard treatment of metastatic GIST, surgeon's role in this setting is being investigated. There is some evidence that surgery after imatinib treatment would benefit selected patients with metastatic disease. Therefore, a new concept has developed: "adjuvant surgery" as a new strategy to optimize treatment outcome in GIST metastatic scenario.
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spelling "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept"Cirugía Adyuvante" en el Tratamiento del Tumor Estromal Gastrointestinal Metastásico: un Nuevo Concepto"Cirurgia Adjuvante" no Tratamento do Tumor Estromal Gastrointestinal Metastático: um Novo ConceitoNeoplasias GastrointestinaisTumores do Estroma GastrointestinalCirurgia/TendênciasBiologia MolecularRevisãoGastrointestinal NeoplasmsGastrointestinal Stromal TumorsSurgery /TrendsMolecular BiologyReviewNeoplasias GastrointestinalesTumores del Estroma GastrointestinalCirugía /TendenciasBiología MolecularRevisiónRecent progress in gastrointestinal stromal tumor's (GIST) treatment was responsible for changing GIST's natural history. Knowlegde acquirement on molecular mechanism-based systemic therapy gave rise to the development of targeted antineoplastic drugs capable of reaching outcomes that had never been reached before. The introduction of imatinib in the clinical practice not only changed GIST patients´ survival, but also shifted paradigms. However, although imatinib has been considered the standard treatment of metastatic GIST, surgeon's role in this setting is being investigated. There is some evidence that surgery after imatinib treatment would benefit selected patients with metastatic disease. Therefore, a new concept has developed: "adjuvant surgery" as a new strategy to optimize treatment outcome in GIST metastatic scenario.Los recientes avances en el tratamiento de tumores estromales gastrointestinales (GIST) fueron responsables de cambiar la historia natural de la enfermedad. El mejor conocimiento de los mecanismos moleculares ha sido fundamental para el desarrollo de la terapia molecular dirigida, capaz de obtener resultados hasta entonces jamás logrados en ningún tratamiento de tumor sólido. La introducción del imatinib en la práctica clínica ha cambiado no sólo la supervivencia de los pacientes con GIST metastásico, sino también fue responsable de la quiebra de paradigmas bien establecidos, pero, a pesar del tratamiento de la enfermedad metastásica estar basada en la utilización del imatinib, el papel del cirujano, en este contexto, ha sido revisado, habiendo algunos indicios de que la cirugía de rescate en la enfermedad metastásica puede traer beneficios a grupos seleccionados de pacientes. Por lo tanto, un nuevo concepto se ha establecido, el de la "cirugía adyuvante", es decir, una estrategia terapéutica que apunta a optimizar los resultados del tratamiento del GIST metastásico.Os recentes avanços no tratamento dos tumores estromais gastrointestinais (GIST) foram responsáveis pela mudança da história natural da doença. O melhor conhecimento dos mecanismos moleculares foi fundamental para o desenvolvimento de droga alvo-molecular dirigida capaz de obter resultados, até então, não alcançados em nenhum tratamento de tumor sólido. A introdução do imatinibe na prática clínica modificou não só a sobrevida dos portadores de GIST metastático, como também foi responsável por quebras de paradigmas bem estabelecidos; porém, apesar de o tratamento da doença metastática ser baseado na utilização do imatinibe, o papel do cirurgião, nesse contexto, tem sido revisado, havendo alguns indícios de que a cirurgia de resgate na doença metastática possa trazer benefícios a grupos selecionados de pacientes. Dessa forma, um novo conceito se estabelece, o da "cirurgia adjuvante"; ou seja, uma estratégia terapêutica que visa a otimizar os resultados do tratamento do GIST metastático.INCA2009-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo de opniãoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/161610.32635/2176-9745.RBC.2009v55n3.1616Revista Brasileira de Cancerologia; Vol. 55 No. 3 (2009): July/Aug./Sept.; 297-301Revista Brasileira de Cancerologia; Vol. 55 Núm. 3 (2009): jul./ago./sept.; 297-301Revista Brasileira de Cancerologia; v. 55 n. 3 (2009): jul./ago./set.; 297-3012176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1616/960Valadão, MarcusLinhares, EduardoVilhena, BrunoGuimarães, DeniseFerreira, Carlos Gilinfo:eu-repo/semantics/openAccess2021-11-29T20:20:33Zoai:rbc.inca.gov.br:article/1616Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:20:33Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
"Cirugía Adyuvante" en el Tratamiento del Tumor Estromal Gastrointestinal Metastásico: un Nuevo Concepto
"Cirurgia Adjuvante" no Tratamento do Tumor Estromal Gastrointestinal Metastático: um Novo Conceito
title "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
spellingShingle "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
Valadão, Marcus
Neoplasias Gastrointestinais
Tumores do Estroma Gastrointestinal
Cirurgia/Tendências
Biologia Molecular
Revisão
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Surgery /Trends
Molecular Biology
Review
Neoplasias Gastrointestinales
Tumores del Estroma Gastrointestinal
Cirugía /Tendencias
Biología Molecular
Revisión
title_short "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
title_full "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
title_fullStr "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
title_full_unstemmed "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
title_sort "Adjuvant Surgery" in the Treatment of Metastatic Gastrointestinal Stromal Tumor's: a New Concept
author Valadão, Marcus
author_facet Valadão, Marcus
Linhares, Eduardo
Vilhena, Bruno
Guimarães, Denise
Ferreira, Carlos Gil
author_role author
author2 Linhares, Eduardo
Vilhena, Bruno
Guimarães, Denise
Ferreira, Carlos Gil
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Valadão, Marcus
Linhares, Eduardo
Vilhena, Bruno
Guimarães, Denise
Ferreira, Carlos Gil
dc.subject.por.fl_str_mv Neoplasias Gastrointestinais
Tumores do Estroma Gastrointestinal
Cirurgia/Tendências
Biologia Molecular
Revisão
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Surgery /Trends
Molecular Biology
Review
Neoplasias Gastrointestinales
Tumores del Estroma Gastrointestinal
Cirugía /Tendencias
Biología Molecular
Revisión
topic Neoplasias Gastrointestinais
Tumores do Estroma Gastrointestinal
Cirurgia/Tendências
Biologia Molecular
Revisão
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Surgery /Trends
Molecular Biology
Review
Neoplasias Gastrointestinales
Tumores del Estroma Gastrointestinal
Cirugía /Tendencias
Biología Molecular
Revisión
description Recent progress in gastrointestinal stromal tumor's (GIST) treatment was responsible for changing GIST's natural history. Knowlegde acquirement on molecular mechanism-based systemic therapy gave rise to the development of targeted antineoplastic drugs capable of reaching outcomes that had never been reached before. The introduction of imatinib in the clinical practice not only changed GIST patients´ survival, but also shifted paradigms. However, although imatinib has been considered the standard treatment of metastatic GIST, surgeon's role in this setting is being investigated. There is some evidence that surgery after imatinib treatment would benefit selected patients with metastatic disease. Therefore, a new concept has developed: "adjuvant surgery" as a new strategy to optimize treatment outcome in GIST metastatic scenario.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo de opnião
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1616
10.32635/2176-9745.RBC.2009v55n3.1616
url https://rbc.inca.gov.br/index.php/revista/article/view/1616
identifier_str_mv 10.32635/2176-9745.RBC.2009v55n3.1616
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1616/960
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 55 No. 3 (2009): July/Aug./Sept.; 297-301
Revista Brasileira de Cancerologia; Vol. 55 Núm. 3 (2009): jul./ago./sept.; 297-301
Revista Brasileira de Cancerologia; v. 55 n. 3 (2009): jul./ago./set.; 297-301
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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