BRCA Genes Contribution in the hereditary predisposition for breast cancer

Detalhes bibliográficos
Autor(a) principal: Amendola, Luis Cláudio Belo
Data de Publicação: 2005
Outros Autores: Vieira, Roberto
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1927
Resumo: Approximately 20% of the cases related to familiar breast cancer are associated to one gene of hereditary susceptibility for breast and ovarian cancer, BRCA1 and BRCA2. Recent works have demonstrated the mechanism of action of these genes, with functions well established for maintaining the genome integrity and for controlling homologates recombination. Familiar history, bilaterality, precocious diseases, as well as specific histopathologic results are indicative factors of the presence of mutation in these genes. This literature review summarizes some of this knowledge, trying to understand them in the current functional context of these genes.
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spelling BRCA Genes Contribution in the hereditary predisposition for breast cancerA contribuição dos genes BRCA na predisposição hereditária ao câncer de mamaNeoplasias mamáriasGenéticaGenes BRCABreast neoplasmsGeneticBRCA genesApproximately 20% of the cases related to familiar breast cancer are associated to one gene of hereditary susceptibility for breast and ovarian cancer, BRCA1 and BRCA2. Recent works have demonstrated the mechanism of action of these genes, with functions well established for maintaining the genome integrity and for controlling homologates recombination. Familiar history, bilaterality, precocious diseases, as well as specific histopathologic results are indicative factors of the presence of mutation in these genes. This literature review summarizes some of this knowledge, trying to understand them in the current functional context of these genes.Aproximadamente 20% dos casos de câncer de mama familiar estão associados a um dos genes de susceptibilidade hereditária para câncer de mama e ovário, BRCA1 e BRCA2. Recentes trabalhos têm demonstrado o mecanismo de ação destes genes com funções estabelecidas na manutenção da integridade do genoma e no controle da recombinação homóloga. A história familiar, a bilateralidade, o acometimento precoce e achados histopatológicos específicos são fatores sugestivos da presença de mutações nestes genes Esta revisão sumariza alguns destes conhecimentos, na tentativa de colocá-los no contexto atual das funções destes genes.INCA2005-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/192710.32635/2176-9745.RBC.2005v51n4.1927Revista Brasileira de Cancerologia; Vol. 51 No. 4 (2005): Oct./Nov./Dec.; 325-330Revista Brasileira de Cancerologia; Vol. 51 Núm. 4 (2005): oct./nov./dic.; 325-330Revista Brasileira de Cancerologia; v. 51 n. 4 (2005): out./nov./dez.; 325-3302176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1927/1171Amendola, Luis Cláudio BeloVieira, Robertoinfo:eu-repo/semantics/openAccess2021-11-29T20:29:16Zoai:rbc.inca.gov.br:article/1927Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:29:16Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv BRCA Genes Contribution in the hereditary predisposition for breast cancer
A contribuição dos genes BRCA na predisposição hereditária ao câncer de mama
title BRCA Genes Contribution in the hereditary predisposition for breast cancer
spellingShingle BRCA Genes Contribution in the hereditary predisposition for breast cancer
Amendola, Luis Cláudio Belo
Neoplasias mamárias
Genética
Genes BRCA
Breast neoplasms
Genetic
BRCA genes
title_short BRCA Genes Contribution in the hereditary predisposition for breast cancer
title_full BRCA Genes Contribution in the hereditary predisposition for breast cancer
title_fullStr BRCA Genes Contribution in the hereditary predisposition for breast cancer
title_full_unstemmed BRCA Genes Contribution in the hereditary predisposition for breast cancer
title_sort BRCA Genes Contribution in the hereditary predisposition for breast cancer
author Amendola, Luis Cláudio Belo
author_facet Amendola, Luis Cláudio Belo
Vieira, Roberto
author_role author
author2 Vieira, Roberto
author2_role author
dc.contributor.author.fl_str_mv Amendola, Luis Cláudio Belo
Vieira, Roberto
dc.subject.por.fl_str_mv Neoplasias mamárias
Genética
Genes BRCA
Breast neoplasms
Genetic
BRCA genes
topic Neoplasias mamárias
Genética
Genes BRCA
Breast neoplasms
Genetic
BRCA genes
description Approximately 20% of the cases related to familiar breast cancer are associated to one gene of hereditary susceptibility for breast and ovarian cancer, BRCA1 and BRCA2. Recent works have demonstrated the mechanism of action of these genes, with functions well established for maintaining the genome integrity and for controlling homologates recombination. Familiar history, bilaterality, precocious diseases, as well as specific histopathologic results are indicative factors of the presence of mutation in these genes. This literature review summarizes some of this knowledge, trying to understand them in the current functional context of these genes.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1927
10.32635/2176-9745.RBC.2005v51n4.1927
url https://rbc.inca.gov.br/index.php/revista/article/view/1927
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n4.1927
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1927/1171
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 4 (2005): Oct./Nov./Dec.; 325-330
Revista Brasileira de Cancerologia; Vol. 51 Núm. 4 (2005): oct./nov./dic.; 325-330
Revista Brasileira de Cancerologia; v. 51 n. 4 (2005): out./nov./dez.; 325-330
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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