Alcohol and Oral Cancer: Comments on Related Mechanisms

Detalhes bibliográficos
Autor(a) principal: Carrard, Vinícius Coelho
Data de Publicação: 2008
Outros Autores: Pires, Aline Segatto, Paiva, Ricardo Losekann, Chaves, Anna Cecília Moraes, Sant'Ana Filho, Manoel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1760
Resumo: Alcohol consumption is a risk factor for the development of oral cancer, but the mechanisms involved in the damage caused by alcohol consumption are only partially understood. Certain alcohol levels cause an increase in the permeability of the oral mucosa, facilitating the penetration of carcinogens. Alcohol also increases epithelial proliferation and modifies the epithelial maturation process. Other alterations such as reduced capacity for DNA repair and disorders of the immune system and nutritional status can contribute to the development of oral cancer. Alcohol metabolism increases the production of free radicals and decreases anti-oxidative mechanisms, leading to oxidative stress. Gene polymorphism in the genes involved in alcohol catabolism may account for the difference in individual sensitivity. Some isoforms of these enzymes allow the accumulation of toxic metabolites like acetaldehyde, which damage DNA and other cell structures. Based on a literature review, the current article aims to establish a relationship between the various mechanisms involved in the effect of alcohol and carcinogenesis in the oral cavity.
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spelling Alcohol and Oral Cancer: Comments on Related MechanismsÁlcool e Câncer Bucal: Considerações sobre os Mecanismos RelacionadosEtanolCarcinoma de células escamosasMucosa bucalEthanolSquamous cell carcinomaOral mucosaAlcohol consumption is a risk factor for the development of oral cancer, but the mechanisms involved in the damage caused by alcohol consumption are only partially understood. Certain alcohol levels cause an increase in the permeability of the oral mucosa, facilitating the penetration of carcinogens. Alcohol also increases epithelial proliferation and modifies the epithelial maturation process. Other alterations such as reduced capacity for DNA repair and disorders of the immune system and nutritional status can contribute to the development of oral cancer. Alcohol metabolism increases the production of free radicals and decreases anti-oxidative mechanisms, leading to oxidative stress. Gene polymorphism in the genes involved in alcohol catabolism may account for the difference in individual sensitivity. Some isoforms of these enzymes allow the accumulation of toxic metabolites like acetaldehyde, which damage DNA and other cell structures. Based on a literature review, the current article aims to establish a relationship between the various mechanisms involved in the effect of alcohol and carcinogenesis in the oral cavity.O consumo de álcool é um dos fatores de risco para o desenvolvimento do câncer bucal; entretanto, os mecanismos envolvidos no dano gerado pelo álcool são parcialmente compreendidos. Determinadas concentrações de álcool causam aumento da permeabilidade da mucosa bucal, potencializando a penetração de carcinógenos. Além disso, é responsável por um aumento na proliferação epitelial, bem como pela modificação do seu processo de maturação. Outras alterações, como redução da capacidade de reparo de DNA, distúrbios do sistema imune e do estado nutricional podem contribuir na sua relação com o desenvolvimento do câncer bucal. O metabolismo do álcool aumenta a produção de radicais livres e diminui os mecanismos antioxidantes, levando ao estresse oxidativo. O polimorfismo genético das enzimas de degradação do álcool pode ser responsável pela diferença na sensibilidade individual. Algumas isoformas dessas enzimas permitem o acúmulo de metabólitos tóxicos como o acetadeído, que pode causar dano ao DNA ou a outras estruturas celulares. A partir de uma revisão de literatura, esse trabalho tem como objetivo estabelecer uma relação entre os diferentes mecanismos da ação do álcool e a carcinogênese na cavidade oral.INCA2008-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/176010.32635/2176-9745.RBC.2008v54n1.1760Revista Brasileira de Cancerologia; Vol. 54 No. 1 (2008): Jan./Feb./Mar.; 49-56Revista Brasileira de Cancerologia; Vol. 54 Núm. 1 (2008): ene./feb./mar.; 49-56Revista Brasileira de Cancerologia; v. 54 n. 1 (2008): jan./fev./mar.; 49-562176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1760/1048Carrard, Vinícius Coelho Pires, Aline Segatto Paiva, Ricardo Losekann Chaves, Anna Cecília Moraes Sant'Ana Filho, Manoel info:eu-repo/semantics/openAccess2021-11-29T20:24:04Zoai:rbc.inca.gov.br:article/1760Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:24:04Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Alcohol and Oral Cancer: Comments on Related Mechanisms
Álcool e Câncer Bucal: Considerações sobre os Mecanismos Relacionados
title Alcohol and Oral Cancer: Comments on Related Mechanisms
spellingShingle Alcohol and Oral Cancer: Comments on Related Mechanisms
Carrard, Vinícius Coelho
Etanol
Carcinoma de células escamosas
Mucosa bucal
Ethanol
Squamous cell carcinoma
Oral mucosa
title_short Alcohol and Oral Cancer: Comments on Related Mechanisms
title_full Alcohol and Oral Cancer: Comments on Related Mechanisms
title_fullStr Alcohol and Oral Cancer: Comments on Related Mechanisms
title_full_unstemmed Alcohol and Oral Cancer: Comments on Related Mechanisms
title_sort Alcohol and Oral Cancer: Comments on Related Mechanisms
author Carrard, Vinícius Coelho
author_facet Carrard, Vinícius Coelho
Pires, Aline Segatto
Paiva, Ricardo Losekann
Chaves, Anna Cecília Moraes
Sant'Ana Filho, Manoel
author_role author
author2 Pires, Aline Segatto
Paiva, Ricardo Losekann
Chaves, Anna Cecília Moraes
Sant'Ana Filho, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carrard, Vinícius Coelho
Pires, Aline Segatto
Paiva, Ricardo Losekann
Chaves, Anna Cecília Moraes
Sant'Ana Filho, Manoel
dc.subject.por.fl_str_mv Etanol
Carcinoma de células escamosas
Mucosa bucal
Ethanol
Squamous cell carcinoma
Oral mucosa
topic Etanol
Carcinoma de células escamosas
Mucosa bucal
Ethanol
Squamous cell carcinoma
Oral mucosa
description Alcohol consumption is a risk factor for the development of oral cancer, but the mechanisms involved in the damage caused by alcohol consumption are only partially understood. Certain alcohol levels cause an increase in the permeability of the oral mucosa, facilitating the penetration of carcinogens. Alcohol also increases epithelial proliferation and modifies the epithelial maturation process. Other alterations such as reduced capacity for DNA repair and disorders of the immune system and nutritional status can contribute to the development of oral cancer. Alcohol metabolism increases the production of free radicals and decreases anti-oxidative mechanisms, leading to oxidative stress. Gene polymorphism in the genes involved in alcohol catabolism may account for the difference in individual sensitivity. Some isoforms of these enzymes allow the accumulation of toxic metabolites like acetaldehyde, which damage DNA and other cell structures. Based on a literature review, the current article aims to establish a relationship between the various mechanisms involved in the effect of alcohol and carcinogenesis in the oral cavity.
publishDate 2008
dc.date.none.fl_str_mv 2008-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1760
10.32635/2176-9745.RBC.2008v54n1.1760
url https://rbc.inca.gov.br/index.php/revista/article/view/1760
identifier_str_mv 10.32635/2176-9745.RBC.2008v54n1.1760
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1760/1048
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 54 No. 1 (2008): Jan./Feb./Mar.; 49-56
Revista Brasileira de Cancerologia; Vol. 54 Núm. 1 (2008): ene./feb./mar.; 49-56
Revista Brasileira de Cancerologia; v. 54 n. 1 (2008): jan./fev./mar.; 49-56
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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